MicroRNA 100: a context dependent miRNA in prostate cancer

Leite, Kátia R. M.; Morais, Denis R.; Reis, Sabrina T.; Viana, Nayara; Moura, Caio M.; Flórez, Manuel García; Silva, Iran A.; Dip, Nelson; Srougi, Miguel

doi:10.6061/clinics/2013(06)12

Cited by 36 publications

(30 citation statements)

References 12 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Deregulation of the miR-99 family contributes to tumorigenesis at least partially, by direct and indirect targeting at multiple points in mTOR signaling pathway. In some cancer types, including metastatic CRC [31] , esophageal squamous cell carcinoma (ESCC) [32, 33] , clear cell ovarian cancer [34] , cervical cancer [35] , breast cancer [36] ,prostate cancer [12, 37] , bladder cancer [38] , childhood adrenocortical tumor [39] , osteosarcoma [40] and c-Src-transformed cells [41] , miR-99 family members suppress mTOR expression via direct targeting of its 3′-UTR in a post-transcriptional manner. Ectopic overexpression of miR-99 family members in these cancers reduces cell proliferation and migration, induces apoptosis and enhance sensitivity to the rapamycin analog RAD001 (everolimus).…”

Section: Mirnas That Suppress Upstream Of Mtor Pathwaymentioning

confidence: 99%

“…Diverse upstream growth factors and cytokines enhance the PI3K/AKT/mTOR pathway, including IGF-1 [7] , VEGF [8] , c-Met [9] , and BDNF [10] . mTOR pathway is antagonized by negative regulators such as PTEN [11,12] , GSK3β [13] , LKB1/AMPK [14] , p53 [15] , DDIT4 [16] , PDCD4 [17] , and IKKβ [18] . Aberrant mTOR signaling pathway is known to be involved in many disease states particularly cancer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Emerging Role of MicroRNAs in mTOR Signaling

Zhang

Huang

Wang³

et al. 2017

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase that plays a critical role in the control of cellular growth and metabolism. Hyperactivation of mTOR pathway is common in human cancers, driving uncontrolled proliferation. MicroRNA (miRNA) is a class of short noncoding RNAs that regulate the expression of a wide variety of genes. Deregulation of miRNAs is a hallmark of cancer. Recent studies have revealed interplays between miRNAs and the mTOR pathway during cancer development. Such interactions appear to provide a fine-tuning of various cellular functions and contribute qualitatively to the behavior of cancer. Here we provide an overview of current knowledge regarding the reciprocal relationship between miRNAs and mTOR pathway: regulation of mTOR signaling by miRNAs and control of miRNA biogenesis by mTOR. Further research in this area may prove important for the diagnosis and therapy of human cancer.

show abstract

Section: Mirnas That Suppress Upstream Of Mtor Pathwaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emerging Role of MicroRNAs in mTOR Signaling

Zhang

Huang

Wang³

et al. 2017

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…Based on experimental results, they pointed out that miR-100 was a context-dependent miRNA in prostate cancer which influenced the fate of tumor cells. On the one hand, oncogenic miR-100 increases cell proliferation through the pRb pathway by down-regulating SMARCA5, BAZ2A and THAP2; on the other hand, miR-100 could also act as a tumor suppressor, cooperating with other factors to down-regulate the mTOR pathway [66]. So far, the molecular bases of these interactions and status of downstream targets of miR-100 have been studied by many scientists.…”

Section: Table 1 Dysregulation Of Mir-100 In Different Human Cancersmentioning

confidence: 99%

Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential

Li¹,

Gao²,

Zhang³

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are a recently discovered class of endogenous, small (about 22 nucleotides) non-coding RNAs, which play important roles in cancer development and progression. Emerging evidence shows that microRNAs exert their regulatory effects by directly binding to the 3'- untranslated regions (UTRs) of their target genes. MicroRNA-100 (miR-100) is aberrantly expressed and functions in many human cancers by regulating multiple cell processes, such as cell cycle, proliferation, differentiation, migration, invasion and apoptosis, via post-transcriptionally regulating various target genes. A better understanding of the molecular mechanisms involved in miR-100-mediated tumor progression will provide an opportunity for exploring novel miR-100-based targeted therapies for human cancers. This review aims to summarize the recently published literature on the roles of miR-100 in regulating tumorigenesis, and explore its potential clinical applications for cancer diagnosis, prognosis and clinical treatment.

show abstract

“…SMARCA5 is a member of the SWI/SNF protein family, which is involved in the cell cycle (Leite et al, 2013). It is required for DNA double-strand break repair and DNA replication (Yamaguchi et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Identification of differently expressed genes in leukemia using multiple microarray datasets

Zhang¹,

Xu²,

Guo³

et al. 2014

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The purpose of this study was to identify differentially expressed genes and analyze biological processes related to leukemia. A meta-analysis was performed using the Rank Product package of Gene Expression Omnibus datasets for leukemia. Next, Gene Ontology-enrichment analysis and pathway analysis were performed using the Gene Ontology website and Kyoto Encyclopedia of Genes and Genomes. A protein-protein interaction network was constructed using the Cytoscape software. Using the Rank Product package for leukemia, we identified a total of 1294 differentially expressed genes, 357 of which were not involved in individual differentially expressed genes. Gene Ontology-enrichment analyses showed that these 357 genes were enriched in biological processes such as mRNA metabolism, RNA splicing, and mRNA processing. Pathwayenrichment analysis showed that the genes were involved in the intestinal immune network for IgA production, endocytosis, and the mitogen-activated protein kinase signaling pathway. The proteinprotein interaction network indicated that HRAS, CD44, STAT1, SMAD2, and COPS5 were important in many interactions. Our study revealed genes that were consistently differentially expressed Differentially expressed genes in leukemia in leukemia, as well as the biological pathways and protein-protein interaction network associated with these genes.

show abstract

MicroRNA 100: a context dependent miRNA in prostate cancer

Cited by 36 publications

References 12 publications

Emerging Role of MicroRNAs in mTOR Signaling

Emerging Role of MicroRNAs in mTOR Signaling

Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential

Identification of differently expressed genes in leukemia using multiple microarray datasets

Contact Info

Product

Resources

About