Microribonucleic acid dysregulations in children and adolescents with obsessive–compulsive disorder

Abstract

AimObsessive–compulsive disorder (OCD) is a disorder characterized by the presence of obsessions and/or compulsions. Although disorder etiology and pathogenesis remains unknown, several theories about OCD development have been proposed, and many researchers believe that it is caused by both genetic and environmental factors. In the current study, our aim was to investigate miRNA levels in OCD.MethodsIn the current study, we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p, and miR155a-5p levels in child and adolescent OCD patients. The research sample consisted of a group of 23 OCD patients and 40 healthy volunteer controls.ResultsThere was no significant difference in age and sex between the two groups (P>0.05). The levels of miR22-3p, miR24-3p, miR106b-5p, miR125b-5p, and miR155a-5p were significantly increased in the OCD subjects (P≤0.05). There were no statistically significant differences in miR18a-5p or miR107 levels between groups (P≥0.05).ConclusionThere could be a close relationship between levels of circulating miRNAs and OCD. If we could understand how the signaling pathways arranged by miRNAs impact on central nervous system development, function, and pathology, this understanding could improve our knowledge about OCD etiology and treatment.

Harm avoidance and childhood adversities in patients with obsessive–compulsive disorder and their unaffected first‐degree relatives

“…The genetic overlap between harm avoidance and OCD, however, has not been investigated, yet, and should be addressed in future studies. With regard to epigenetics, patients with OCD show significant alterations in the expression of specific microRNAs compared to healthy controls and extensive differences in DNA methylation . As recent evidence from an epigenome‐wide study indicates that childhood trauma is associated with DNA methylation and cortisol stress reactivity , future research may explore whether the epigenetic alterations observed in OCD are mediated by adverse childhood experiences.…”

Systematic evaluation, verification and comparison of tuberculosis‐related non‐coding RNA diagnostic panels

“…Linear combination used in Cui 2017 took into account both the miRNA expression of each dataset itself and the weight of included variables, which might confer its excellent generalization ability. However, a miRNA extensively participates in various biological and physiological pathways and thus has potential to be a biomarker for several different diseases, such as miR769_5p, miR320a and miR22_3p in Cui 2017 41‐43 . Multiple roles of miRNAs in biological activities can decrease their specificity in a given disease.…”

“…Cui 2017 [41][42][43]. Multiple roles of miRNAs in biological activities can The performance of 13 miRNA models in all available miRNA datasets…”

Could neutrophil-to-lymphocyte ratio be an important parameter in children and adolescents with obsessive compulsive disorder? (eng)

“…Although the etiological processes of the pathophysiology of obsessive-compulsive disorder are not fully understood; neuroanatomic, neurochemical, genetic, environmental-personal, cognitive, behavioral and psychosocial factors have been suggested. The number of evidence for the role of inflammation in the etiology of early-onset obsessive-compulsive disorder has increased in recent years (2). There is evidence that inflammatory processes may play a direct role in the pathophysiology of some OCD subtypes, such as pediatric autoimmune neuropsychiatric diseases associated with streptococcal infection (PANDAS).…”