Harm avoidance and childhood adversities in patients with obsessive–compulsive disorder and their unaffected first‐degree relatives

Bey, Katharina; Lennertz, Leonhard; Riesel, Anja; Klawohn, Julia; Kaufmann, Christian; Heinzel, Stephan; Grützmann, Rosa; Kathmann, Norbert; Wagner, Michael

doi:10.1111/acps.12707

Cited by 33 publications

(28 citation statements)

References 80 publications

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“…Contrary to our hypothesis, we could not find any relationship between OCD symptom severity and CT severity/types of CT. Our finding is in line with previous clinical studies that found no significant relationship between CT and OCD severity [20][21][22]. In a meta-analysis suggesting that CTs are related to severity of compulsions but not the severity of obsessions, not only OCD but all Obsessive Compulsive Spectrum Disorders were included, which might explain the difference between our results and the results of the meta-analysis [23].…”

Section: Discussionsupporting

confidence: 90%

“…When we look at the relationship between CTs and OCD severity and chronicity, there are inconsistent results in the literature. Some studies found a significant relationship with CTs and OCD severity [17][18][19], while others did not [20][21][22]. In a recent meta-analysis, it has been found that exposure to trauma is related to the severity of compulsions, but not to the severity of obsessions [23].…”

Section: Introductionmentioning

confidence: 99%

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The effects of childhood emotional abuse on aggressive obsessions among patients with obsessive compulsive disorder may be mediated by symptoms of depression and anxiety

Kart

Türkçapar

2019

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: The purpose of this study was to evaluate the relationship between childhood traumas (CTs) and severity and symptom dimensions of Obsessive Compulsive Disorder (OCD). METHOD: One hundred and sixty (160) patients diagnosed with OCD were included. The Yale-Brown Obsessive-Compulsive Scale (YBOCS), the Childhood Trauma Questionnaire (CTQ), the Beck Depression Inventory (BDI), and the Beck Anxiety Inventory (BAI) were applied to the participants. RESULTS: According to a cutoff score of > 35 for CTQ total score, 71 (44.4%) OCD patients had no CT history and 89 (55.6%) OCD patients had CTs history. There were no significant difference between the two groups with regard to YBOCS total score or to obsessions and compulsions except aggressive obsessions. The associations between aggressive obsessions, BDI total score, BAI total score and emotional abuse were statistically significant, but the correlation between aggressive obsessions and emotional abuse was no longer significant after controlling for BDI and BAI total scores. In the parallel multiple mediator model analysis, there were not statistically significant mediator effects of depression and anxiety variables in the relationship between emotional abuse and aggressive obsessions. Mobility in childhood was significantly correlated with physical abuse, and this correlation was still significant after controlling for BDI and BAI total scores. BDI total score was significantly associated with sexual abuse. CONCLUSION: The relationship between CTs and OCD should be reconsidered in light of other contributing factors such as comorbidity.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The effects of childhood emotional abuse on aggressive obsessions among patients with obsessive compulsive disorder may be mediated by symptoms of depression and anxiety

Kart

Türkçapar

2019

Psychiatry and Clinical Psychopharmacology

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“…Third, impairment and treatment response were based on the participants' subjective ratings, and the adequacy of treatment trials and patients' compliance with recommended treatment were not known; further, the extent to which personality may have influenced perception and reporting of impairment and treatment response is unclear. Fourth, although we adjusted in analyses for several demographic and clinical features associated with personality, we cannot rule out potential confounding by other factors that might be associated with personality, impairment and treatment response in OCD, such as childhood adversities and adult traumatic experiences . Moreover, we did not assess dimensions of “state” anxiety and depression, which might impact impairment and treatment response, even in individuals without a history of anxiety and mood disorders.…”

Section: Discussionmentioning

confidence: 99%

General personality dimensions, impairment and treatment response in obsessive–compulsive disorder

Samuels

Bienvenu

Krasnow

et al. 2019

Personality & Mental Health

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General personality dimensions are associated with clinical severity and treatment response in individuals with depression and many anxiety disorders, but little is known about these relationships in individuals with obsessive-compulsive disorder (OCD). Individuals in the current study included 705 adults with OCD who had participated in family and genetic studies of the disorder. Participants self-completed the Neuroticism, Extraversion, Openness Personality Inventory or Neuroticism, Extraversion, Openness Five-Factor Inventory-3. Relationships between personality scores, and subjective impairment and OCD treatment response, were evaluated. The odds of subjective impairment increased with (unit increase in) the neuroticism score (odds ratio, OR = 1.03; 95% CI = 1.01-1.04; p < 0.01) and decreased with extraversion scores (OR = 0.98; 95% CI = 0.96-0.99; p < 0.01). The odds of reporting a good response to serotonin/selective serotonin reuptake inhibitors (OR = 1.02; 95% CI = 1.01-1.04; p < 0.01) or cognitive behavioural therapy (OR = 1.03; 95% CI = 1.01-1.05; p < 0.01) increased with the extraversion score. The magnitude of these relationships did not change appreciably after adjusting for other clinical features related to one or more of the personality dimensions. The findings suggest that neuroticism and extraversion are associated with subjective impairment, and that extraversion is associated with self-reported treatment response, in individuals with OCD.

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“…(48) Dados de uma meta-análise (49) Em resumo, dados da literatura supracitada, por meio de metodologias diversas, demonstram que parece haver uma relação entre experiências adversas na infância e adolescência e a presença de SOC e/ou TOC. Este último apareceu associado ao abuso sexual e negligência emocional (51) , a negligência e ao abuso emocional (62) . A presença de SOCs apareceu associada ao abuso emocional e à negligência física (59) ao abuso físico, à negligência (61) e ao abuso sexual (54,57,60).…”

Section: Resiliênciaunclassified

“…No estudo que envolveu familiares, foi encontrado que os pacientes tinham mais eventos adversos que seus parentes e controles (62) .…”

Section: Dados Clínicosunclassified

Experiências adversas na infância e adolescência, mediadores e transtorno obsessivo-compulsivo: um estudo com pacientes, irmãos e controles

Costa¹

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Versão corrigida. Resolução CoPGr 6018/11, de 13 de outubro de 2011. A versão original está disponível na Biblioteca da FMUSP) São Paulo 2018 Agradecimentos O presente trabalho não seria possível sem o precioso apoio de várias pessoas. Em primeiro lugar, agradeço ao meu orientador, Dr. Marcelo Queiroz Hoexter, pelo acolhimento e por ter aceitado desenvolver esse projeto. Agradeço, ainda, pela paciência, empenho e zelo com que sempre me orientou, de maneira próxima e cuidadosa durante todas as fases desse trabalho. Excelente interlocutor, com quem pude aprender e amadurecer. Obrigada pela confiança, pelo suporte, pelo incentivo e por ser um exemplo de ética e rigor na pesquisa. Ao Dr. Eurípedes Constantino Miguel por compartilhar tanto do seu conhecimento e contagiar a todos com seu entusiasmo pela pesquisa. À Dra. Roseli Shavitt por todo o apoio institucional e pelas contribuições ao longo deste trabalho. À Dra. Carolina Cappi pelas longas conversas e discussões sobre os dados, pelo convite para desenvolver este estudo na amostra do EXOMA e por fornecer a estrutura para que eu realizasse a coleta de dados. À Dra. Juliana Belo Diniz pelo suporte na discussão dos dados, por ser um exemplo inspirador de visão clínica, de rigor como pesquisadora e ótima interlocutora, sobretudo porque foi fundamental na fase final deste trabalho. À Dra. Claudia Oshiro por ter incentivado com "muita emoção" minha formação como analista do comportamento e sempre ser tão afetiva e fonte de suporte em todos os momentos. Um exemplo a ser seguido. Obrigada por todas as contribuições no exame de qualificação. À Dra. Márcia Melo Bertolla por guiar meus passos desde a graduação, um verdadeiro modelo de professora e pesquisadora. Por ter feito parte da banca do exame de qualificação, contribuindo demasiadamente com materiais que foram centrais para elaboração deste trabalho. Por ser um exemplo irretocável e inspirador nas pesquisas em psicologia, com ênfase na articulação da pesquisa com a prática. Ao Dr. Paulo Januzzi Cunha pelas contribuições a este trabalho no exame de qualificação. A todos os colegas do PROTOC, que estão de alguma maneira presentes neste trabalho, por todas as contribuições ao longo desses últimos anos, por compartilharem comigo tanto dos seus conhecimentos sobre o TOC e da psiquiatria. Ao Guaraci Requena pelo auxílio nas análises estatísticas. À minha mãe, Maria da Penha, por me inspirar como profissional, por ter me acolhido em todos os momentos, sobretudo naqueles mais difíceis e permeados por dúvidas. Por todo o zelo e preocupação. Por ter propiciado o melhor ambiente que eu poderia ter. Ao meu pai, Sérgio, por ser um exemplo de conduta, ética e persistência. E por ter sempre propiciado as melhores condições para que eu me desenvolvesse. Às amigas Thais e Val pelo carinho, confiança e amizade. Ao Danilo Bear pela escuta e pelo auxílio com as figuras. Aos amigos Raquel Paiva, Lígia Mosolino e Luiz Tadeu pela companhia desde sempre no IPUSP, nas jornadas acadêmicas, com todos os seus desafios, sempre sendo fontes de apoi...

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Harm avoidance and childhood adversities in patients with obsessive–compulsive disorder and their unaffected first‐degree relatives

Cited by 33 publications

References 80 publications

The effects of childhood emotional abuse on aggressive obsessions among patients with obsessive compulsive disorder may be mediated by symptoms of depression and anxiety

The effects of childhood emotional abuse on aggressive obsessions among patients with obsessive compulsive disorder may be mediated by symptoms of depression and anxiety

General personality dimensions, impairment and treatment response in obsessive–compulsive disorder

Experiências adversas na infância e adolescência, mediadores e transtorno obsessivo-compulsivo: um estudo com pacientes, irmãos e controles

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