Microreactor Technology and Continuous Processes in the Fine Chemical and Pharmaceutical Industry: Is the Revolution Underway?

Roberge, Dominique M.; Zimmermann, Bertin; Rainone, Fabio; Gottsponer, Michael; Eyholzer, Markus; Kockmann, Norbert

doi:10.1021/op8001273

Cited by 272 publications

(178 citation statements)

References 10 publications

(15 reference statements)

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“…Of course, the final choice on the application of some continuous flow unit operations, or the whole transformation into a continuous process should be carefully based on economical evaluation. Interesting examples relative to drug development are proposed by Roberge et al [16]. Results relative to reaction paths unrealizable in batch mode are also presented [17].…”

mentioning

confidence: 99%

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti

Compagnoni

2016

Chemical Engineering Journal

182

102

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Flow chemistry has been proposed in modern organic chemistry as a mean for process intensification, to improve the control over reaction performance and to achieve higher yield. However, many open issues can be evidenced regarding the true possibility of scale-up, as well as currently lacking information for process design and economical evaluation. This review proposes some recent examples of flow synthesis deepening in particular the scale-up and engineering issues. Required information is evidenced, as well as some transport and kinetic data required for the practical implementation of the results.

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mentioning

confidence: 99%

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Rossetti

Compagnoni

2016

Chemical Engineering Journal

182

102

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“…Microfluidic devices have found widespread applications in the area of organic synthesis, for development of novel synthesis methods and routes [37,38]. In some cases, they have also been used for actual manufacturing of fine chemicals and pharmaceuticals [37,39,40].…”

Section: A Microfluidic Toolbox For Ispr Developmentmentioning

confidence: 99%

“…It is important to point out that the continuous-flow nature of microfluidics makes this technology suitable for development of continuous process concepts [38,54,55]. Continuous processes are recognized to give benefits such as reduced down-times, increased space-time yields, steadystate operation, improved heat, and mass transfer control, to name a few [56][57][58].…”

Section: A Microfluidic Toolbox For Ispr Developmentmentioning

confidence: 99%

A microfluidic toolbox for the development of in-situ product removal strategies in biocatalysis

Heintz¹,

Mitić²,

Ringborg³

et al. 2016

Journal of Flow Chemistry

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A microfluidic toolbox for accelerated development of biocatalytic processes has great potential. This is especially the case for the development of advanced biocatalytic process concepts, where reactors and product separation methods are closely linked together to intensify the process performance, e.g., by the use of in-situ product removal (ISPR). This review provides a general overview of currently available tools in a microfluidic toolbox and how this toolbox can be applied to the development of advanced biocatalytic process concepts. Emphasis is placed on describing the possibilities and advantages of the microfluidic toolbox that are difficult to achieve with conventional batch-processbased technologies. Application of this microfluidic toolbox will potentially make it possible to intensify biocatalytic reactions and thereby facilitate the development towards novel and advanced biocatalytic processes, which in many cases have proven too difficult in conventional batch equipment.

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“…54 Gas-liquid reactions catalyzed by solids represent a very important class of reactions. They may be carried out in either slurry (such as bubble column, stirred tank, and gas-liquid MSR process development and demonstration of industrial production Merck, 17 SK Chemicals, 18 Ampac Fine Chemicals, 19 Phoenix Chemicals, 20 Clariant GmbH, 21 DSM, 16,22,23 Lonza, 24,25 Sigma-Aldrich fluidized configurations) or fixed-bed reactors (trickle bed with cocurrent downflow or cocurrent upflow, segmented bed, and countercurrent gas-liquid arrangements). The hydrodynamics in three phase reactors are extremely complex due to the three phases and their convoluted interactions.…”

Section: Conventional Multiphase Reactorsmentioning

confidence: 99%

Microstructured Reactors for Multiphase Reactions: State of the Art

Kashid

Kiwi‐Minsker

2009

Ind. Eng. Chem. Res.

194

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The manufacture of chemicals in microstructured reactors (MSR) has become recently a new branch of chemical reaction engineering focusing on process intensification and safety. MSR have an equivalent hydraulic diameter up to a few hundreds of micrometers and, therefore, provide high mass-and heat-transfer efficiency increasing the reactor performance drastically, compared to the conventional one. This article provides a comprehensive overview of the state of the art of the MSR applied for multiphase reactions. The reactions are classified based on the number of phases involved: fluid-fluid, fluid-solid, and three phase reactions. In the first part of the review, limitations of conventional reactors are discussed in brief. Furthermore, different types of MSR and their advantages with respect to their conventional counterparts are described. Particular attention is given to the identification of the parameters that control the flow pattern formed in microcapillaries regarding the mass-transfer efficiency. Case studies of various multiphase reactions carried out in MSR are discussed in detail.

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Microreactor Technology and Continuous Processes in the Fine Chemical and Pharmaceutical Industry: Is the Revolution Underway?

Cited by 272 publications

References 10 publications

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

A microfluidic toolbox for the development of in-situ product removal strategies in biocatalysis

Microstructured Reactors for Multiphase Reactions: State of the Art

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