Microreactor and electrochemical detectors fabricated using Si and EPON SU-8

L'Hostis, E.; Michel, Ph.; Fiaccabrino, G. C.; Strike, D. J.; Rooij, N. F. de; Koudelka‐Hep, M.

doi:10.1016/s0925-4005(99)00500-6

Cited by 83 publications

(44 citation statements)

References 17 publications

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“…The intensity of the red luminescence observed on the electrode is measured by an external photodiode. Several groups have already integrated the electrodes and a detecting photodiode, which is easily realized with the present semiconductor technology [54,60,61,[144][145][146]. Furthermore, one of the advantages of micro-electrochemical systems is that the integration of the circuits is possible as an option.…”

Section: Towards Autonomous Microsystemsmentioning

confidence: 99%

Electrochemical techniques for microfluidic applications

et al. 2008

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Electrochemical principles provide key techniques to promote the construction of bio/chemical microsystems of the next generation. There is a wealth of technology for the microfabrication of bio/chemical sensors. In addition, microfluidic transport in a network of flow channels, pH regulation, and automatic switching can be realized by electrochemical principles. Since the basic components of the devices are electrode patterns, the integration of different components is easily achieved. With these techniques, bio/chemical assays that require the exchange of solutions can be conducted on a chip. Furthermore, autonomous microanalysis systems that can carry out necessary procedures are beginning to be realized. In this article, techniques developed in our group will be comprehensively introduced.

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Section: Towards Autonomous Microsystemsmentioning

confidence: 99%

Electrochemical techniques for microfluidic applications

et al. 2008

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“…Immobilized enzymes have been used as component of detection device in various analytical and biomedical applications [19,20,[60][61][62][63] including glucose and penicillin. Some of these devices have been associated with miniaturized electrochemical detectors and fluidic systems.…”

Section: Immobilized Enzyme Biosensorsmentioning

confidence: 99%

“…Some of these devices have been associated with miniaturized electrochemical detectors and fluidic systems. L'Hostis et al [19] tested the enzymatic microreactor for glucose detection via glucose oxidase immobilized to glass beads. Glucose detection was carried out by electrochemical measurements of hydrogen peroxide generated enzymatically with a platinum electrode.…”

Section: Immobilized Enzyme Biosensorsmentioning

confidence: 99%

Immobilized microfluidic enzymatic reactors

2004

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The use of enzymes for cleavage, synthesis or chemical modification represents one of the most common processes used in biochemical and molecular biology laboratories. The continuing progress in medical research, genomics, proteomics, and related emerging biotechnology fields leads to exponential growth of the applications of enzymes and the development of modified or new enzymes with specific activities. Concurrently, new technologies are being developed to improve reaction rates and specificity or perform the reaction in a specific environment. Besides large-scale industrial applications, where typically a large processing capacity is required, there are other, much lower-scale applications, benefiting form the new developments in enzymology. One such technology is microfluidics with the potential to revolutionize analytical instrumentation for the analyses of very small sample amounts, single cells or even subcellular assemblies. This article aims at reviewing the current status of the development of the immobilized microfluidic enzymatic reactors (IMERs) technology.

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“…Several bead immobilization approaches have been reported, including mechanical trapping [3][4][5][6], magnetic manipulation [7][8][9][10], and dielectrophoresis (DEP) retention [2,[11][12][13]. For the single-beadbased biochemical assay described in this paper, we immobilized a single bead at the center of a set of trapping electrodes on a microfluidic chip using a negative DEP force.…”

Section: Introductionmentioning

confidence: 99%