Electrochemical techniques for microfluidic applications

Sassa, Fumihiro; Morimoto, Koichi; Satoh, Wataru; Suzuki, Hiroaki

doi:10.1002/elps.200700581

Cited by 74 publications

(54 citation statements)

References 145 publications

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“…16 Within the Lab-on-a-Chip systems field, extensive work has been done in integrating electrochemical detection. [17][18][19][20][21] However, despite the previously mentioned advantages of having electric contact to a microfluidic system, only few examples of centrifugal microfluidic platforms interfaced with electrical connections have been reported in the literature. [22][23][24][25][26] These examples are based on one of two different options:…”

Section: Introductionmentioning

confidence: 99%

Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing

et al. 2015

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Abstract. Here we present a robust, stable and low-noise experimental set-up for performing electrochemical detection on a centrifugal microfluidic platform. By using a low-noise electronic component (electrical slipring) it is possible to achieve continuous, on-line monitoring of electrochemical experiments, even when the microfluidic disc is spinning at high velocities. Automated sample handling is achieved by designing a microfluidic system to release analyte sequentially, utilizing on-disc passive valving. In addition, the microfluidic system is designed to trap and keep the liquid sample stationary during analysis. In this way it is possible to perform cyclic voltammetry (CV) measurements at varying spin speeds, without altering the electrochemical response. This greatly simplifies the interpretation and quantification of data. Finally, real-time and continuous monitoring of an entire electrochemical experiment, including all intermediate sample handling steps, is demonstrated by amperometric detection of on-disc mixing of analytes (PBS and ferricyanide).

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Section: Introductionmentioning

confidence: 99%

Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing

et al. 2015

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“…Among them, microfluidic transport is a critical application, and the technique has been actively incorporated in various forms in a trend of research relating to the micrototal analysis system or laboratory-on-a-chip. [2][3][4] In microfluidic systems, most of the devices proposed earlier have mainly focused on the transport of droplets and were based on the so-called electrowetting-on-dielectric using an array of electrodes covered with an insulating layer. [4][5][6][7][8][9][10][11][12] However, these systems required high voltage to control the interfacial tension.…”

Section: Introductionmentioning

confidence: 99%

Electrowetting on gold electrodes with microscopic three-dimensional structures for microfluidic devices

Yokomaku

Satoh

Fukuda

et al. 2008

Journal of Applied Physics

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To improve the performance of electrowetting-based microfluidic devices, we used micropillar structures to enhance the changes in the wettability of gold electrodes. The changes in the contact angle of a sessile drop were influenced by the diameter of the micropillars and interpillar distances. For a potential change between 0 V and −1.0 V, the change of the contact angle of the KCl sessile drop was 41°on a smooth electrode, but 88°on an electrode with micropillars with a 10 m diameter. Furthermore, the existence of the micropillars accelerated the change of the contact angle. The gold electrodes with the micropillars were used to generate the capillary force to mobilize a liquid column in a microflow channel. Compared to a device with a smooth electrode, this device showed a fourfold increase in the flow velocity at −0.9 V. The electrodes were also used as a valve. The ability to stop an intruding solution and the switching speed was improved with the micropillar structure.

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“…Several detection methods, for example, fluorescence, UV-vis, FT-IR, and mass spectrometry, are not suitable as portable diagnostic tools in microfluidics, because it is difficult to reduce the size of their detection modules. In contrast, electrochemical detection is suitable for portable devices, because it is easier to miniaturize each part -electrochemical station, electrochemical cells, and electrodes -of an electrochemical system [4,5]. The qualitative identification of substances such as metal ions is dependent on the characteristic redox potentials of the substances and, in order to measure accurately the electrode potentials on chip, it is important to develop a reliable miniaturized reference electrode.…”

Section: Introductionmentioning

confidence: 97%

Fabrication of a microfluidic Ag/AgCl reference electrode and its application for portable and disposable electrochemical microchips

et al. 2010

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This report describes a convenient method for the fabrication of a miniaturized, reliable Ag/AgCl reference electrode with nanofluidic channels acting as a salt bridge that can be easily integrated into microfluidic chips. The Ag/AgCl reference electrode shows high stability with millivolt variations. We demonstrated the application of this reference electrode in a portable microfluidic chip that is connected to a USB-port microelectrochemical station and to a computer for data collection and analysis. The low fabrication cost of the chip with the potential for mass production makes it disposable and an excellent candidate for real-world analysis and measurement. We used the chip to quantitatively analyze the concentrations of heavy metal ions (Cd(2+) and Pb(2+)) in sea water. We believe that the Ag/AgCl reference microelectrode and the portable electrochemical system will be of interest to people in microfluidics, environmental science, clinical diagnostics, and food research.

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Electrochemical techniques for microfluidic applications

Cited by 74 publications

References 145 publications

Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing

Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing

Electrowetting on gold electrodes with microscopic three-dimensional structures for microfluidic devices

Fabrication of a microfluidic Ag/AgCl reference electrode and its application for portable and disposable electrochemical microchips

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