Microplastics detected in cirrhotic liver tissue

Horvatits, Thomas; Tamminga, Matthias; Liu, Beibei; Sebode, Marcial; Carambia, Antonella; Fischer, Lutz; Püschel, Klaus; Huber, Samuel; Fischer, Elke Kerstin

doi:10.1016/j.ebiom.2022.104147

Cited by 213 publications

(96 citation statements)

References 52 publications

(69 reference statements)

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“…The findings reported by Horvatits et al 8 in this issue of eBioMedicine add to the previous results of microplastic accumulation in human organs and tissues. Although this work should be taken with caution due to the small sample size, it takes a step forward in our understanding of the potential negative effect of microplastic accumulation.…”

supporting

confidence: 84%

Should we worry about the accumulation of microplastics in human organs?

Sorci

Loiseau²

2022

eBioMedicine

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supporting

confidence: 84%

Should we worry about the accumulation of microplastics in human organs?

Sorci

Loiseau²

2022

eBioMedicine

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“…The hiPSC-derived DOs allowed us to evaluate the hepatotoxicity of environmental toxicants in the context of individual inheritance. MPs were detected in human cirrhosis liver tissues 3 . In the DOs, MPs not only accumulated but were also internalized by cells and appeared in the nuclear region.…”

Section: Discussionmentioning

confidence: 96%

“…Five of six patients whose liver tissues accumulated MPs suffered ALD 3 . Given the accumulation in cirrhotic liver, the effect of MPs in liver disease remains elusive, i.e., whether they are a contributor or a consequence.…”

Section: Mp-tbbpa Complexes Exhibit Hepatotoxicity To Ald Patient-der...mentioning

confidence: 99%

“…Daily environmental exposure to MPs and their potential effects on human health have raised public concerns in recent years. MPs (<10 µm) were detected in the blood of healthy individuals 1 and the placenta 2 and accumulated in human cirrhotic liver tissues 3 . Besides, MPs as vectors transfer plastic additives and toxicants in the environment into the body, thus causing combined toxicity 4 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Toxicity of microplastics and plastic additive co-exposure in liver Disse organoids from healthy donors and patient-derived induced pluripotent stem cells

Liang

Luo

et al. 2022

Preprint

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The ubiquitous microplastics (MPs) and plastic additives in the environment usually form complexes, enter human blood circulation, and increase the risk of steatohepatitis. The liver Disse space plays a vital role in corresponding hepatic pathological processes. However, due to the limited understanding of the regulatory cues in multilineage maturation, the generation of large-scale Disse-like organoids (DOs) mirroring the comprehensive toxicity responses of MPs is challenging. Here, using human-induced pluripotent stem cells (hiPSCs), we biofabricated healthy donors and patient-derived DOs containing hepatocytes, endothelial cells, and hepatic stellate cells, resembling the features of Disse space. These organoids revealed that polystyrene MPs preferentially entered endothelial cells and then dispersed throughout the organoids, similar to reported studies in zebrafish. Co-exposure to MPs and tetrabromobisphenol A (TBBPA), a common plastic additive, showed enhanced accumulation of contamination in the organoids. We also biofabricated alcoholic liver disease (ALD) patient-derived DOs representing the specific disease transcriptional profiles. We found that co-exposure to MPs and TBBPA at environmental-related dosages significantly elevated the pathological transcriptional expression and biochemical profiles in patient-derived DOs but not in healthy organoids, suggesting that both hereditary factors and pollutants contribute to susceptibility to environmental toxicants. This study exemplified the value of biofabricated hiPSC-derived organoids in environmental toxicology and offered a powerful strategy for personalized toxicology evaluation.

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“…Industrial exposures to microplastic fibers in textile workers are linked to lung diseases [ 37 ]. Microplastic particles are reported to have been detected in cirrhotic liver tissue in liver transplant patients [ 46 ]. The microplastic load in feces is reported to be associated with inflammatory bowel disease status [ 49 ].…”

mentioning

confidence: 99%