Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningococcal septic shock

Hellum, Marit; Øvstebø, Reidun; Brusletto, Berit; Berg, Jens Petter; Brandtzæg, Petter; Henriksson, Carola E.

doi:10.1016/j.thromres.2013.12.031

Cited by 50 publications

(45 citation statements)

References 32 publications

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“…51 Tissue factorbearing microparticles contribute to the pathogenesis of disseminated intravascular coagulation. 52 Severely reduced protein C activity is Shown are photographs and laboratory results for a 23-year-old woman with endocarditis caused by Staphylococcus aureus that resulted in combined septic and cardiogenic shock. The patient's condition was complicated by acute ischemic hepatitis ("shock liver") along with respiratory and renal failure.…”

Section: Meningococcemiamentioning

confidence: 99%

Ischemic Limb Gangrene with Pulses

2015

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Section: Meningococcemiamentioning

confidence: 99%

Ischemic Limb Gangrene with Pulses

2015

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“…Consequently, the specific analysis of the proteome and the nucleic acid present in EVs may offer information about the cell or tissue of origin and, especially, their physiological condition. Recently, many studies underlined the important role of EVs in inflammation, coagulation, vascular function, and their physiological and pathological effects during sepsis; they may represent important contributors to multiorgan failure in septic shock [63,64,65,66]. …”

Section: Role Of Microrna In Lps/tlr4 Signalingmentioning

confidence: 99%

Endotoxin Effects on Cardiac and Renal Functions and Cardiorenal Syndromes

et al. 2017

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Gram-negative sepsis is a major cause of morbidity and mortality in critical ill patients. Recent findings in molecular biology and in signaling pathways have enhanced our understanding of its pathogenesis and opened up opportunities of innovative therapeutic approaches. Endotoxin plays a pivotal role in the pathogenesis of multi-organ dysfunction in the setting of gram-negative sepsis. Indeed, heart and kidney impairments seem to be induced by the release of circulating pro-inflammatory and pro-apoptotic mediators triggered by endotoxin interaction with immune cells. These molecules are responsible for cellular apoptosis, autophagy, cell cycle arrest, and microRNAs activation. Therefore, the early identification of sepsis-associated acute kidney injury and heart dysfunction may improve the patient clinical outcome. In this report, we will consider the role of endotoxin in the pathogenesis of sepsis, its effects on both cardiac and renal functions, and the interactions between these 2 systems in the setting of cardiorenal syndromes (CRS), particularly in CRS type 5. Finally, we will discuss the possible role of extracorporeal therapies in reducing endotoxin levels.

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“…Similarly, microparticle TF activity correlates to bacterial LPS load (Hellum et al, 2014) and is associated with coagulation activation in endotoxemic mice (Wang et al, 2009). This indicates that TF antigen measurement could serve as a diagnostic and prognostic biomarker in patients with cancer or bacterial infections.…”

Section: Introductionmentioning

confidence: 93%