Micronutrient Supplementation and Infection: A Double-Edged Sword?

Doherty, Conor; Weaver, Lawrence T.; Prentice, Andrew M.

doi:10.1097/00005176-200204000-00004

Cited by 33 publications

(29 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several enzymes such as glutathione, peroxidase, catalase and dehidrogenase need the iron as a free radical antidote. 7,12 The improvement of veins permeability causing a leak, transferin to interstitial fluid. Iron triggers bacterial growth because of its role as an essential nutrients for the growth of bacteria.…”

Section: Iron (Fe)mentioning

confidence: 99%

See 1 more Smart Citation

Micronutrient Therapy for Sepsis

Prasetiyo

Nasronudin

2015

Indonesian J. of Tropical and Infectious Dis.

View full text Add to dashboard Cite

Section: Iron (Fe)mentioning

confidence: 99%

“…It happens because of the production of free radicals are increasing and damage the peroxydases fat located in phagosom membrane. 12 Iron is also a growth factor for some bacteria and increase proliferation thoroughly in vivo. Granting iron in parenteral way can inhibit the migration of neutrophi and weaken the host defensibility.…”

Section: Iron (Fe)mentioning

confidence: 99%

Micronutrient Therapy for Sepsis

Prasetiyo

Nasronudin

2015

Indonesian J. of Tropical and Infectious Dis.

View full text Add to dashboard Cite

“…Iron overload with administration of extracellular haemoglobin could be a concern, particularly since this might compromises the immune function -in experimental animal models, the mortality has been increased after iron supplementation [69][70][71].…”

Section: Modified Haemoglobin Solutionsmentioning

confidence: 99%

Haemoglobin, oxygen carriers and perioperative organ perfusion

Kocián¹,

Spahn²

2008

Best Practice & Research Clinical Anaesthesiology

View full text Add to dashboard Cite

show abstract

“…Iron deficiency as well as iron overload compromises immune function [64] and high iron supplementation may increase mortality of experimental sepsis models in mice [65,66]. It is therefore conceivable that with the use of massive amounts of hemoglobin based oxygen carriers sufficient iron is being administered to have a negative impact on outcome in septic subjects.…”

Section: Hemoglobin Solutionsmentioning

confidence: 99%

Artificial O2 Carriers: Status in 2005

Spahn¹,

Kocián²

2005

CPD

View full text Add to dashboard Cite

Donor blood is a limited resource and its transfusion is associated with significant adverse effects. Therefore, alternatives have been searched, the ultimate being artificial oxygen (O2) carriers. There are two main groups of artificial O2 carriers: hemoglobin based and perfluorocarbon emulsions. The hemoglobin molecule in hemoglobin based artificial O2 carriers needs to be stabilized to prevent dissociation of the alpha2beta2-hemoglobin tetramer into alphabeta-dimers in order to prolong intravascular retention and to eliminate nephrotoxicity. Other modifications serve to decrease O2 affinity in order to improve O2 off-loading to tissues. In addition, polyethylene glycol may be surface conjugated to increase molecular size. Finally, certain products are polymerized to increase the hemoglobin concentration at physiologic colloid oncotic pressure. Perfluorocarbons are carbon-fluorine compounds characterized by a high gas dissolving capacity for O2 and CO2 and chemical and biologic inertness. Perfluorocarbons are not miscible with water and therefore need to be brought into emulsion for intravenous application. Development, product specification, physiologic effects, efficacy to decrease the need for donor blood in surgery and side effects of the following products are described: Diaspirin cross-linked hemoglobin (HemAssist), human recombinant hemoglobin (rHb1.1 and rHb2.0), polymerized bovine hemoglobin-based O2 carrier (HBOC-201), human polymerized hemoglobin (PolyHeme), hemoglobin raffimer (Hemolink), maleimide-activated polyethylene glycol-modified hemoglobin (MP4) and perflubron emulsion (Oxygent). In addition, enzyme cross-linked poly-hemoglobin, hemoglobin containing vesicles (nano-dimension artificial red blood cells) and an allosteric modifier (RSR13) are discussed. The most advanced products are in clinical phase III trials but no product has achieved market approval yet in the US, Europe or Canada.

show abstract

Micronutrient Supplementation and Infection: A Double-Edged Sword?

Cited by 33 publications

References 49 publications

Micronutrient Therapy for Sepsis

Micronutrient Therapy for Sepsis

Haemoglobin, oxygen carriers and perioperative organ perfusion

Artificial O2 Carriers: Status in 2005

Contact Info

Product

Resources

About