Micronutrient status (calcium, zinc, vitamins D and E) in patients with medullary thyroid carcinoma: A cross-sectional study

Emami, Ali; Nazem, Mohammad Reza; Shekarriz, R; Hedayati, Mehdi

doi:10.1016/j.nut.2017.04.004

Cited by 20 publications

(13 citation statements)

References 39 publications

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“…In more than 10% of the population, intake of zinc with meals is less than half the recommended dose, and chronic zinc deficiencies significantly increase the risk of cancer [10,12,13]. Many patients with cancer, especially of the lungs, breast, head, and neck, have a decreased level of zinc in the blood [14,15,16,17,18,19,20,21,22]. Due to the multitude of functions performed by this element, it can be assumed to play a leading role in defending against the initiation and promotion of tumors, although the mechanism of this role is not fully known [23].…”

Section: Introductionmentioning

confidence: 99%

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

2019

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The human body cannot store zinc reserves, so a deficiency can arise relatively quickly, e.g., through an improper diet. Severe zinc deficiency is rare, but mild deficiencies are common around the world. Many epidemiological studies have shown a relationship between the zinc content in the diet and the risk of cancer. The anti-cancer effect of zinc is most often associated with its antioxidant properties. However, this is just one of many possibilities, including the influence of zinc on the immune system, transcription factors, cell differentiation and proliferation, DNA and RNA synthesis and repair, enzyme activation or inhibition, the regulation of cellular signaling, and the stabilization of the cell structure and membranes. This study presents selected issues regarding the current knowledge of anti-cancer mechanisms involving this element.

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Section: Introductionmentioning

confidence: 99%

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

2019

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“…Our data suggest adjusted serum calcium levels may be lower in PHPT patients with thyroid cancer, although no statistical difference was observed compared to patients with benign nodules, or without nodules ( P = 0.129). A small cross-sectional study consisting of 40 medullary thyroid cancer patients and 40 healthy controls showed a low serum calcium level was a potent risk factor for medullary thyroid cancer ( 28 ). And a case-control study including 1092 participants, indicated that lower serum calcium levels were an independent predictor of thyroid nodules among patients with type 2 diabetes mellitus (adjusted OR = 1.98, 95% CI 1.66–2.84) ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Increased thyroid malignancy in patients with primary hyperparathyroidism

et al. 2021

Endocrine Connections

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Background: Multiple studies have reported increased incidence of thyroid cancer in patients with primary hyperparathyroidism (PHPT). However, the underlying risk factors of concomitant thyroid cancer in patients with PHPT remain unknown. The primary aim of this study was to examine the records of patients with PHPT to identify characteristics that correlated with the presence of coexisting thyroid nodules, and which may have an implication for the prediction of thyroid cancer. Methods: Medical records of consecutive patients with PHPT (n=318) were reviewed from Jan 2010 to Sep 2020 in two tertiary medical centers in China. Patient clinicopathological and biological data were collected and analyzed. Results: Of a total of 318 patients with PHPT, 105 (33.0%) patients had thyroid nodules and 26 (8.2%) patients were concomitant with thyroid cancer. A total of 38 thyroid nodules taken from 26 patients were pathologically assessed to be well-differentiated papillary thyroid carcinoma (PTC), with 81% being papillary thyroid microcarcinoma (PTMC). In 79% (30/38) of these cancers, thyroid nodules were considered suspicious following preoperative ultrasound. Multinomial logistic regression analysis revealed that female gender was associated with increased risk of thyroid nodules (OR=2.13, 95%CI: 1.13-3.99, p = 0.019), while lower log-transformed parathyroid hormone levels were an independent predictor of thyroid cancer in patients with PHPT (OR=0.50, 95%CI: 0.26-0.93, p = 0.028). Conclusion: In conclusion, we observed a relatively high prevalence of thyroid cancer in our cohort of Chinese patients with PHPT. Evaluation of thyroid nodules by preoperative ultrasound may be advisable in patients with PHPT, particularly for females and patients with modestly elevated serum parathyroid hormone levels.

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“…По оценкам экспертов, примерно 17% населения мира имеют недостаточность или дефицит цинка, при этом наибольший процент приходится на Африку (24%) и Азию (19,5%) [14,15]. Недостаточность цинка довольно широко распространена и в европейских странах [12,13].…”

Section: влияние дефицита цинка на функцию щитовидной железы его взаunclassified

The role of zinc in the synthesis and metabolism of thyroid hormones

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2021

Clin Exp Thyroid

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About one third of the world’s population is deficient in one or more micronutrients, with the most common deficiencies in iodine, iron, zinc, vitamin A and folate. Deficiency of one or more essential vitamins and minerals is usually the result of poor nutrition and / or insufficient absorption of micronutrients as a result of infectious and inflammatory diseases. It is possible that the deficiency of certain trace elements, in turn, can aggravate iodine deficiency and contribute to dysfunction of the thyroid gland. There are assumptions about the relationship between the content of iodine, selenium, iron, zinc in the human body and the level of thyroid hormones. Zinc is a vital trace element for all living organisms, participating in many biochemical processes in cells, including cell differentiation and division, its growth, cell transport, transcription, protein synthesis, RNA and DNA synthesis, and DNA replication. Its role as an antioxidant and participation in the functioning of both innate (T, NK and NKT cells) and adaptive immunity (anti-inflammatory cytokines) are very important. This review will consider the role of zinc in the synthesis and metabolism of thyroid hormones.

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Micronutrient status (calcium, zinc, vitamins D and E) in patients with medullary thyroid carcinoma: A cross-sectional study

Cited by 20 publications

References 39 publications

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

Increased thyroid malignancy in patients with primary hyperparathyroidism

The role of zinc in the synthesis and metabolism of thyroid hormones

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