Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

Skrajnowska, Dorota; Bobrowska-Korczak, Barbara

doi:10.3390/nu11102273

Cited by 224 publications

(161 citation statements)

References 225 publications

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“…Especially important are vitamin D3 (cholecalciferol), 25-hydroxyvitamin D3 (calcidiol) and 1,25 dihydroxy vitamin D3 (calcitriol; the necessary active metabolic form). Vitamin D also has anti-cancer properties by working to increase cell maturation and differentiation, inducing apoptosis, and down-regulation of telomerase 16 . In this patient, although vitamin D examination was not carried out, administration of the drug OAT (Rifampicin) is known to accelerate the breakdown of vitamin D caused by the induction of the CYP450 enzyme.…”

Section: Discussionmentioning

confidence: 99%

Nutrition Therapy on Cutaneous Lymphoma Patient with Anemia and Hypoalbuminemia: A Case Report

Tyas¹,

As’ad²,

Safitri³

et al. 2020

GMJ

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Nutrition is a part of cancer management during therapy, recovery, remission, and recurrence prevention. Malnutrition and cachexia often occur in cancer patients and influence morbidity, mortality, and quality of life, especially in the advanced stage of malignancy. We reported a case of cutaneous lymphoma with anemia and hypoalbuminemia in the terminal condition. This case report focuses on nutritional therapy and palliative care on nutrition. We reported a case of a 40-year-old-man with Cutaneous Lymphoma (CL) and moderate protein-energy malnutrition that was developed to severe protein-energy malnutrition due to difficulty in dietary access. He had an eating problem because of multiple tumors and ulcers on his mouth. We provided access for parenteral nutrition from Central Venous Catheter (CVC) and orogastric tube (OGT) for enteral feeding. Even though the dietary target was never accomplished, there was a slight recovery on hypoalbuminemia and renal function during hospitalization. This case showed a considerable challenge in nutritional therapy due to limited dietary access. Since death was inevitable, we have tried different dietary access to provide adequate intake.

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Section: Discussionmentioning

confidence: 99%

Nutrition Therapy on Cutaneous Lymphoma Patient with Anemia and Hypoalbuminemia: A Case Report

Tyas¹,

As’ad²,

Safitri³

et al. 2020

GMJ

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“…Though the mechanisms through which Zn contributes to balancing the redox are still partially known and the subject of active research. Most commonly, the Zn deficiency is known to disrupt p53 function [ 105 ] and disturb the cellular redox in esophageal, head, and neck cancer cells [ 106 , 107 , 108 , 109 , 110 ]…”

Section: Mitocans: the Alternative Cancer Therapymentioning

confidence: 99%

Natural Agents Targeting Mitochondria in Cancer

Mani,

Swargiary,

Singh

2020

IJMS

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Mitochondria are the key energy provider to highly proliferating cancer cells, and are subsequently considered one of the critical targets in cancer therapeutics. Several compounds have been studied for their mitochondria-targeting ability in cancer cells. These studies’ outcomes have led to the invention of “mitocans”, a category of drug known to precisely target the cancer cells’ mitochondria. Based upon their mode of action, mitocans have been divided into eight classes. To date, different synthetic compounds have been suggested to be potential mitocans, but unfortunately, they are observed to exert adverse effects. Many studies have been published justifying the medicinal significance of large numbers of natural agents for their mitochondria-targeting ability and anticancer activities with minimal or no side effects. However, these natural agents have never been critically analyzed for their mitochondria-targeting activity. This review aims to evaluate the various natural agents affecting mitochondria and categorize them in different classes. Henceforth, our study may further support the potential mitocan behavior of various natural agents and highlight their significance in formulating novel potential anticancer therapeutics.

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“…Zinc is vital for normal development and function of cells mediating innate immunity, NK cells and neutrophils [17]. Zinc deficiency affects multiple aspects of the immune system, from the barrier of the skin to gene regulation within lymphocytes [18].…”

Section: Role Of Zinc In Immune Systemmentioning

confidence: 99%

Zinc Supplementation Prevents the Complications of COVID-19 Infection in Cancer Patients

Derouiche

2020

Asian Pac J Cancer Care

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Novel coronavirus” SARS-CoV-2 is rapidly spreading worldwide with a significant mortality rate. In the crisis of COVID-19, cancer patients are seen as a very weak group and this is because of their weakened immune system and hence we aim in this research to show the importance of zinc as a buffer against cancer in COVID-19 for cancer patients. Zinc is an essential trace element that is crucial for growth, development, and the maintenance of immune function. zinc supplementation decreased and generation of inflammatory cytokines. zinc supplementation should have beneficial effects on cancer by decreasing oxidative stress, angiogenesis and induction of inflammatory cytokines while increasing apoptosis in cancer cells. zinc supplementation implemented to improve the antiviral response and systemic immunity in patients with cancer diseases. With the multiple doses approved from zinc, we suggest that there be an supplement in zinc by 50 mg / day for three month with each treatment for cancer patients, in order to strengthen the immune system to prevent the serious effects of COVID19 infection.

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Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

Cited by 224 publications

References 225 publications

Nutrition Therapy on Cutaneous Lymphoma Patient with Anemia and Hypoalbuminemia: A Case Report

Nutrition Therapy on Cutaneous Lymphoma Patient with Anemia and Hypoalbuminemia: A Case Report

Natural Agents Targeting Mitochondria in Cancer

Zinc Supplementation Prevents the Complications of COVID-19 Infection in Cancer Patients

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