Micronutrient malnutrition and the pathogenesis of malarial anemia

Nussenblatt, Véronique; Semba, Richard D.

doi:10.1016/s0001-706x(02)00049-9

Cited by 61 publications

(45 citation statements)

References 105 publications

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“…As a matter of fact, anemia in black African subjects usually results from combination between nutritional deficiency, iron losses due to intestinal parasites, hemolysis caused by malaria infections and genetic factors (Nussenblatt & Semba, 2002). The menstrual blood loss and the worsening of the renal function constitute other factors which may induce an abnormal decrease of plasma hemoglobin in these post-pubescent girls.…”

Section: Discussionmentioning

confidence: 99%

Renal Responses to a Series of Handball Games Played in Sub-Saharan Environment by Amateur Division 1 of Female Players

Tonon¹,

Agboton²,

Falola³

et al. 2012

APE

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This study aims at assessing the modifications of renal parameters with 13 female players of the same Benin team-amateur Division 1, during two consecutive handball games played 26 hours apart. The players are divided into two groups: starters (ST: N = 7) and nonstarters (NS: N = 6). The estimated glomerular filtration rate (eGFR) with Cockcroft-Gault and MDRD formulas, the fractional excretion of sodium (FeNa), the plasma haemoglobin (Hb) and albumin (Alb) were assayed at rest and at the end of each game. At the end of the first game, only eGFR decreased significantly by at least 16.30% (p < 0.05) in ST only. At the end of the second game, the average reductions of eGFR are significant in both the ST and NS groups (p < 0.05), but they are less important than those recorded at the end of the first (p > 0.05). FeNa varied in no group, neither after the first game, nor after the second (p > 0.05). But a cumulative reduction is observed between the values before the first and those recorded at the end of the second game in both ST and NS groups. The status of the players (ST or NS) did not influence the results. Two games of handball played 26 hours apart in the sub-Saharan environment of Cotonou caused in girls, a transitory decrease in eGFR without a cumulative effect. FeNa decreased too, but with a cumulative effect which indicates large sodium retention.

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Section: Discussionmentioning

confidence: 99%

Renal Responses to a Series of Handball Games Played in Sub-Saharan Environment by Amateur Division 1 of Female Players

Tonon¹,

Agboton²,

Falola³

et al. 2012

APE

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“…It has been reported that individuals with malaria have lower plasma concentrations of several micronutrients when compared to controls [23]. This decrease in iron levels during acute malaria has been attributed to immobilization of iron in haemazoin complexes and reduction in intestinal iron absorption [24].…”

Section: Discussionmentioning

confidence: 99%

The burden of malaria and malnutrition among children less than 14 years of age in a rural village of Cameroon

Nkuo‐Akenji¹,

Sumbele²,

Mankah³

et al. 2008

African Journal of Food, Agriculture, Nutrition and Development

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Malaria and malnutrition are a major health burden in developing countries with infants and children being the most vulnerable groups. The extent of the burden of malaria and malnutrition was investigated in 339 children ≤14years residing in the village of Muea located in the South West Province of Cameroon. Malaria parasitaemia was determined microscopically from Giemsa stained thick blood films. Nutritional status was determined using age and the anthropometric parameters of weight and height. Height-for-age (HAZ), weight-for-age (WAZ) and weight-forheight (WHZ) Z scores were computed based on the National Centre for Health Statistics (NCHS)/World Health Organisation growth reference curves. Anaemia was assessed by measuring haemoglobin (Hb) concentration while plasma iron levels were determined by spectrophotometric assays. The prevalence of malaria in the study population was 96.2% (326/339) with a majority (68.4%) having asymptomatic disease. The geometric mean parasite density (GMPD) was 744.37 ± 89396.11 (parasitaemia range 40-153190 parasites/µL blood). The mean Hb concentration was 9.29 ± 1.8g/dL (range 4-14.1g/dL) and anaemia (Hb<11g/dL) was diagnosed in 81.4% of the children, a majority of whom had microcytic anaemia. A negative correlation was observed between parasite density and haemoglobin concentration (r = -0.14). The mean plasma iron level was 53.64 ± 32.87µL/dl (range 1.8-159) with 58.7% (199/339) of the children diagnosed as iron deficient (plasma iron concentrations <50µg/dL). A negative correlation was observed between plasma iron values and malaria parasitaemia (r = -0.031). The prevalence of malnutrition was 58.1% (197/339). Of the 197 malnourished children, 23.6% were wasted (< -2 SD weight-for-height Z-score), 26.5% underweight (< -2 SD weight-for-age Z score) and 49.9% stunted (< -2 SD height-for-age Z score). There was a negative correlation between nutritional status and malaria parasitaemia (r =-0.034). The findings from this study are strongly suggestive that falciparum malaria and malnutrition exist in children residing in Muea and constitute a major health problem which needs to be immediately addressed to reduce morbidity and mortality.

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“…In the developing world, a host of factors play a role, most notably micronutrient deficiencies (especially iron deficiency), parasitic infections (particularly malaria and intestinal nematodes such as hookworms), infection with human immunodeficiency virus (HIV), chronic inflammatory disorders, and hemoglobinopathies. [1][2][3][4][5][6] Recent literature reviews have established the causal relationship between malaria and anemia. Communitybased malaria control interventions, including antimalarial chemoprophylaxis, use of insecticide-treated nets (ITNs), and indoor residual spraying, consistently improved anemiarelated outcomes in young children.…”

Section: Introductionmentioning

confidence: 99%

Modeling the Relationship Between the Population Prevalence of Plasmodium Falciparum Malaria and Anemia

Carneiro

Smith

Lusingu

et al. 2006

The American Journal of Tropical Medicine and Hygiene

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Abstract. More than half of all young children and pregnant women are affected by anemia. Although its etiology is multi-factorial, malaria is likely to be a major contributor to chronic anemia in endemic areas. Recent reviews have examined the effect of community-based malaria control interventions on anemia. We analyze how the prevalence of anemia depends on that of Plasmodium falciparum malaria by developing models of the excess risk of anemia caused by malaria at a population level in 24 villages in northeastern Tanzania. In that setting, we estimated that the prevalence of a hemoglobin level < 8 g/dL attributable to malaria was 4.6% in infants, 4.1% in children one year of age, 2.7% in children two years of age, and 3.3% in women of childbearing age. Successful validation of our models in other malaria-endemic settings would enable their use for predicting the impact of malaria control interventions on anemia, and for long-term monitoring and surveillance of malaria.

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Micronutrient malnutrition and the pathogenesis of malarial anemia

Cited by 61 publications

References 105 publications

Renal Responses to a Series of Handball Games Played in Sub-Saharan Environment by Amateur Division 1 of Female Players

Renal Responses to a Series of Handball Games Played in Sub-Saharan Environment by Amateur Division 1 of Female Players

The burden of malaria and malnutrition among children less than 14 years of age in a rural village of Cameroon

Modeling the Relationship Between the Population Prevalence of Plasmodium Falciparum Malaria and Anemia

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