Micronutrient Level Is Negatively Correlated with the Neutrophil-Lymphocyte Ratio in Patients with Severe COVID-19

Zhou, Shengyu; Zhang, Fayan; Chen, Fangfang; Li, Peng; He, Yujie; Wu, Julong; Dong, Liang; Wang, Chunting; Wang, Ximing; Zhang, Wei; Sun, Wenqing; Yin, Lixia; Zhang, Rumin; Zhao, Jintong; Sun, Baoxia

doi:10.1155/2022/6498794

Cited by 8 publications

(9 citation statements)

References 39 publications

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“…The earliest clinical observational study correlating selenium levels with COVID-19 severity was performed at the Qilu Hospital of Shandong University (China) between 27 January and 18 May 2020 [ 53 ]. The authors concluded that “micronutrients should be considered in the treatment of COVID-19, especially in critically ill patients”.…”

Section: Resultsmentioning

confidence: 99%

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Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies

2023

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The purpose of this review is to systematically examine the scientific evidence investigating selenium’s relationship with COVID-19, aiming to support, or refute, the growing hypothesis that supplementation could prevent COVID-19 etiopathogenesis. In fact, immediately after the beginning of the COVID-19 pandemic, several speculative reviews suggested that selenium supplementation in the general population could act as a silver bullet to limit or even prevent the disease. Instead, a deep reading of the scientific reports on selenium and COVID-19 that are available to date supports neither the specific role of selenium in COVID-19 severity, nor the role of its supplementation in the prevention disease onset, nor its etiology.

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Section: Resultsmentioning

confidence: 99%

“…The authors concluded that “micronutrients should be considered in the treatment of COVID-19, especially in critically ill patients”. However, the study lacked controls and involved only 16 patients (8 mild and 8 severe) with different ages and BMIs (statistically different between the two COVID-19 severity groups) [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies

2023

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“…Since the COVID-19 pandemic spread around the world, some studies have been published trying to link Se-deficiency with the disease severity ( Table 3 ). The general interest in Se and COVID-19 has been attributed to its protective role against some viruses and as a modulator of the immune system and inflammatory responses [18] , [19] , [34] , [40] , [196] , [199] , [231] , [232] , [233] , [234] , [235] , [236] , [237] , [238] , [239] , [240] . To date, few clinical studies have indicated a possible causal relation between Se-deficiency and SARS-CoV-2 infection [241] .…”

Section: Se Viral Infection and Viral Replicationmentioning

confidence: 99%

Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review

Golin

Tinkov

Aschner

et al. 2023

Journal of Trace Elements in Medicine and Biology

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“…Selenium studies on the neutrophil-to-lymphocyte ratio (NLR), an index of systemic inflammation [ 61 , 62 , 63 , 64 ], have also indicated interrelationships with Se homeostasis. Selenium and other micronutrients have been negatively correlated with NRL levels in patients with COVID-19 [ 65 ], indicating the protective role of selenium supplementation in severe inflammatory conditions.…”

Section: Introductionmentioning

confidence: 99%

Selenium, Stroke, and Infection: A Threefold Relationship; Where Do We Stand and Where Do We Go?

et al. 2023

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Stroke is currently the second most common cause of death worldwide and a major cause of serious long-term morbidity. Selenium is a trace element with pleotropic effects on human health. Selenium deficiency has been associated with a prothrombotic state and poor immune response, particularly during infection. Our aim was to synthesize current evidence on the tripartite interrelationship between selenium levels, stroke, and infection. Although evidence is contradictory, most studies support the association between lower serum selenium levels and stroke risk and outcomes. Conversely, limited evidence on the role of selenium supplementation in stroke indicates a potentially beneficial effect of selenium. Notably, the relationship between stroke risk and selenium levels is bimodal rather than linear, with higher levels of serum selenium linked to disturbances of glucose metabolism and high blood pressure, morbidities which are, in turn, substrates for stroke. Another such substrate is an infection, albeit forming a bidirectional relationship with both stroke and the consequences of impaired selenium metabolism. Perturbed selenium homeostasis leads to impaired immune fitness and antioxidant capacity, which both favor infection and inflammation; specific pathogens may also contend with the host for transcriptional control of the selenoproteome, adding a feed-forward loop to this described process. Broader consequences of infection such as endothelial dysfunction, hypercoagulation, and emergent cardiac dysfunction both provide stroke substrates and further feed-forward feedback to the consequences of deficient selenium metabolism. In this review, we provide a synthesis and interpretation of these outlined complex interrelationships that link selenium, stroke, and infection and attempt to decipher their potential impact on human health and disease. Selenium and the unique properties of its proteome could provide both biomarkers and treatment options in patients with stroke, infection, or both.

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Micronutrient Level Is Negatively Correlated with the Neutrophil-Lymphocyte Ratio in Patients with Severe COVID-19

Cited by 8 publications

References 39 publications

Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies

Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies

Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review

Selenium, Stroke, and Infection: A Threefold Relationship; Where Do We Stand and Where Do We Go?

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