Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review

Golin, Anieli; Tinkov, Alexey A.; Aschner, Michael; Farina, Marcelo; Rocha, João Batista Teixeira da

doi:10.1016/j.jtemb.2022.127099

Cited by 15 publications

(8 citation statements)

References 264 publications

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“…74,75 However, the nature of the chemical interactions between SELENOK and DHHC6 has not been detailed yet. 76 Scientific efforts made to understand Se's nutritional importance to human health have demonstrated a thin line between Se essentiality and toxicity (Fig. 4).…”

Section: Selenium As a Component Of Selenoproteinsmentioning

confidence: 99%

Organic selenocompounds: are they the panacea for human illnesses?

Rocha

Nogara²,

Pereira³

et al. 2023

New J. Chem.

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Section: Selenium As a Component Of Selenoproteinsmentioning

confidence: 99%

Organic selenocompounds: are they the panacea for human illnesses?

Rocha

Nogara²,

Pereira³

et al. 2023

New J. Chem.

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“…Moreover, as a component of the deiodinases, it has a second important function in thyroid metabolism. In addition, selenium is also important for immune function [ 175 ] and, for example, stimulates interferon production and the activity of natural killer cells [ 176 ]; therefore, selenium deficiency can affect host immunity and could alter virus virulence [ 177 ]. In this regard, there is good evidence that a low selenium status influences the host response to a number of RNA viruses leading to more severe clinical outcomes [ 178 , 179 ].…”

Section: Selected Nutrients and Covid-19mentioning

confidence: 99%

“…In a further report on 50 COVID-19 patients from Korea with and without pneumonia, 42% were selenium deficient [ 187 ]. Other studies also addressed the association between selenium status and COVID-19 outcomes (reviewed in [ 176 ]). In a systematic review with a search up to 27th of June 2021 including 11 studies with 681 COVID-19 patients and 164 healthy individuals, most of the studies showed lower selenium levels in patients compared to controls [ 188 ].…”

Section: Selected Nutrients and Covid-19mentioning

confidence: 99%

“…What should also be considered is that selenium blood levels decrease with age [ 176 ] and that mortality risk in elderly individuals with chronic age-associated diseases is increased by selenium deficiency [ 198 ]. This could have a relevance for worse COVID-19 outcomes in elderly patients with suboptimal selenium status.…”

Section: Selected Nutrients and Covid-19mentioning

confidence: 99%

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The Role of Diet and Specific Nutrients during the COVID-19 Pandemic: What Have We Learned over the Last Three Years?

Rust

Ekmekçioğlu

2023

IJERPH

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Nutrients and diets have an important impact on our immune system and infection risk and a huge number of papers have been published dealing with various aspects of nutrition in relation to SARS-CoV-2 infection risk or COVID-19 severity. This narrative review aims to give an update on this association and tries to summarize some of the most important findings after three years of pandemic. The analysis of major studies and systematic reviews leads to the conclusion that a healthy plant-based diet reduces the risks for SARS-CoV-2 infection and especially COVID-19 severity. Regarding micronutrients, vitamin D is to the fore, but also zinc, vitamin C and, to some extent, selenium may play a role in COVID-19. Furthermore, omega-3-fatty acids with their anti-inflammatory effects also deserve attention. Therefore, a major aim of societal nutritional efforts in future should be to foster a high quality plant-based diet, which not only exerts beneficial effects on the immune system but also reduces the risk for non-communicable diseases such as type 2 diabetes or obesity which are also primary risk factors for worse COVID-19 outcomes. Another aim should be to focus on a good supply of critical immune-effective nutrients, such as vitamin D and zinc.

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“…More interestingly, plasma Se content were generally considered as one of the useful biomarkers of both Se status and dietary intake 6 . Recent studies reported that strong evidence for de cient selenium status has been associated with several diseases risk including cardiovascular diseases (CVD), cancer, and several viral infections such as COVID19, and HIV 7 . Previous studies in chicks have shown that Se de ciency leads to poor growth, and consequently pancreatic atrophy, exudative diathesis, and muscular dystrophy 8 .…”

Section: Introductionmentioning

confidence: 99%

Integrated Transcriptome Profiling Identifies Prognostic Hub genes as Therapeutic Targets of Selenium Deficiency in Chick’s Model: Evidenced by Bioinformatic Analysis

Lingamgunta

Aloor

Gonuguntla

et al. 2022

Preprint

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Selenium deficiency is one of the most prevalent micronutrient deficiencies in the global health issues. Hence, in this investigation, we aimed to explore the key genes and biological pathways associated with selenium deficiency linked with selenium status. Chickens were fed a basal diet, a selenium-deficient diet for 10 weeks. The integrated analysis discovered differential expressed genes between the selenium-deficient and normal samples. Multiple approaches, includes GO analysis (g: Profilers database) and pathway analysis (KEGGs), were employed to functionally annotate the DEGs through R program. The protein-protein interactions (PPI) network, and their visualization, gene cluster, hub genes were identified through the STRING, Cytoscape plugin MCODE, CytoHubba, and CancerGeneNet tool. Our results revealed that administration of selenium-deficient diet markedly reduced plasma selenium concentration. Next, a total of 10,266 DEGs (213 upregulated and 237 downregulated) were identified. GO and KEGGs pathway showed that regulation of cell functions, and cancer pathways. Cytoscape demonstrated that eight modules, ten significant hub genes and CancerGeneNet tool revealed that all hub genes were involved in tumorigenesis pathways. Overall, our investigation offered ten hub genes that could be used as precise diagnostic and prognostic candidate biomarkers of selenium-deficiency might be used as treatment strategy in animal and humans.

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Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review

Cited by 15 publications

References 264 publications

Organic selenocompounds: are they the panacea for human illnesses?

Organic selenocompounds: are they the panacea for human illnesses?

The Role of Diet and Specific Nutrients during the COVID-19 Pandemic: What Have We Learned over the Last Three Years?

Integrated Transcriptome Profiling Identifies Prognostic Hub genes as Therapeutic Targets of Selenium Deficiency in Chick’s Model: Evidenced by Bioinformatic Analysis

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