Micronuclei and chromosome aberrations in bone marrow cells and lymphocytes of humans exposed mainly to petroleum vapors

Högstedt, Benkt; Gullberg, Bo; Mark-Vendel, E.; Mitelman, Felix; Skerfving, Staffan

doi:10.1111/j.1601-5223.1981.tb01751.x

Cited by 50 publications

(7 citation statements)

References 20 publications

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“…Micronuclei and chromosome aberrations in bone marrow cells and lymphocytes of humans exposed mainly to petroleum vapours was earlier reported by Hogstedt et al [82]. In another study, cytogenetic alterations in blood lymphocytes of exposed populations to combustion of biomass-based fuels including kerosene was also reported [83].…”

Section: Genotoxic and Carcinogenic Effectsmentioning

confidence: 80%

Effects and mechanisms of kerosene use-related toxicity

Maiyoh¹,

Njoroge²,

Tuei³

2015

Environmental Toxicology and Pharmacology

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Section: Genotoxic and Carcinogenic Effectsmentioning

confidence: 80%

Effects and mechanisms of kerosene use-related toxicity

Maiyoh¹,

Njoroge²,

Tuei³

2015

Environmental Toxicology and Pharmacology

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“…-When comparing the bone marrow parameters a group of 10 bus drivers (8 males and 2 females), described in detail elsewhere (HOGSTEDT et al 1981), were employed.…”

Section: Controls I Amentioning

confidence: 99%

“…However, the associations are not close. As discussed elsewhere (HOGSTEDT et al 1981) this may have several reasons such as: low precision of the determinations and/or different effect and time sequence of the mutagenic agent on the different parameters studied.…”

Section: Associations Bctween Diffrrent Cytogenetic Parametersmentioning

confidence: 99%

Chromosome aberrations and micronuclei in bone marrow cells and peripheral blood lymphocytes in humans exposed to ethylene oxide

et al. 2008

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Twenty‐eight individuals occupationally exposed to ethylene oxide have been compared with 20 controls regarding cytogenetic effects in peripheral blood lymphocytes and in bone marrow cells. The exposure levels of ethylene oxide were estimated and none of the individuals had, during the last 2.5 years, been exposed to workroom air concentrations exceeding 1 ppm. The exposed persons showed significantly increased levels of chromosome aberrations in lymphocytes (about 50% increase of mean) and of micronuclei in erythroblasts and polychromatic erythrocytes (about 100% and 300% increase of mean, respectively) when compared with controls. However, sister chromatid exchanges and micronuclei in lymphocytes did not show any significant effect of exposure. A significant effect of smoking on micronuclei in erythroblasts and lymphocytes was found. There were several statistically significant, positive correlation coefficients among the different cytogenetic parameters.

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“…The differences may be due either to the culturing conditions or confounding exposures to other metals such as arsen and cadmium, and to polyaromatic hydrocarbons (WANG et al 1978;HOGSTEDT et al 1979HOGSTEDT et al ,1981. In addition, in most of the earlier investigations the statistical methods used have not permitted the separation of the effects of age, smoking habits, and other life-style factors from the occupational exposure.…”

Section: Benkr Hiigstedf Department Of Occupational Medicine Centramentioning

confidence: 99%

Inorganic lead exposure does not effect lymphocyte micronuclei in car radiator repair workers

et al. 2008

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Eighteen individuals exposed to lead in their work with repair and reconditioning of car radiators were investigated regarding blood lead levels and frequencies of lymphocyte micronuclei. The micronuclei werc analyzed in cells with preserved cytoplasm. The lead-exposed group was compared with 12 white-collar workers with no occupational lead exposure. The mean blood lead levels were 2.3 (range 1.50-3.30) and 0.42 (range 0.20-1.05) Kmolil, respectively, with no overlapping of exposed subjects and controls. There was no effect of lead exposure when the influences of age, smoking and drug intake were allowed for in a multivariate analysis. On the other hand, there was a striking effect of age on the frequency of micronuclei. Benkr Hiigstedf, Department of Occupational Medicine, Central Hospital, S-30185 Halmsrad, SwedenThe possible mutagenicicarcinogenic effect of inorganic lead exposure has been discussed for a long time. Inorganic lead does not seem to have any mutagenic effect neither in bacterial test systems, nor in mammalian cells in vitro, with the exception of lead chromate (NESTMAN et al. 1979; DOUGLAS et a1.1980), in which the effect possibly is due to the chromate ion.There are contradictory results of cytogenetic studies in lead-exposed workers (for review and references see MAKI-PAAKKANEN et al. 1981, and. The differences may be due either to the culturing conditions or confounding exposures to other metals such as arsen and cadmium, and to polyaromatic hydrocarbons (WANG et al. 1978;HOGSTEDT et al. 1979HOGSTEDT et al. ,1981. In addition, in most of the earlier investigations the statistical methods used have not permitted the separation of the effects of age, smoking habits, and other life-style factors from the occupational exposure.Micronuclei are formed by a damage either directly to the chromosomes (agentric fragments) or to the spindle apparatus (lagging chromosomes). The micronucleus method applied to cultured lymphocytes with preservation of the cytoplasm has proven to be a rapid and sensitive way of measuring cytogenetic damage in individuals exposed to mutagens such as styrene (HOGSTEDT et al. 1983; Hoc-STEDT 1984). The method has not been used previously in individuals exposed to lead in their occupation.The aim of the present investigation was to study the effect of exposure to fairly pure lead on the frequency of micronuclei in lymphocytes by means of a statistical analysis of the multivariate type to allow for multiple background factors. Material and methodsIndividuals investigated.-The lead-exposed group consisted of eighteen males who had been working with repair and reconditioning of motor vehicle radiators for 2 to 45 (mean 17.8) years. They were 18 to 64 (mean 41) years of age. Eight of them were smokers. Two of them took beta-blocking drugs for hypertension. One had been radiographed within a year before the investigation. One individual had a mild proteinuria since childhood. Otherwise, all were quite healthy and showed no sign of acute or chronic lead intoxication. Their main ex...

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Micronuclei and chromosome aberrations in bone marrow cells and lymphocytes of humans exposed mainly to petroleum vapors

Abstract: Micronuclei and chromosome aberrations in bone marrow cells and lymphocytes of humansexposed mainly to petroleum vapors. -Herediras 94: 179-187. Lund, Sweden.

Cited by 50 publications

References 20 publications

Effects and mechanisms of kerosene use-related toxicity

Effects and mechanisms of kerosene use-related toxicity

Chromosome aberrations and micronuclei in bone marrow cells and peripheral blood lymphocytes in humans exposed to ethylene oxide

Inorganic lead exposure does not effect lymphocyte micronuclei in car radiator repair workers

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