Micronodular basal cell carcinoma. A deceptive histologic subtype with frequent clinically undetected tumor extension

Hendrix, John D.; Parlette, Harry L.

doi:10.1001/archderm.132.3.295

Cited by 49 publications

(42 citation statements)

References 13 publications

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“…34 As mentioned above, lesions may be difficult to remove and so have an increased incidence of recurrence. 32,35 Micronodular BCC manifests tumor nests with roughly the same shape and contour as nodular BCC, but which are nonetheless smaller and widely dispersed in an often asymmetric distribution extending deeper into the dermis and/or subcutis ( Figure 7).…”

Section: Micronodular Bccmentioning

confidence: 99%

“…Retraction spaces are not common and the surrounding stroma shows either a myxoid or collagenized morphology suggesting that these lesions may be an intermediate step between nodular and aggressive growth subtypes. 7,32,34 The micronodular BCC has been reported to have a higher incidence of local recurrence 32,34 and may penetrate more deeply into the reticular dermis and/or subcutis.…”

Section: Micronodular Bccmentioning

confidence: 99%

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Basal cell carcinoma: biology, morphology and clinical implications

2006

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Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising dramatically in incidence in North America, as likely reflects changing habits of the population and a move from more northerly climes to the sunbelt of the Southern and Southwestern United States, the incidence is surely to rise even higher in the future. The last decade has seen significant advances in our understanding of BCC biology and novel approaches to therapy, which hinge upon accurate diagnosis and subclassification by pathologists. The purpose of this review article is to summate the research advances in our understanding of BCC biology and to acquaint pathologists and clinicians to the practical issues in BCC diagnosis and subclassification which flow there from.

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Section: Micronodular Bccmentioning

confidence: 99%

Section: Micronodular Bccmentioning

confidence: 99%

Basal cell carcinoma: biology, morphology and clinical implications

2006

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“…Tampoco la tienen la ilustra también la importancia de la biopsia diferenciación ecrina, sebácea o pilar. Hay profunda y el peligro de la por afeitado carcinomas basocelulares con amplia ,querarebanado en el estudio del carcinoma basocelular tinización en el centro de los lobulillos, de tipo (figura 8).…”

Section: Criterios De Clasificaciónunclassified

“…Extensión, localización y profundidad de invasión: es un criterio general de agresividad de un tumor. La extensión a la grasa, al cartílago y al plano muscular es propia de carcinomas basocelulares de muy larga evolución (figuras 8,10). Aunque se ha dicho que la extensión en profundidad no influye en el pronóstico (2), este dato es de gran utilidad para el dermatólogo tratante.…”

Section: Criterios De Clasificaciónunclassified

El informe histológico del carcinoma basocelular

Rodríguez

Hart

2001

biomedica

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o iin Dcrnialu.og a In-iii~iu luac una. rln C a n~e r o ugia I.n duu ae Derniaiu oga Fac~itao O P Mea cioa Jniveiso30 hac!uila nn Coonloia Bugola D C . CCIUIIIU~ En Colombia, ha sido costumbre hacer el informe microscópico del carcinoma basocelular sin referencia a sus patrones histológicos; es común que sólo diga 'carcinoma basocelular', sin descripción de las características microscópicas. El objetivo de este trabajo es hacer recomendaciones sobre la manera de realizar el informe histológico de este tumor, refiriéndose a sus patrones microscópicos más importantes y a otras características como su dispersión y la invasión perinerural porque tienen importancia en el pronóstico y tratamiento del paciente. Entre los múltiples patrones histológicos que adopta el carcinoma basocelular, los más comunes y de importancia pronóstica son: nodular, superficial, micronodular, trabecular, morfeiforme y fibroepitelial. El carcinoma basocelular micronodular, el trabecular y el morfeiforme son los que más extensión subclínica presentan, los más infiltrantes en profundidad, capaces de dar invasión perineural y de ser los que con mayor frecuencia recidivan, si no se resecan con márgenes suficientes o con cirugía micrográfica de Mohs. Tienen un patrón de crecimiento difuso. El carcinoma basoescamoso es ocasional y tiene capacidad de dar metástasis. El informe histológico del carcinoma basocelular debe incluir una descripción que precise el patrón histológico, el crecimiento disperso o circunscrito y la presencia o ausencia de invasión perineural; debe informar su extensión y localización: si está unido al epitelio, a qué nivel de la dermis penetra y si alcanza la grasa subcutánea o el tejido muscular. El conocimiento de estos datos permite al dermatólogo establecer el pronóstico y hacer el tratamiento más adecuado en cada caso.Palabras clave: carcinoma basocelular, patrones histológicos, informe histopatológico. Histological repon of basal cell carcinomaIn Colombia, the histopathological studies of the basal cell carcinoma are reported without reference to its microscopic characteristics. Herein, recommendations are presented for a more effective histophatological report of this tumor. Reference must be made to the important microscopic patterns as well as to features of dispersion, dissemination and perineural invasion -al1 important forthe prognosis and management of the patient. For prognosis, the most important histological patterns are nodular, superficial, micronodular, trabecular, morpheaform and fibroepithelial. Micronodular, trabecular and morpheaform basal cell carcinomas are those with the highest subclinical extension and are the most deeply infiltrating tumors, able to present perineural invasion and recurrence. They have a diffuse pattern of growth. Basosquamous cell carcinoma is rare and has the potential to metastasize. The histopathological report of basal cell carcinoma should include the description of its histological patterns, its growth type, if it is difíuse or circunscript, and the presence of perineural i...

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“…, Hendrix (1996) e seus colaboradores sugeriram que essas lesões sejam uma variante intermediária entre o subtipo nodular e os subtipos de crescimento agressivo, devido ao fato de serem acompanhadas por proliferação do estroma com características infiltrativa e recidivante.…”

Section: Outros Subtipos Histopatológicosunclassified

Expressão de citocinas, linfócitos, fator de crescimento endotelial vascular (VEGF) e antígeno leucocitário humano G (HLA-G) em carcinoma basocelular

Westin¹

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DEDICATÓRIAA meus pais, Benedito Carlos e Therezinha, principais responsáveis pelo meu caráter e disciplina, que por uma vida de dedicação, amor incondicional e trabalho sempre possibilitaram a seus filhos a oportunidade de realizar seus sonhos e suas conquistas.Aomeu irmão Carlos Francisco e a todos da minha família, que me apoiaram e me estimularam desde que ingressei no doutorado até sua conclusão;A meu esposo, Pedro, companheiro, amigo, amado, pela ajuda, força, estímulo e por me apaziguar nos momentos de ansiedade.A Deus, pela fé, pelo amparo e pela proteção nesses anos da minha vida. À bióloga Cristiane Maria Milanezi pelo apoio no laboratório e pela paciência, dedicação e disposição em contribuir para o trabalho.

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Micronodular basal cell carcinoma. A deceptive histologic subtype with frequent clinically undetected tumor extension

Cited by 49 publications

References 13 publications

Basal cell carcinoma: biology, morphology and clinical implications

Basal cell carcinoma: biology, morphology and clinical implications

El informe histológico del carcinoma basocelular

Expressão de citocinas, linfócitos, fator de crescimento endotelial vascular (VEGF) e antígeno leucocitário humano G (HLA-G) em carcinoma basocelular

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