Micronization and characterization of drug substances by RESS with supercritical CO2

Abstract

A RESS (rapid expansion of supercritical solution) process for the preparation of ultra-fine drug particles with no organic solvent has been developed with supercritical CO 2 . Three drug substances with different solubility in supercritical CO 2 were used, and orifice disks and capillary tubes were adapted as an expansion device. The solubilities of drug substances in supercritical CO 2 and the effects of various operating parameters on the characteristics of the particles prepared by RESS process were experimentally investigated. The solubility of the drug substance in supercritical CO 2 had a major effect on the average diameter of the particle prepared by RESS process, and the particle diameter decreased with the solubility for all the drugs and operating conditions. The particle diameter also decreased with preexpansion temperature and increased with the hole diameter of the orifice nozzle and aspect ratio (L/D) of the capillary tube.

The Effect of Rapid Expansion of Supercritical Solution (RESS) Parameter on Sub-Micron Ibuprofen Particle Forming

“…Therefore large particles could be obtained. Similar results havealso been reportedfor lidocaine by J.-T. Kim [14]. However, when pressure climbed to a certain level, the nucleation process was the deciding factor.…”

Safe Fabrication and Characterization of NC/CL‐20/CnMs Nanoenergetic Composite Materials via Modified Sol‐Gel

“…[19] Up to now, many methods have been utilized to prepare nEMs, such as sol-gel technology, mechanical grinding method, solvent/non-solvent and spraying evaporation and supercritical fluid technology, new type methods including spraying flash evaporation and so on. [20][21][22][23][24][25] Synthesis of nEMs using sol-gel chemistry is performed in solution, possessing more convenience than conventional methods in low-temperature preparation, easy to be controled over the stoichiometry and homogeneity. Therefore, various nEMs have been prepared by sol-gel technology, including (annonium perchlotate) AP/ RDX/SiO 2 , HMX-AP-SiO 2 , (Resorcinol-formaldehyde) RF/RDX, HMX/AP/RF and so on.…”

“…Therefore, nanoenergetic composite materials (nEMs), have aroused considerable investigation interest of researchers, which are consist of a fuel and oxidizer are homogenous at nanometric scale, on account of combining outstanding thermodynamic characteristics of fuel‐oxidizer admixtures (high energy density) and fast release rate of energy [19] . Up to now, many methods have been utilized to prepare nEMs, such as sol‐gel technology, mechanical grinding method, solvent/non‐solvent and spraying evaporation and supercritical fluid technology, new type methods including spraying flash evaporation and so on [20–25] . Synthesis of nEMs using sol‐gel chemistry is performed in solution, possessing more convenience than conventional methods in low‐temperature preparation, easy to be controled over the stoichiometry and homogeneity.…”

Улучшение Растворения Лидокаина Посредством Диспергирования Методом Быстрого Расширения Сверхкритического Раствора

“…Таким образом, на основе анализа имеющейся литературы была разработана УФ-спектрофотометрическая методика установления подлинности, чистоты и количественного определения лидокаина. УФ-метод является наиболее удобным и легким для стандартной процедуры анализа [3,4].…”

“…Таким образом, будет уменьшено время для роста частиц в канале расширения. Кроме того, с увеличением температуры экстракции, согласно работе[3], увеличивается растворимость…”