Microneedle Patches as Drug and Vaccine Delivery Platform

Li, Junwei; Zeng, Mingtao; Huang, Shan; Tong, Chunyi

doi:10.2174/0929867324666170526124053

Cited by 108 publications

(66 citation statements)

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“…(Pérennès et al, 2006;Yoon et al, 2006;Migdadi et al, 2018;Adapted from Waghule et al, 2019). Waghule et al, 2019, Bora et al, 2008, Li et al, 2017, Singh et al, 2016.…”

Section: Resultsmentioning

confidence: 99%

“…Companies in US, Europe and Japan are selling microneedle products, and some of them are listed below. Waghule et al, 2019, Bora et al, 2008, Li et al, 2017, Singh and Yadav, 2016.…”

Section: Approved Productsmentioning

confidence: 99%

“…Coated microneedles are coated with the drug, while polymer microneedles are 'made from polymers that can be dissolving, non-dissolving or hydrogel-forming' (Jepps et al, 2013;Ita, 2015). The specification(s) in which microneedles are fabricated is dependent on the type, geometry and material of the microneedle (Li et al, 2017). The table below details various techniques used for the fabrication of microneedles.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Comprehensive Review on the Potential of Microfabricated Microneedles for Effective Systemic Delivery of Drugs

Adeyemi

2019

Reinvention

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Microneedles are a new technology for percutaneous drug delivery. They are often conveyed in a series of multiple simple microneedles used on the skin to facilitate systemic or topical drug delivery. They are manufactured using various techniques and they could be hollow, solid, coated or polymeric. Although classified as an emerging but expanding field of drug delivery, they are flawed in many ways. This paper will extensively discuss (in the context of skin physiology) the use of microneedles and their feasibility in delivering medication to sites of actions in the body. This paper is a review paper and data were collated from multiple sources including journals and articles. Microneedles show great potential; however, the physiology of the skin poses a great challenge for researches in this field.

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“…(Pérennès et al, 2006;Yoon et al, 2006;Migdadi et al, 2018;Adapted from Waghule et al, 2019). Waghule et al, 2019, Bora et al, 2008, Li et al, 2017, Singh et al, 2016.…”

Section: Resultsmentioning

confidence: 99%

“…Companies in US, Europe and Japan are selling microneedle products, and some of them are listed below. Waghule et al, 2019, Bora et al, 2008, Li et al, 2017, Singh and Yadav, 2016.…”

Section: Approved Productsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Comprehensive Review on the Potential of Microfabricated Microneedles for Effective Systemic Delivery of Drugs

Adeyemi

2019

Reinvention

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“…[] Using lasers, workers can create pores of micrometre diameter with controllable depth. Furthermore, with the development of nanotechnology, the micro‐needle patch, has been shown to be a promising tool for delivering vaccines and drugs,[] and might be amenable for delivering cells into human scalp skin. We are currently testing these new delivery methods.…”

Section: Discussionmentioning

confidence: 99%

Dissociated skin cells regenerate hair follicles in a microwound, “The Punch Assay”

Leng

Wang

Chen

et al. 2018

Experimental Dermatology

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The purpose of this study was to develop a new, easily executed hair follicle regeneration system and assay, which could be further developed for clinical or cosmetic applications. Dissociated epidermal and dermal progenitor cells, isolated either from neonatal C57BL/6 mice or human foetal scalp tissues, were suspended in (10 μL) F12 medium and pipetted into a 1 or 2 mm-diameter punch biopsy wounds on the back skin of immunodeficient mice. At 3 weeks after transplantation, although pigmented mouse hairs could efficiently form at the injection sites with delivery of mouse cells, none hair formed on the host mouse skin at 3 months after delivery of human cells. Under the same conditions, human follicles could be regenerated when the human skin cells were delivered onto a 2 mm size punch created on a reconstituted human skin (hRSK), which previously generated on the back of an immunodeficient mouse, but the efficiency of hair formation was low. We demonstrated that both mouse and human regenerated follicles showed normal histology and differentiation markers; moreover, the cell chasing experiment confirmed that the regenerated hair follicles were formed from transplanted cells. Compared to other current hair reconstituted assays, the Punch Assay is relatively simple and generates normal hair follicles within a smaller wound. We suggest that the punch assay is a better in vivo assay of cell trichogenicity.

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“…Advancement in modern drug delivery methods have unlocked numerous opportunities in the treatment and diagnosis of diseases (Chandel et al 2019;Jain 2014;Li et al 2017;Lim et al 2018;Pandey et al 2019). Ingestion, inhalation, absorption, and intravenous injection are the most common methods of delivering drugs (Jain 2014).…”

Section: Introductionmentioning

confidence: 99%

Parametric study of 3D printed microneedle (MN) holders for interstitial fluid (ISF) extraction

et al. 2020

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The need for novel, minimally invasive diagnostic, prognostic, and therapeutic biomedical devices has garnered increased interest in recent years. Microneedle (MN) technology has stood out as a promising new method for drug delivery, as well as extraction of interstitial fluid (ISF). ISF comprises a large portion of the extracellular fluid in living organisms yet remains inadequately characterized for clinical applications. Current MN research has focused on the fabrication of needles with different materials like silicone, carbon, and metals. However, little effort has been put forth into improving MN holders and patches that can be used with low cost MNs, which could effectively change how MNs are attached to the human body. Here, we describe different 3D-printed MN holders, printed using an MJP Pro 2500 3D printer, and compare the ISF extraction efficiencies in CD Hairless rats. We varied design parameters that may affect the skin-holder interface, such as throat thickness, tip curvature, and throat diameter. MN arrays, with insertion depths of 1500 lm, had extraction efficiencies of 0.44 ± 0.35, 0.85 ± 0.64, 0.32 ± 0.21, or 0.44 ± 0.46 ll/min when designed with flat, concave, convex, or bevel profile geometries, respectively. Our results suggest ISF extraction is influenced by MN holder design parameters and that a concave tip design is optimal for extracting ISF from animals. The future direction of this research aims to enable a paradigm in MN design that maximizes its efficiency and engineering performance in terms of volume, pressure, and wearability, thereby automatizing usage and reducing patient intervention to ultimately benefit remote telemedicine.

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Microneedle Patches as Drug and Vaccine Delivery Platform

Cited by 108 publications

References 0 publications

A Comprehensive Review on the Potential of Microfabricated Microneedles for Effective Systemic Delivery of Drugs

A Comprehensive Review on the Potential of Microfabricated Microneedles for Effective Systemic Delivery of Drugs

Dissociated skin cells regenerate hair follicles in a microwound, “The Punch Assay”

Parametric study of 3D printed microneedle (MN) holders for interstitial fluid (ISF) extraction

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