Microneedle-based devices for point-of-care infectious disease diagnostics

Dixon, Rachael V.; Skaria, Eldhose; Lau, Wing Man; Manning, Philip; Birch‐Machin, Mark A.; Moghimi, S. Moein; Ng, Keng Wooi

doi:10.1016/j.apsb.2021.02.010

Cited by 39 publications

(36 citation statements)

References 173 publications

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“…[ 68 ] In terms of technical innovation, integrating microneedle to capillary blood collection devices has been developed to streamline sample collection in a minimally invasive manner. [ 69 , 70 ] Recently, microneedle patches have been used as an alternative in ISF collection. [ 71 , 72 , 73 ] A microneedle patch can be integrated seamlessly with POC devices (LOAD, 3D paper‐based devices) offering the simple, integrated, and potential sample collection format.…”

Section: Smartphone‐based Point‐of‐care Testing For Virus Detectionmentioning

confidence: 99%

Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

et al. 2022

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Infectious virus outbreaks pose a significant challenge to public healthcare systems. Early and accurate virus diagnosis is critical to prevent the spread of the virus, especially when no specific vaccine or effective medicine is available. In clinics, the most commonly used viral detection methods are molecular techniques that involve the measurement of nucleic acids or proteins biomarkers. However, most clinic‐based methods require complex infrastructure and expensive equipment, which are not suitable for low‐resource settings. Over the past years, smartphone‐based point‐of‐care testing (POCT) has rapidly emerged as a potential alternative to laboratory‐based clinical diagnosis. This review summarizes the latest development of virus detection. First, laboratory‐based and POCT‐based viral diagnostic techniques are compared, both of which rely on immunosensing and nucleic acid detection. Then, various smartphone‐based POCT diagnostic techniques, including optical biosensors, electrochemical biosensors, and other types of biosensors are discussed. Moreover, this review covers the development of smartphone‐based POCT diagnostics for various viruses including COVID‐19, Ebola, influenza, Zika, HIV, et al. Finally, the prospects and challenges of smartphone‐based POCT diagnostics are discussed. It is believed that this review will aid researchers better understand the current challenges and prospects for achieving the ultimate goal of containing disease‐causing viruses worldwide.

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Section: Smartphone‐based Point‐of‐care Testing For Virus Detectionmentioning

confidence: 99%

Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

et al. 2022

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“…These include microneedles for biofluid extraction, microneedle sensors and analyte-capturing microneedles, or combinations thereof. These technologies are in their early stages of development for infectious disease diagnostics, and there is a vast scope for further development [ 182 ]. Just this year, wearable device-based detection of COVID-19 was proposed [ 183 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Biosensors as Nano-Analytical Tools for COVID-19 Detection

Pradhan

Lahare

Sinha

et al. 2021

Sensors

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Selective, sensitive and affordable techniques to detect disease and underlying health issues have been developed recently. Biosensors as nanoanalytical tools have taken a front seat in this context. Nanotechnology-enabled progress in the health sector has aided in disease and pandemic management at a very early stage efficiently. This report reflects the state-of-the-art of nanobiosensor-based virus detection technology in terms of their detection methods, targets, limits of detection, range, sensitivity, assay time, etc. The article effectively summarizes the challenges with traditional technologies and newly emerging biosensors, including the nanotechnology-based detection kit for COVID-19; optically enhanced technology; and electrochemical, smart and wearable enabled nanobiosensors. The less explored but crucial piezoelectric nanobiosensor and the reverse transcription-loop mediated isothermal amplification (RT-LAMP)-based biosensor are also discussed here. The article could be of significance to researchers and doctors dedicated to developing potent, versatile biosensors for the rapid identification of COVID-19. This kind of report is needed for selecting suitable treatments and to avert epidemics.

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“…[29][30][31] Moreover, the needle will not touch the nerve endings and blood vessels, so it also can reduce the patient's pain and enhance the patient's compliance. [32][33][34][35][36][37] Compared with traditional transdermal delivery strategies, MNs technology can not only deliver high molecular weight drugs, but also increase the drug per- meability. The comparison of the characteristics for different administration routes is listed in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Wang

Jiang

Aharodnikau

et al. 2022

Macromol. Rapid Commun.

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In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.

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Microneedle-based devices for point-of-care infectious disease diagnostics

Cited by 39 publications

References 173 publications

Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

Virus Detection: From State‐of‐the‐Art Laboratories to Smartphone‐Based Point‐of‐Care Testing

Biosensors as Nano-Analytical Tools for COVID-19 Detection

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

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