Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid

Kashaninejad, Navid; Munaz, Ahmed; Moghadas, Hajar; Yadav, Sharda; Umer, Muhammad; Nguyen, Nam‐Trung

doi:10.3390/chemosensors9040083

Cited by 52 publications

(56 citation statements)

References 186 publications

(338 reference statements)

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“…For example, a dedicated apical module with integrated microneedles could be developed to study the effect of these devices on the delivery of pharmacologically active ingredients. Microneedle devices are increasing in popularity due to their potential for transdermal delivery, disease treatment and diagnosis [ 78 , 79 ]. Finally, a user-friendly interface is also an important consideration when designing a SoC device.…”

Section: Key Requirements For the Development Of Skin-on-a-chip Devicesmentioning

confidence: 99%

Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models

Zoio

Oliva

2022

Pharmaceutics

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The increased demand for physiologically relevant in vitro human skin models for testing pharmaceutical drugs has led to significant advancements in skin engineering. One of the most promising approaches is the use of in vitro microfluidic systems to generate advanced skin models, commonly known as skin-on-a-chip (SoC) devices. These devices allow the simulation of key mechanical, functional and structural features of the human skin, better mimicking the native microenvironment. Importantly, contrary to conventional cell culture techniques, SoC devices can perfuse the skin tissue, either by the inclusion of perfusable lumens or by the use of microfluidic channels acting as engineered vasculature. Moreover, integrating sensors on the SoC device allows real-time, non-destructive monitoring of skin function and the effect of topically and systemically applied drugs. In this Review, the major challenges and key prerequisites for the creation of physiologically relevant SoC devices for drug testing are considered. Technical (e.g., SoC fabrication and sensor integration) and biological (e.g., cell sourcing and scaffold materials) aspects are discussed. Recent advancements in SoC devices are here presented, and their main achievements and drawbacks are compared and discussed. Finally, this review highlights the current challenges that need to be overcome for the clinical translation of SoC devices.

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Section: Key Requirements For the Development Of Skin-on-a-chip Devicesmentioning

confidence: 99%

Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models

Zoio

Oliva

2022

Pharmaceutics

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“…Therefore, even similar cell types (like breast tumor cells at early or late cancer stages) may differ in DEP characteristics [ 43 , 74 ], and it can affect the separation efficiency in these procedures. Many scholars are currently working in this field to tackle this problem [ 130 ].…”

Section: Technical and Biological Challenges Of Dep Approachesmentioning

confidence: 99%

Signal-Based Methods in Dielectrophoresis for Cell and Particle Separation

et al. 2022

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Separation and detection of cells and particles in a suspension are essential for various applications, including biomedical investigations and clinical diagnostics. Microfluidics realizes the miniaturization of analytical devices by controlling the motion of a small volume of fluids in microchannels and microchambers. Accordingly, microfluidic devices have been widely used in particle/cell manipulation processes. Different microfluidic methods for particle separation include dielectrophoretic, magnetic, optical, acoustic, hydrodynamic, and chemical techniques. Dielectrophoresis (DEP) is a method for manipulating polarizable particles’ trajectories in non-uniform electric fields using unique dielectric characteristics. It provides several advantages for dealing with neutral bioparticles owing to its sensitivity, selectivity, and noninvasive nature. This review provides a detailed study on the signal-based DEP methods that use the applied signal parameters, including frequency, amplitude, phase, and shape for cell/particle separation and manipulation. Rather than employing complex channels or time-consuming fabrication procedures, these methods realize sorting and detecting the cells/particles by modifying the signal parameters while using a relatively simple device. In addition, these methods can significantly impact clinical diagnostics by making low-cost and rapid separation possible. We conclude the review by discussing the technical and biological challenges of DEP techniques and providing future perspectives in this field.

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“…MAE can penetrate the cuticle of human skin and eliminate the effect of cuticle on impedance ( Ren et al, 2020b ). Meanwhile, MNs do not require skin preparation for puncture and result in minimal skin trauma ( Kashaninejad et al, 2021 ). It has been shown that MAE has a lower and more stable EII than commonly used dry electrodes.…”

Section: Microneedle-based Device For Bio-signal Recordingmentioning

confidence: 99%

Microneedle-Based Device for Biological Analysis

Zada

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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The collection and analysis of biological samples are an effective means of disease diagnosis and treatment. Blood sampling is a traditional approach in biological analysis. However, the blood sampling approach inevitably relies on invasive techniques and is usually performed by a professional. The microneedle (MN)-based devices have gained increasing attention due to their noninvasive manner compared to the traditional blood-based analysis method. In the present review, we introduce the materials for fabrication of MNs. We categorize MN-based devices based on four classes: MNs for transdermal sampling, biomarker capture, detecting or monitoring analytes, and bio-signal recording. Their design strategies and corresponding application are highlighted and discussed in detail. Finally, future perspectives of MN-based devices are discussed.

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Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid

Cited by 52 publications

References 186 publications

Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models

Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models

Signal-Based Methods in Dielectrophoresis for Cell and Particle Separation

Microneedle-Based Device for Biological Analysis

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