Micrognathia after radiation therapy for childhood facial tumors

Kaste, Sue C.; Hopkins, Kenneth P.

doi:10.1016/s0030-4220(06)80115-5

Cited by 22 publications

(17 citation statements)

References 20 publications

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“…The inhibitory effect of radiation on osteogenesis commonly manifests as hypoplasia of bones among survivors of childhood cancer (45, 48, 50, 51, 55, 66), reported especially in flat bones (21, 33, 42, 45–47, 50, 66–69). In a study of 89 survivors of various childhood cancers treated at a median age of 3.8 years and followed for an average of 10.8 years, Crooks et al .…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

Gawade¹,

Hudson²,

Kaste³

et al. 2015

CPR

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Survivors of childhood cancer are at risk for treatment-related musculoskeletal late effects. Early detection and orthopedic intervention can help ameliorate musculoskeletal late effects and prevent subsequent complications. This systematic review summarizes the literature describing associations between cancer, its treatment, and musculoskeletal late effects. We searched PubMed and Web of Science for English language articles published between January 1970 and December 2012. The search was limited to investigations with at least 15 participants and conducted at least 2 years after completion of therapy for childhood, adolescent, or young adult cancer. Some late skeletal effects, including low bone mineral density, osteonecrosis, slipped capital femoral epiphyses, oncogenic rickets, and hormone-related growth disturbances have been previously reviewed and were excluded, as were outcomes following amputation and limb-salvage procedures. Of 2347 references identified, 30 met inclusion criteria and were retained. An additional 54 studies that met inclusion criteria were found in reference lists of retained studies. Of 84 studies, 60 focused on associations between radiotherapy, six between chemotherapy, and 18 between surgery and musculoskeletal late effects. We found that younger age, higher radiation dosage, and asymmetric or partial bone radiation volume influences the effects of radiation on the musculoskeletal system. Methotrexate and vincristine are associated with long-term muscular strength and flexibility deficits. Laminectomy and chest wall resection are associated with spinal malalignment, and enucleation is associated with orbital deformities among survivors. Radiotherapy, chemotherapy, and surgery are associated with musculoskeletal late effects independently and additively. Associations are additionally influenced by host and treatment characteristics.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of Selected Musculoskeletal Late Effects in Survivors of Childhood Cancer

Gawade¹,

Hudson²,

Kaste³

et al. 2015

CPR

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“…In addition, hypodontia and root-stunting (which rarely occur in the general population but affected deciduous and permanent dentition of 17% of our patients) may preclude adequate orthodontic anchorage [31,32]. These deficiencies may lead to long-term functional morbidity [1,2,7], thereby placing patients with these dental abnormalities at increased risk for periodontal disease and subsequent tooth loss.…”

Section: Discussionmentioning

confidence: 99%

“…Aggressive treatment regimens may have a dramatic impact on the health and quality of life of long-term survivors of cancer [1][2][3][4][5][6][7][8][9][10]. In addition, late adverse effects of therapy are becoming increasingly prevalent due to improved survival rates among infants and children; these treatment-associated sequelae include dental abnormalities.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, late adverse effects of therapy are becoming increasingly prevalent due to improved survival rates among infants and children; these treatment-associated sequelae include dental abnormalities. Chemotherapy [3,6,[11][12][13] and radiation therapy [1][2][3][13][14][15][16] have been implicated in various dental abnormalities, the type and severity of which reflect the timing of the insult during dental development [3,8,14]. The types and frequencies of dental sequelae in children treated at a young age for cancer have not been described extensively.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dental abnormalities in children treated for neuroblastoma

Kaste

Hopkins

Bowman

et al. 1998

Med. Pediatr. Oncol.

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“…Direct irradiation to the developing facial bones often results in bony hypoplasia and soft tissue deficits (6,8,9,16,19,21,(23)(24)(25)(26)(27)(28)31,39). The extent and severity of the defects is related to the radiation type (orthovoltage versus megavoltage), the age of the patient, and the radiation dose (23,24,27).…”

Section: Discussionmentioning

confidence: 99%