Dental abnormalities in children treated for neuroblastoma

Kaste, Sue C.; Hopkins, Kenneth P.; Bowman, Laura C.; Santana, Víctor M.

doi:10.1002/(sici)1096-911x(199801)30:1<22::aid-mpo8>3.0.co;2-2

Cited by 63 publications

(75 citation statements)

References 21 publications

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“…Dietary factors, such as a highcarbohydrate diet, and difficulty with oral hygiene because of mucositis may also contribute to the risk of caries. 14,21 A decrease in the elasticity of the perioral tissues has also been Table 1 Demographics and dental maturation of 259 patients who underwent dental radiography prior to BMT Dental abnormalities before pediatric BMT MD Vaughan et al noted in patients after BMT, which may increase the risk of dental complications by reducing access to the oral cavity. 2,22 Berkowitz 23 noted histopathologic changes in the minor salivary glands and resultant xerostomia in all patients in his study who developed chronic GVHD.…”

Section: Discussionsupporting

confidence: 79%

“…Nasam, 13 Kaste et al [14][15][16] observed hypodontia, microdontia, enamel hypoplasia, root stunting, taurodontia, over-retention of primary teeth, and an increased caries index in survivors of childhood cancer. Impaired root development reduces the growth of alveolar bone, which adversely affects the subsequent vertical development of the mandible and the lower one-third of the face.…”

Section: Discussionmentioning

confidence: 99%

“…Radiation of 1000 cGy or more may result in reduced salivary flow and a resultant altered pH balance in the oral cavity, causing a shift in oral flora and an increase in caries. 2,14 Only 10 of our patients had a diagnosis of head and neck tumors and thus, the effect of local irradiation should not have been a causative factor in this cohort as a whole. Dietary factors, such as a highcarbohydrate diet, and difficulty with oral hygiene because of mucositis may also contribute to the risk of caries.…”

Section: Discussionmentioning

confidence: 99%

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Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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Summary:The purpose of our study was to describe the types and frequencies of altered dental development in pediatric patients preparing for bone marrow transplantation (BMT). Retrospective review of the medical records and panoramic radiographs of all patients who underwent BMT at St Jude Children's Research Hospital between 1990 and 2000 for whom pre-BMT dental examination and panoramic radiography records were available. All patients were treated on institutional protocols. We recorded patient demographics and radiographic evidence of microdontia, hypodontia, taurodontia, root stunting, caries, enamel pearls, and pulpal calcifications. The 259 patients identified (150 male and 109 female) had a median age of 12.82 years (range, 3.18-25.93 years) at the time of BMT. In total, 203 were Caucasian, 38 were African-American, and 18 were of other races. In all, 150 (57.9%) had abnormal dentition. The most common dental abnormalities were caries (n ¼ 84), pulpal calcifications (n ¼ 34), and dental extractions (n ¼ 33). Developmental abnormalities occurred less frequently: taurodontia (n ¼ 8), hypodontia (n ¼ 10), microdontia (n ¼ 11), and root stunting (n ¼ 11). Dental abnormalities are prevalent in children undergoing BMT. Pre-transplant oral hygiene and dental examination should be standard care in order to minimize potential sites of infection.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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“…These findings were consistent with previous studies. [5][6][7][8][9][10][11][12][13] Dental development is a complex and prolonged process. The development of permanent teeth is initiated between 5 months in utero and 9 months postnatally (excluding third molars), and the initial calcification process (excluding third molars) occurs between 3 months and 3 years of age and continues until coronal development is complete around 8 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…1 Well-established long-term effects of antineoplastic treatment include dental disturbances such as microdontia, 2 atypical root formation, 3,4 and tooth aplasia. [5][6][7][8][9][10][11][12][13][14] Other effects include hyposalivation, [15][16][17] dental immaturity and disturbances in dental eruption, as well as trismus and osteoradionecrosis. 18 However, it is difficult to attribute these effects to any single agent or treatment modality, as multimodal therapy is employed in almost all childhood cancers.…”

mentioning

confidence: 99%

Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy

Hsieh

Hibbert

Shaw

et al. 2010

Cancer

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BACKGROUND:The aim of this study was to examine the effect of antineoplastic therapy on dental development and saliva function in recipients of childhood antineoplastic therapy. METHODS: Patients attending the long-term follow-up clinic at Children's Hospital at Westmead, NSW, Australia, were included if they had received treatment prior to 16 years of age and were in remission for more than 5 years. A dental examination and saliva test were performed for each participant. Holtta's Defect Index (HDI) was used to assess tooth aplasia, microdontia, and root-crown ratio on an orthopantomogram (OPG). Multivariable-adjusted regression analyses were used to estimate the association of patient characteristics and treatment modalities with dental outcomes. RESULTS: One hundred six participants (61% male) were recruited (response rate ¼ 88%). The mean HDI score was 24.7 AE 17.8. A cumulative dose of cyclophosphamide >7500 mg/m 2 increased the HDI score by 13.06 (P ¼ .01). Recipients of cyclophosphamide also had significantly increased odds of exhibiting very low saliva flow (<0.7 mL/min) (odds ratio ¼ 12.43; 95% confidence interval, 2.08-74.35; P ¼ .006). CONCLUSIONS: Children and adolescents who received high doses of cyclophosphamide were at increased risk of dental disturbances. Cyclophosphamide recipients were also at greater risk of exhibiting very low saliva flow. This study applied the HDI to patients receiving all forms of antineoplastic treatment and highlights the dose-dependent relation between cumulative dose of cyclophosphamide and dental disturbances.

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References

2012

Pathology of the Hard Dental Tissues

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Dental abnormalities in children treated for neuroblastoma

Cited by 63 publications

References 21 publications

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy

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