Microglial responses to inflammatory challenge in adult rats altered by developmental exposure to polychlorinated biphenyls in a sex-specific manner

Walker, Katherine A.; Rhodes, Simone T.; Liberman, Deborah A.; Gore, Andrea C.; Bell, Margaret R.

doi:10.1016/j.neuro.2024.07.009

NeuroToxicology

2024

DOI: 10.1016/j.neuro.2024.07.009

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Microglial responses to inflammatory challenge in adult rats altered by developmental exposure to polychlorinated biphenyls in a sex-specific manner

Katherine A. Walker,

Simone T. Rhodes,

Deborah A. Liberman

et al.

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Microglia Signatures: A Cause or Consequence of Microglia-Related Brain Disorders?

Mirarchi,

Albi,

Arcuri

2024

IJMS

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Microglia signatures refer to distinct gene expression profiles or patterns of gene activity that are characteristic of microglia. Advances in gene expression profiling techniques, such as single-cell RNA sequencing, have allowed us to study microglia at a more detailed level and identify unique gene expression patterns that are associated, but not always, with different functional states of these cells. Microglial signatures depend on the developmental stage, brain region, and specific pathological conditions. By studying these signatures, it has been possible to gain insights into the underlying mechanisms of microglial activation and begin to develop targeted therapies to modulate microglia-mediated immune responses in the CNS. Historically, the first two signatures coincide with M1 pro-inflammatory and M2 anti-inflammatory phenotypes. The first one includes upregulation of genes such as CD86, TNF-α, IL-1β, and iNOS, while the second one may involve genes like CD206, Arg1, Chil3, and TGF-β. However, it has long been known that many and more specific phenotypes exist between M1 and M2, likely with corresponding signatures. Here, we discuss specific microglial signatures and their association, if any, with neurodegenerative pathologies and other brain disorders.

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Microglia Signatures: A Cause or Consequence of Microglia-Related Brain Disorders?

Mirarchi,

Albi,

Arcuri

2024

IJMS

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Microglial responses to inflammatory challenge in adult rats altered by developmental exposure to polychlorinated biphenyls in a sex-specific manner

Cited by 1 publication

References 225 publications

Microglia Signatures: A Cause or Consequence of Microglia-Related Brain Disorders?

Microglia Signatures: A Cause or Consequence of Microglia-Related Brain Disorders?

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