2018
DOI: 10.1016/j.nbd.2018.01.002
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Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis

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Cited by 29 publications
(28 citation statements)
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“…Microglial activation is the major pathogenic contribution in the development of EAE through the release of proinflammatory cytokines. 39 Hence, we examined the activation of microglia in the spinal cord using IHC staining. As shown in Table 2, a notable infiltration of IL-6 + , TNF + , and Iba-1 + cells was observed in the spinal cords harvested from EAE mice, which was significantly reduced by the NHNK treatment.…”
Section: Nhnk Attenuated the Infiltration Of Activated Microglial Intmentioning
confidence: 99%
“…Microglial activation is the major pathogenic contribution in the development of EAE through the release of proinflammatory cytokines. 39 Hence, we examined the activation of microglia in the spinal cord using IHC staining. As shown in Table 2, a notable infiltration of IL-6 + , TNF + , and Iba-1 + cells was observed in the spinal cords harvested from EAE mice, which was significantly reduced by the NHNK treatment.…”
Section: Nhnk Attenuated the Infiltration Of Activated Microglial Intmentioning
confidence: 99%
“…To investigate the role of NO and its intracellular cascade in neuronal cytolysis, the NO synthesis were added into the culture medium of neurons at 100pg/ml, 100 pg/ml, 80 ng/ml and 20 ng/ml respectively. The concentrations of inhibitors, activators and recombinant cytokines were selected based on previous studies [23,30].…”
Section: Inhibitors Activators and Recombinant Cytokinesmentioning
confidence: 99%
“…To investigate the mechanisms of cytolysis induced by conditioned media from microglias treated with OMS+NB IgG, we focus on the NO/sGC/PKG pathway, for its role in neuronal death is well documented [21][22][23] and the production of NO from microglias was raised by OMS+NB IgG (Fig. 2a2-d2).…”
Section: The Effects Of Inhibitors or Activators Of No/sgc/pkg Pathwamentioning
confidence: 99%
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