2009
DOI: 10.1002/glia.20874
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Microglia processes block the spread of damage in the brain and require functional chloride channels

Abstract: Microglia cells exhibit two forms of motility, constant movement of filopodia probing surrounding brain tissue, and outgrowth of larger processes in response to nearby damage. The mechanisms and functions of filopodia sensing and process outgrowth are not well characterized but are likely critical for normal immune function in the brain. Using two photon laser scanning microscopy we investigated microglia process outgrowth in response to damage, and explored the relationship between process outgrowth and filop… Show more

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Cited by 176 publications
(173 citation statements)
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“…We also observed the identical staining pattern for the DSD-1 antibody (Fig. 2 H, I,M ), which binds to a uniquely sulfated CS-GAG and is only poorly detected by CS-56 and WFALectin (Ito et al, 2005). The absence of DSD-1 immunostaining from the invasive tumors ruled out the possibility that the invasive tumors may have switched to a CS-GAG expression profile unrecognized by our labeling methods.…”
Section: Self-contained Focused Lesions But Not Diffusely Invasive supporting
confidence: 63%
See 1 more Smart Citation
“…We also observed the identical staining pattern for the DSD-1 antibody (Fig. 2 H, I,M ), which binds to a uniquely sulfated CS-GAG and is only poorly detected by CS-56 and WFALectin (Ito et al, 2005). The absence of DSD-1 immunostaining from the invasive tumors ruled out the possibility that the invasive tumors may have switched to a CS-GAG expression profile unrecognized by our labeling methods.…”
Section: Self-contained Focused Lesions But Not Diffusely Invasive supporting
confidence: 63%
“…4D) are highly reminiscent of injury-associated microglia. Because these microglia are know to play a critical role in cordoning off and inhibiting further spread of damage away from sites of CNS injury, we speculate that these tumor-adjacent microglia may likewise serve a noninfiltrative function (Nimmerjahn et al, 2005;Lalancette-Hébert et al, 2007;Rolls et al, 2008;Hines et al, 2009). Overall, our findings placed in context with the literature suggest that distinct microglial states, modulated through the ECM, may in turn result in pro-or anti-invasive contributions to the tumor microenvironment.…”
Section: Discussionmentioning
confidence: 99%
“…In the situation of trauma, the astrocytes are the first to sense injury, and the activation of microglia is triggered by astrocytic ATP release. Lack of Cx43 hemichannels causes reduced leakage of ATP and thus inhibits the activation of microglia [25][26][27] . The release of TNF-α and IL-1β from LPS-activated microglia targets astrocytes mainly through Cx43 hemichannels [28,29] .…”
Section: Resultsmentioning
confidence: 99%
“…Therefore, delayed and diminished extensions of microglial processes in Kindlin3-knockin mice are likely to be a consequence of diminished post-ligand-binding events, including Y397 FAK phosphorylation. Defects in early microglial response to injury were shown to increase lesion volume and promote its spreading into the surrounding tissues (51). In addition, microglial response to injury was shown to contribute to the timely restoration of blood-brain barrier (52).…”
Section: Discussionmentioning
confidence: 99%