2017
DOI: 10.1172/jci.insight.93002
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Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages

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Cited by 27 publications
(26 citation statements)
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References 60 publications
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“…These results confirm our previous understanding that even in the absence of a stimulus, microglia are constantly surveying their microenvironment through the continuous extension and retraction of ramified projections (27,28). We did not observe any instances of microglial cell body migration, in line with a previous finding of limited movement of microglial soma (42). Conversely, we found that infiltrating BMDMs are minimally branched and highly migratory.…”
Section: Discussionsupporting
confidence: 92%
“…These results confirm our previous understanding that even in the absence of a stimulus, microglia are constantly surveying their microenvironment through the continuous extension and retraction of ramified projections (27,28). We did not observe any instances of microglial cell body migration, in line with a previous finding of limited movement of microglial soma (42). Conversely, we found that infiltrating BMDMs are minimally branched and highly migratory.…”
Section: Discussionsupporting
confidence: 92%
“…Thus, kindlin‐2 is the only isoform endogenously expressed in neurons and plays a role in normal axonal growth. Kindlin‐3 is predominantly expressed by cells of the immune system (Malinin et al ., ; Moser et al ., ; Feigelson et al ., ; Cohen et al ., ; Moretti et al ., ) and recently has been discovered in microglia of the brain (Meller et al ., ).…”
Section: Integrin Activators Promote Sensory Axonal Regeneration In Tmentioning
confidence: 97%
“…K3KI knock-in mice were generated as previously described (Xu et al, 2014;Meller et al, 2017). Bones were collected from male and female K3KI mice and wild-type (WT) littermates at 9 weeks of age under a Cleveland Clinic IACUC approved animal protocol (n=14-17).…”
Section: Animal Studiesmentioning
confidence: 99%
“…The K3KI mutated Kindlin-3 knock-in mice contain a double mutation (Q 597 W 598 /AA) designed to disrupt the integrin recognition region resulting in diminished integrin binding (Xu et al, 2014(Xu et al, , 2015. Integrin expression in these mice remains equal to WT mice (Meller et al, 2017). Growth plates in 9-week old K3KI and WT mice were stained for markers of cartilage maturation.…”
Section: Mutated Kindlin-3 Mice Display Disrupted Growth Plate Chondrmentioning
confidence: 99%