Microglandular Adenosis, Apocrine Adenosis, and Tubular Carcinoma of the Breast

Eusebi, Vincenzo; Foschini, Maria Pia; Betts, Christine M.; Gherardi, Giorgio; Millis, Rosemary R.; Bussolati, Gianni; Azzopardi, J. G.

doi:10.1097/00000478-199302000-00001

Cited by 80 publications

(57 citation statements)

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“…Microglandular Adenosis (MGA), thought to be a benign proliferation of the breast, is characterized by its lack of a myoepithelial cell layer [11][12][13][14]. It is an infiltrative lesion that has since been associated with an increased risk for the development of in-situ and invasive breast carcinoma [1,[11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…It is an infiltrative lesion that has since been associated with an increased risk for the development of in-situ and invasive breast carcinoma [1,[11][12][13][14]. Recently, absence of a myoepithelial cell layer has also been observed in some metaplastic apocrine glands [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…MGA is regarded by some as a pre-malignant process. Some cases of MGA evolve through MGA with atypia to invasive carcinoma [1,12]. Recent cytogenetic evidence of clonality in MGA suggests that it is a neoplastic, probably low-grade malignant, disorder rather than a hyperplasia [14].…”

Section: Discussionmentioning

confidence: 99%

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Hypersecretory Thyroid-like Adenosis of the Breast: A Distinct Benign Entity Devoid of Myoepithelial Cells

Munday¹

2015

J Clin Exp Pathol

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Most infiltrative epithelial proliferations of the breast lacking a myoepithelial cell layer are malignant. The notable exception is Microglandular Adenosis (MGA). Lack of myoepithelial cells has also been noted occasionally in metaplastic apocrine glands. Here, we present a previously undescribed breast lesion that we have termed "Hypersecretory Thyroid-Like Adenosis" (HTLA). HTLA consists of multiple dilated glands of varying sizes preserving a lobulated architecture. The glands are lined by a single layer of bland cuboidal or columnar cells. Some nuclei have cleared chromatin, some exhibit grooves and others contain pseudo-inclusions reminiscent of papillary carcinoma of thyroid. Dense eosinophilic secretions, positive for PAS-Diastase and resembling thyroidal colloid, are present in many of the lumens. A thick basement membrane is present around each gland. There are no Myoepithelial (ME) cells present on H&E examination, immunohistochemistry or ultrastructural study. The immunohistochemical stain for S-100 protein shows weak focal nuclear and cytoplasmic staining of the minority of the luminal cells (<20% of cells). The lesion is ER negative. HTLA has some features similar to, but is overall distinctly different from MGA. In particular, the preserved lobular architecture, macroacinar structures, distinctive nuclear features, and lack of diffusely strong immunostaining for S-100 protein are features unlike MGA. This lesion was an incidental finding in a partial mastectomy performed for invasive ductal carcinoma but showed no spatial relationship, morphological or immunohistochemical similarities to the breast carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hypersecretory Thyroid-like Adenosis of the Breast: A Distinct Benign Entity Devoid of Myoepithelial Cells

Munday¹

2015

J Clin Exp Pathol

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“…Microglandular adenosis typically ranges from 1 to 4 cm in size. 2,7,9,11 There are no specific imaging findings for MGA; however, the mammogram result is often abnormal (ill-defined mass or density) and may be suspicious for malignancy. 1,2,8,9,12 Microcalcifications may be evident on mammography in some cases.…”

Section: Myoepithelial-negative Small Glandular Proliferations-mga Anmentioning

confidence: 99%

“…Myoepithelial cells are absent in MGA, and therefore show no immunoreactivity with these markers (Figure 2, D). Basement membrane investing the glands of MGA can be highlighted with immunostains, such as collagen type IV or laminin (Figure 2, D, inset), 11,14 or with histochemical stains, such as reticulin or periodic acid-Schiff. Microglandular adenosis characteristically shows strong immunohistochemical staining for S100 protein 3,5,10,14-16 and lacks immunohistochemical staining for ER, progesterone receptor (PR), and HER2.…”

Section: Myoepithelial-negative Small Glandular Proliferations-mga Anmentioning

confidence: 99%

Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry: A Review Focusing on the Differential Diagnosis and Interpretative Pitfalls

Ginter

Shin²,

D’Alfonso³

2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Small glandular proliferations of the breast encompass a variety of benign, atypical, and malignant lesions that show some overlapping morphologic features. Myoepithelial stains are frequently used in the workup of these lesions in order to rule out or establish a diagnosis of invasive carcinoma. Some benign lesions show absent or diminished myoepithelial staining, and may represent an interpretative pitfall, particularly in small core biopsy samples. Objective.—To review small glandular proliferations of the breast that show absent or diminished staining with myoepithelial immunohistochemical markers. Data Sources.—The study comprised a review of published literature and clinical case material. Conclusions.—The interpretation of myoepithelial stains in small glandular proliferations of the breast can, on some occasions, represent a challenge in diagnosing these lesions. Recognition of the key histopathologic features and immunohistochemical staining patterns of the entities in the differential diagnosis is crucial in their workup.

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Aspiration biopsy cytology of tubular carcinoma of the breast

Tos¹,

Giustina²,

Martin³

et al. 1994

Diagnostic Cytopathology

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Tubular carcinoma represents a rare, well-differentiated type of breast malignancy, characterized by relatively unaggressive clinical behavior. Cytologic diagnosis of this subgroup of tumors is considered difficult as cell population usually presents in tightly cohesive clusters and shows minimal atypia. Cytomorphologic features of 15 examples of histologically proven pure tubular carcinomas of the breast are herein reported. If a constellation of morphologic criteria is critically evaluated, tubular carcinoma may be diagnosed on cytologic specimens. Aspiration biopsy cytology represents an optimal diagnostic tool in the preoperative diagnosis of breast masses. Its application to the detection of this special type of breast carcinoma permits better planning of therapeutic procedures.

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Microglandular Adenosis, Apocrine Adenosis, and Tubular Carcinoma of the Breast

Cited by 80 publications

References 0 publications

Hypersecretory Thyroid-like Adenosis of the Breast: A Distinct Benign Entity Devoid of Myoepithelial Cells

Hypersecretory Thyroid-like Adenosis of the Breast: A Distinct Benign Entity Devoid of Myoepithelial Cells

Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry: A Review Focusing on the Differential Diagnosis and Interpretative Pitfalls

Aspiration biopsy cytology of tubular carcinoma of the breast

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