Aspiration biopsy cytology of tubular carcinoma of the breast

Tos, Angelo Paolo Dei; Giustina, Dino Della; Martin, Vallì De; Libera, Duilio Della; Bittesini, L

doi:10.1002/dc.2840110208

Cited by 13 publications

(2 citation statements)

References 11 publications

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“…TCs are more frequently hypercellular and the abnormal tubules are more abundant and diffuse and have a more rigid outline or acutely angled configuration. Discohesive cells are also more abundant [82,83,84,85,86]. Single cells with intact cytoplasm could mimic lobular carcinoma.…”

Section: Proliferative Breast Lesionsmentioning

confidence: 99%

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Indeterminate and Erroneous Fine-Needle Aspirates of Breast with Focus on the ‘True Gray Zone': A Review

2013

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Objective: To review our experience and the literature on inconclusive/erroneous fine-needle aspirates (FNAs) of breast with the focus on the ‘true gray zone'. To describe the cytology, differential diagnosis, pitfalls and limitations of common and rare lesions. Study Design: We conducted a literature search focusing on breast FNAs with statistical data of C3 and C4 categories including false-positive and false-negative cases. Similar data from 2003 to 2009 was obtained from our institution. Results: C3 and C4 categories account for 3-17% of breast FNAs. Contributing factors are technical difficulties, inexperienced pathologists interpreting FNAs of breast and overlap of cytologic features of certain benign and malignant conditions; this last, ‘true gray zone' accounts for 2% of cases. Fibroadenoma, proliferative breast lesions, gynecomastia, infiltrating and in situ low-grade adenocarcinomas and tubular, cribriform, lobular and mucinous carcinomas are the most common problematic lesions. Granular cell tumor, adenomyoepithelioma, pregnancy-related lesions, fat necrosis, inflammatory and radiation changes, adenoid cystic carcinoma, spindle-cell lesions and Phyllodes tumor are less common. Conclusion: Inconclusive/erroneous FNAs of breast due to the ‘true gray zone' are rare. Most are due to the overlapping cytologic features of some benign and malignant conditions. Practical features that may help arrive at the correct diagnoses are elucidated.

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Section: Proliferative Breast Lesionsmentioning

confidence: 99%

“…The diagnosis of TC by FNAC is difficult with less than 50% of cases classified as C5 [82,83,84,85,86]. The characteristic findings include tubular structures, noteworthy dissociation, paucity of myoepithelium and cellular atypia [86].…”

Section: Mammary Carcinoma and Its Variantsmentioning

confidence: 99%

Indeterminate and Erroneous Fine-Needle Aspirates of Breast with Focus on the ‘True Gray Zone': A Review

2013

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Cytologic features of 22 radial scar/complex sclerosing lesions of the breast, three of which associated with carcinoma: Clinical, mammographic, and histologic correlation

Bonzanini

Gilioli²,

Brancato

et al. 1997

Diagn. Cytopathol.

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Cytologic features of tubular adenocarcinoma of the breast by aspiration biopsy

Cangiarella¹,

Waisman²,

Shapiro³

et al. 2001

Diagnostic Cytopathology

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Tubular adenocarcinoma is an invasive mammary adenocarcinoma associated with an excellent prognosis and a low incidence of axillary metastases. However, identification of tubular adenocarcinoma by fine-needle aspiration (FNA) biopsy has proven difficult. One hundred five patients with documented "pure" tubular adenocarcinoma were diagnosed at Tisch Hospital from August of 1992 to December of 1998. Twenty-one of these patients had an FNA before excision. We reviewed the smears of these cases and compared them with cases of fibroadenoma and fibrocystic change to identify criteria for diagnosis. Moderately to highly cellular smears with angular cellular clusters with sharp borders and oval cells outlining these clusters, dispersed single cells with minimal atypia, and the absence or paucity of dispersed bare oval nuclei in the background were features that suggest a diagnosis of tubular adenocarcinoma in our study. Attention to these features in combination with appropriate mammographic findings should preclude a false-negative diagnosis in the majority of cases of tubular adenocarcinoma diagnosed by aspiration biopsy. We point to the presence of the peripheral perpendicular cells in the characteristic tubular arrays as an important clue to the diagnosis of tubular adenocarcinoma.

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Aspiration biopsy cytology of tubular carcinoma of the breast

Cited by 13 publications

References 11 publications

Indeterminate and Erroneous Fine-Needle Aspirates of Breast with Focus on the ‘True Gray Zone': A Review

Indeterminate and Erroneous Fine-Needle Aspirates of Breast with Focus on the ‘True Gray Zone': A Review

Cytologic features of 22 radial scar/complex sclerosing lesions of the breast, three of which associated with carcinoma: Clinical, mammographic, and histologic correlation

Cytologic features of tubular adenocarcinoma of the breast by aspiration biopsy

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