Microfluidics with ultrasound-driven bubbles

Marmottant, Philippe; Raven, Jan-Paul; Gardeniers, Han; Bomer, Johan G.; Hilgenfeldt, Sascha

doi:10.1017/s0022112006002746

Cited by 93 publications

(101 citation statements)

References 26 publications

(35 reference statements)

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“…However, recently there has been a growing trend in harnessing this byproduct for a variety of novel applications (Rife et al 2000;Tsai and Lin 2002;Hilgenfeldt 2003, 2004;Dijkink et al 2006;Marmottant et al 2006;Hettiarachchi et al 2007; Kao et al 2007; Tho et al 2007;Xu and Attinger 2007;Chung and Cho 2008;Ahmed et al 2009a, b;Chung and Cho 2009;Tovar and Lee 2009). The first practical use of trapped air bubbles in a microfluidic device utilized acoustic energy to rapidly mix two fluids within a chamber (Liu et al 2002) for the increase of DNA hybridization (Liu et al 2003a, b).…”

Section: Introductionmentioning

confidence: 99%

“…The combination of acoustic energy and trapped air bubbles within these microsystems allowed for the generation of localized microstreaming which produced rapid mixing characteristics within a platform that is predominately laminar. The use of this phenomenon was integrated into a cell trapping and lysing system (Marmottant and Hilgenfeldt 2003) and thereafter harnessed for particle transport (Marmottant and Hilgenfeldt 2004;Marmottant et al 2006). Particle transport was achieved through the use of asymmetrical flow caused by obstructions near the liquid-air interface of trapped air bubbles within etched surface cavities (Marmottant et al 2006).…”

Section: Introductionmentioning

confidence: 99%

“…The use of this phenomenon was integrated into a cell trapping and lysing system (Marmottant and Hilgenfeldt 2003) and thereafter harnessed for particle transport (Marmottant and Hilgenfeldt 2004;Marmottant et al 2006). Particle transport was achieved through the use of asymmetrical flow caused by obstructions near the liquid-air interface of trapped air bubbles within etched surface cavities (Marmottant et al 2006). The use of acoustic microstreaming was further studied to determine how interface oscillations are related to voltage and frequency input (Xu and Attinger 2007).…”

Section: Introductionmentioning

confidence: 99%

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Lateral air cavities for microfluidic pumping with the use of acoustic energy

Tovar

Patel

Lee

2011

Microfluid Nanofluid

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An acoustically activated micropump is fabricated and demonstrated using a single step lithography process and an off-chip acoustic energy source. Using angled lateral cavities with trapped air bubbles, acoustic energy is used to oscillate the liquid-air interface to create a fluidic driving force. The angled lateral cavity design allows for fluid rectification from the first-order pulsatile flow of the oscillating bubbles. The fluid rectification is achieved through the asymmetrical flow produced by the oscillating interface generating fluid flow away from the lateral cavity interface. Simulation and experimental results are used to develop a pumping mechanism that is capable of driving fluid at pressures of 350 Pa. This pumping system is then integrated into a stand-alone battery operated system to drive fluid from one chip to another.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lateral air cavities for microfluidic pumping with the use of acoustic energy

Tovar

Patel

Lee

2011

Microfluid Nanofluid

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“…It also minimizes unwanted bubble destruction, which is beneficial for both imaging and therapeutic applications such as drug delivery and gene therapy where bubbles are used as encapsulation vehicles and premature destruction would be highly undesirable (Harvey et al 2002). Similarly, increasing the strength of flow phenomena such as microstreaming around the bubble could assist cell permeabilization for drug/ gene delivery (Marmottant & Hilgenfeldt 2003) and could also be useful in other applications where these effects are exploited, for example microfluidic devices (Marmottant et al 2006).…”

Section: Resultsmentioning

confidence: 99%

Increasing the nonlinear character of microbubble oscillations at low acoustic pressures

Stride

Pancholi

Edirisinghe

et al. 2008

J. R. Soc. Interface.

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The nonlinear response of gas bubbles to acoustic excitation is an important phenomenon in both the biomedical and engineering sciences. In medical ultrasound imaging, for example, microbubbles are used as contrast agents on account of their ability to scatter ultrasound nonlinearly. Increasing the degree of nonlinearity, however, normally requires an increase in the amplitude of excitation, which may also result in violent behaviour such as inertial cavitation and bubble fragmentation. These effects may be highly undesirable, particularly in biomedical applications, and the aim of this work was to investigate alternative means of enhancing nonlinear behaviour. In this preliminary report, it is shown through theoretical simulation and experimental verification that depositing nanoparticles on the surface of a bubble increases the nonlinear character of its response significantly at low excitation amplitudes. This is due to the fact that close packing of the nanoparticles restricts bubble compression.Keywords: bubbles; nonlinear dynamics; microbubbles; nanoparticles; ultrasound THEORETICAL PREDICTIONIn order to predict the effect of particles on the dynamic behaviour of a bubble excited by an acoustic field, a modified Rayleigh-Plesset equation was derived, whereby the radial oscillations of a bubble coated with a surfactant layer containing particles of a given size and concentration are described bywhere R is the instantaneous radius of the bubble; R 0 is its initial value; p 0 is the ambient pressure; s 0 is the initial interfacial tension; G 0 is the initial concentration of the surfactant on the bubble surface; x and K are constants for the surfactant; _ R and € R are the velocity and acceleration of the bubble wall, respectively; r L is the density and m L the viscosity of the surrounding fluid; p A is the pressure due to the applied sound field; p G is the pressure of the gas inside the bubble; R x is the limiting bubble radius beneath which the surface buckles; and B and h s0 are again constants for the individual surfactant. Further details of the treatment of the surfactant coating may be found in Stride (2008). The original equation for an uncoated bubble is given by Plesset & Prosperetti (1977).The effect of the particles is described by the quantity G that is defined aswhere f p is the fractional surface area coverage that defines the limiting radius R lim at which the particles would be expected to reach their square packing density in two dimensions and beyond which the bubble's resistance to further compression would be expected to increase by a factor determined by the compressibility of the particles. This is represented by the quantity X, which is estimated from the ratio of the effective shear moduli of the particles and the surfactant coating. The pressure p rad radiated by the bubble at a distance r from its centre may be predicted using Vokurka (1990) ð1:3Þ Equations (1.1) and (1.3) were solved numerically using purpose-written code in MATLAB R2006b (The Mathworks, Inc., Natick, MA, USA) im...

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“…In this work an extended study on an ultrasonic microreactor described before (Fernandez Rivas et al, 2010) is presented. The working principle of that sonoreactor is based on the ability of small predefined crevices (pits etched in silicon substrate surface (Bremond et al, 2006b,a;Marmottant et al, 2006;Borkent et al, 2009)) to stabilize small gas nuclei. When the ultrasound is turned on, a characteristic microbubble cloud appears, that would not be present in the absence of pits.…”

Section: Introductionmentioning

confidence: 99%

Sonoluminescence and sonochemiluminescence from a microreactor

Rivas

Ashokkumar

Leong

et al. 2012

Ultrasonics Sonochemistry

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Micromachined pits on a substrate can be used to nucleate and stabilize microbubbles in a liquid exposed to an ultrasonic field. Under suitable conditions, the collapse of these bubbles can result in light emission (sonoluminescence, SL). Hydroxyl radicals (OH . ) generated during bubble collapse can react with luminol to produce light (sonochemiluminescence, SCL). SL and SCL intensities were recorded for several regimes related to the pressure amplitude (low and high acoustic power levels) at a given ultrasonic frequency (200 kHz) for pure water, and aqueous luminol and propanol solutions. Various arrangements of pits were studied, with the number of pits ranging from no pits (comparable to a classic ultrasound reactor), to three-pits. Where there was more than one pit present, in the high pressure regime the ejected microbubbles combined into linear (two-pits) or triangular (three-pits) bubble clouds (streamers). In all situations where a pit was present on the substrate, the SL was intensified and increased with the number of pits at both low and high power levels. For imaging SL emitting regions, Argon (Ar) saturated water was used under similar conditions. SL emission from aqueous propanol solution (50 mM) provided evidence of transient bubble cavitation. Solutions containing 0.1 mM luminol were also used to demonstrate the radical production by attaining the SCL emission regions.

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Microfluidics with ultrasound-driven bubbles

Cited by 93 publications

References 26 publications

Lateral air cavities for microfluidic pumping with the use of acoustic energy

Lateral air cavities for microfluidic pumping with the use of acoustic energy

Increasing the nonlinear character of microbubble oscillations at low acoustic pressures

Sonoluminescence and sonochemiluminescence from a microreactor

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