Microfluidics-based hairpin resonator biosensor for biological cell detection

Liu, Chia Feng; Wang, Min Haw; Jang, Ling Sheng

doi:10.1016/j.snb.2018.01.234

Cited by 35 publications

(23 citation statements)

References 28 publications

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“…Thus, increasing the volume, increases N′ and consequenctly ϵ′. Hence there is an opportunity to utilize this phenomenon to measure the concentration of biomolecules by observing the changes in permittivity, as done in glucose [5], heparin [7] and melanoma [8] biosensors.…”

Section: Introductionmentioning

confidence: 99%

EM-Wave Biosensors: A Review of RF, Microwave, mm-Wave and Optical Sensing

Mehrotra

Chatterjee

Sen

2019

Sensors

152

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This article presents a broad review on optical, radio-frequency (RF), microwave (MW), millimeter wave (mmW) and terahertz (THz) biosensors. Biomatter-wave interaction modalities are considered over a wide range of frequencies and applications such as detection of cancer biomarkers, biotin, neurotransmitters and heart rate are presented in detail. By treating biological tissue as a dielectric substance, having a unique dielectric signature, it can be characterized by frequency dependent parameters such as permittivity and conductivity. By observing the unique permittivity spectrum, cancerous cells can be distinguished from healthy ones or by measuring the changes in permittivity, concentration of medically relevant biomolecules such as glucose, neurotransmitters, vitamins and proteins, ailments and abnormalities can be detected. In case of optical biosensors, any change in permittivity is transduced to a change in optical properties such as photoluminescence, interference pattern, reflection intensity and reflection angle through techniques like quantum dots, interferometry, surface enhanced raman scattering or surface plasmon resonance. Conversely, in case of RF, MW, mmW and THz biosensors, capacitive sensing is most commonly employed where changes in permittivity are reflected as changes in capacitance, through components like interdigitated electrodes, resonators and microstrip structures. In this paper, interactions of EM waves with biomatter are considered, with an emphasis on a clear demarcation of various modalities, their underlying principles and applications.

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Section: Introductionmentioning

confidence: 99%

EM-Wave Biosensors: A Review of RF, Microwave, mm-Wave and Optical Sensing

Mehrotra

Chatterjee

Sen

2019

Sensors

152

View full text Add to dashboard Cite

show abstract

“…With regard to optical biosensors, it needs a long settling time for detection and is highly susceptible to change the test results for ambient light [33][34][35][36][37][38][39][40][41]. Recently, a biosensor based on radio frequency (RF) techniques has attracted enormous attention and is regarded as a promising and competitive candidate for implementing third-generation glucose biosensors [42][43][44][45][46][47]. Compared to other types of biosensors, RF biosensors offer the following advantages: first, they are different from the electrochemical biosensors, which are subject to the constraints of the use environment and performance degradation with service time.…”

Section: Introductionmentioning

confidence: 99%

Reusable, Non-Invasive, and Ultrafast Radio Frequency Biosensor Based on Optimized Integrated Passive Device Fabrication Process for Quantitative Detection of Glucose Levels

Yao

Yue

et al. 2020

Sensors

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The increase in the number of people suffering diabetes has been the driving force behind the development of glucose sensors to overcome the current testing shortcomings. In this work, a reusable, non-invasive and ultrafast radio frequency biosensor based on optimized integrated passive device fabrication process for quantitative detection of glucose level was developed. With the aid of the novel biosensor design with hammer-shaped capacitors for carrying out detection, both the resonance frequency and magnitude of reflection coefficient can be applied to map the different glucose levels. Meanwhile, the corresponding fabrication process was developed, providing an approach for achieving quantitative detection and a structure without metal-insulator-metal type capacitor that realizes low cost and high reliability. To enhance the sensitivity of biosensor, a 3-min dry etching treatment based on chlorine/argon-based plasma was implemented for realizing hydrophilicity of capacitor surface to ensure that the biosensor can be touched rapidly with glucose. Based on above implementation, a non-invasive biosensor having an ultrafast response time of superior to 0.85 s, ultralow LOD of 8.01 mg/dL and excellent reusability verified through five sets of measurements are realized. The proposed approaches are not limited the development of a stable and accurate platform for the detection of glucose levels but also presents a scheme toward the detection of glucose levels in human serum.

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“…The integration of microfluidic structures with microwave resonators brings very attractive characteristics to microwave sensors and enables high‐throughput analysis in constant volumes in the range of nanoliters to milliliters . This aspect allows inspection of live cells in a closed microfluidic chip, while reducing the risk of environmental contamination . The conjunction of microwave electromagnetics and microfluidic technology is starting to be utilized in cancer‐cell identification, and bacterial and viral contamination monitoring .…”

Section: Introductionmentioning

confidence: 99%

“…11,12 This aspect allows inspection of live cells in a closed microfluidic chip, while reducing the risk of environmental contamination. 13,14 The conjunction of microwave electromagnetics and microfluidic technology is starting to be utilized in cancer-cell identification, 15 and bacterial and viral contamination monitoring. [16][17][18] A coplanar waveguide integrated with a microfluidic structure has been reported to distinguish live from heat-killed E. coli cells with OD 600 of 3.0 (2.4 × 10 9 cells/mL) at a wide range of frequency (0.5-20 GHz).…”

Section: Introductionmentioning

confidence: 99%

Real‐time monitoring of Escherichia coli concentration with planar microwave resonator sensor

Mohammadi

Narang

Mohammadi

et al. 2019

Micro & Optical Tech Letters

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This work presents a microfluidic chip integrated with a microwave resonator sensor for real‐time and contactless detection of Escherichia coli bacteria concentration. The design is fabricated on a Rogers RT/duroid 5880 high‐frequency substrate and operates at 2.5 ∼ 2.6 GHz, in the ISM band, with an initial quality factor of 112. The presented sensor demonstrates resonant amplitude sensitivity of −0.01231 dB/log(OD600) and resonant frequency sensitivity of −56 kHz/log(OD600) for E. coli concentration in a constant pH of 7.5. To facilitate the analysis of the proposed structure, a lumped equivalent circuit is presented and simulated in ADS and proven accurate by both HFSS microwave simulations and experimental results.

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Microfluidics-based hairpin resonator biosensor for biological cell detection

Cited by 35 publications

References 28 publications

EM-Wave Biosensors: A Review of RF, Microwave, mm-Wave and Optical Sensing

EM-Wave Biosensors: A Review of RF, Microwave, mm-Wave and Optical Sensing

Reusable, Non-Invasive, and Ultrafast Radio Frequency Biosensor Based on Optimized Integrated Passive Device Fabrication Process for Quantitative Detection of Glucose Levels

Real‐time monitoring of Escherichia coli concentration with planar microwave resonator sensor

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