Microfluidic synthesis of quantum dots and their applications in bio-sensing and bio-imaging

Cheng, Yu; Ling, Si Da; Geng, Yuhao; Wang, Yundong; Xu, Jianhong

doi:10.1039/d0na00933d

Cited by 33 publications

(15 citation statements)

References 111 publications

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“…Quantum dots (QDs) are 5-20 nm sized semiconductor nanocrystals with their excitons confined in all three dimensions. [193] Due to this discrete energy level, QDs exhibit outstanding electronic and optical performances such as high fluorescence brightness, long fluorescence lifetime and good stability, etc. As a result, QDs have found various applications in the biomedical fields such as bioimaging, biosensing, and drug delivery, [194,195] and their laboratory and industrial production has also been arousing increasingly more interests during the past decades.…”

Section: Quantum Dotsmentioning

confidence: 99%

Microfluidic Nanoparticles for Drug Delivery

Liu

Yang

Hui

et al. 2022

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Nanoparticles (NPs) have attracted tremendous interest in drug delivery in the past decades. Microfluidics offers a promising strategy for making NPs for drug delivery due to its capability in precisely controlling NP properties. The recent success of mRNA vaccines using microfluidics represents a big milestone for microfluidic NPs for pharmaceutical applications, and its rapid scaling up demonstrates the feasibility of using microfluidics for industrial‐scale manufacturing. This article provides a critical review of recent progress in microfluidic NPs for drug delivery. First, the synthesis of organic NPs using microfluidics focusing on typical microfluidic methods and their applications in making popular and clinically relevant NPs, such as liposomes, lipid NPs, and polymer NPs, as well as their synthesis mechanisms are summarized. Then, the microfluidic synthesis of several representative inorganic NPs (e.g., silica, metal, metal oxide, and quantum dots), and hybrid NPs is discussed. Lastly, the applications of microfluidic NPs for various drug delivery applications are presented.

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Section: Quantum Dotsmentioning

confidence: 99%

Microfluidic Nanoparticles for Drug Delivery

Liu

Yang

Hui

et al. 2022

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“…Functionalized QDs can be used to observe and calculate the concentration and distribution of biomarkers in organisms. In addition, QDs can be used as cell sensors to detect cancer cells through fluorescence and electrochemical signals ( Cheng et al, 2021 ).…”

Section: The Application Of Etl In Bioengineeringmentioning

confidence: 99%

Advances of Commercial and Biological Materials for Electron Transport Layers in Biological Applications

Yin

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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Electron transport layer (ETL), one of the important layers for high-performing perovskite solar cells (PSCs), also has great potential in bioengineering applications. It could be used for biological sensors, biological imaging, and biomedical treatments with high resolution or efficiency. Seldom research focused on the development of biological material for ETL and their application in biological uses. This review will introduce commercial and biological materials used in ETL to help readers understand the working mechanism of ETL. And the ways to prepare ETL at low temperatures will also be introduced to improve the performance of ETL. Then this review summarizes the latest research on material doping, material modification, and bilayer ETL structures to improve the electronic transmission capacity of ETLs. Finally, the application of ETLs in bioengineering will be also shown to demonstrate that ETLs and their used material have a high potential for biological applications.

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“…The synthesis of TGA-OsTe 2 QD was achieved via bottom-up approach by following the method illustrated by Chang et al [19], with slight modifications. Osmium tetrachloride and tellurium powder were used as Os and Te sources, respectively.…”

Section: Synthesis Of Tga Capped Oste 2 Qdmentioning

confidence: 99%

Biocompatible Osmium Telluride-Polypyrrole Nanocomposite Material: Application in Prostate Specific Antigen Immunosensing

2021

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Prostate cancer is a dominant global threat to society. It affects nearly 4000 men in South Africa annually, making it the second most threatening cancerous disease after lung cancer. A potential serological biomarker to monitor early diagnosis of prostate cancer is prostate specific antigen (PSA). We used the PSA biomarker in our work to develop an extremely sensitive electrochemical immunosensor to achieve low detection limits. The fabrication steps followed with the combination of thioglycolic acid capped osmium telluride quantum dots (TGA-OsTe2QD)-polypyrrole (PPy) nanocomposite and prostate specific antigen modified on a glassy carbon electrode. The UV-Vis signatures of TGA-OsTe2QD-PPy showed an absorption band at 262 nm which is attributed to the PPy and TGA-OsTe2QD composite. This band corresponds to the energy band gap of 4.4 and 5.4 eV. The CV responses of BSA|Ab|TGA-OsTe2QD|PPy|GCE modified electrode to prostate specific antigen (PSA) was studied within a range of 0–16 ng/mL PSA that was linear, herein referred to as liner range (LR), which produced a limit of detection (LOD) value of 0.36 ng/mL PSA. The values of the immunosensor’s calibration parameters (LR and LOD) make them suitable for real sample application, due to their coverage of the PSA concentration range (0–14 ng/mL) that is of clinical importance.

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Microfluidic synthesis of quantum dots and their applications in bio-sensing and bio-imaging

Abstract: Bio-sensing and bio-imaging of organisms or molecules can provide key information for the study of physiological processes or the diagnosis of diseases. Quantum dots (QDs) stand out to be promising...

Cited by 33 publications

References 111 publications

Microfluidic Nanoparticles for Drug Delivery

Microfluidic Nanoparticles for Drug Delivery

Advances of Commercial and Biological Materials for Electron Transport Layers in Biological Applications

Biocompatible Osmium Telluride-Polypyrrole Nanocomposite Material: Application in Prostate Specific Antigen Immunosensing

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