Microfluidic synthesis of manganese-alginate nanogels with self-supplying H2O2 capability for synergistic chemo/chemodynamic therapy and boosting anticancer immunity

Su, Miao; Zhu, Yueqiang; Chen, Junbin; Zhang, Beibei; Sun, Chunyang; Chen, Meiwan; Yang, Xianzhu

doi:10.1016/j.cej.2022.134926

Cited by 37 publications

(17 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…UCNP@GA-Fe(III) Fe 3+ (CDT) Fe 3+ (MRI) [268,270] GBD-Fe Fe 3+ (CDT) Fe 3+ (MRI) [269] DOX@Mn-Alg Mn 2+ (CDT) Mn 2+ (MRI) [271,272] pCo 3 O 4 Co 3 O 4 (PTT) Co 2+ (MRI) [273] ipGdIO-Dox Fe 2+ (Ferroptosis) Fe 2+ , Gd 3+ (MRI) [274] CuS-NiS 2 CuS-NiS 2 (PTT/ PDT) Cu 2+ , Ni 2+ (MRI) [275] MPDA-WS 2 @ MnO 2 WS 2 (PTT) W 4+ (CT), Mn 2+ (MRI) [276] FeWO X -PEG-RGD FeWO X (PTT/PDT/ CDT) W 4+ (CT), Fe 3+ (MRI) [241] PEI-Bi 2 Se 3 Bi 2 Se 3 (PTT) Bi 3+ (CT) [277] Bi-Ag@PVP Bi-Ag (PTT) Bi 3+ (CT) [278] Bi 2 S 3 @Ce6-CeO 2 Bi 2 S 3 (PTT) Bi 3+ (CT) [279] CdTeSe/ZnS (QDs) CdTeSe/ZnS (PTT) CdTeSe/ZnS QDs (FL) [280] CCM@AT Ag 2 S (PTT) Ag 2 S QDs (FL) [281] Besides, there is an urgent need for research on mechanisms in point of the new approaches, such as ferroptosis, calcicoptosis, and especially cuproptosis, which makes it possible to achieve broader anti-cancer applications. Ultimately, controlled clinical trials are mandatory to define better the limits and effectiveness of this promising novel diagnostic and therapeutic tool.…”

Section: Referencesmentioning

confidence: 99%

New anti-cancer explorations based on metal ions

et al. 2022

J Nanobiotechnol

View full text Add to dashboard Cite

Due to the urgent demand for more anti-cancer methods, the new applications of metal ions in cancer have attracted increasing attention. Especially the three kinds of the new mode of cell death, including ferroptosis, calcicoptosis, and cuproptosis, are of great concern. Meanwhile, many metal ions have been found to induce cell death through different approaches, such as interfering with osmotic pressure, triggering biocatalysis, activating immune pathways, and generating the prooxidant effect. Therefore, varieties of new strategies based on the above approaches have been studied and applied for anti-cancer applications. Moreover, many contrast agents based on metal ions have gradually become the core components of the bioimaging technologies, such as MRI, CT, and fluorescence imaging, which exhibit guiding significance for cancer diagnosis. Besides, the new nano-theranostic platforms based on metal ions have experimentally shown efficient response to endogenous and exogenous stimuli, which realizes simultaneous cancer therapy and diagnosis through a more controlled nano-system. However, most metal-based agents have still been in the early stages, and controlled clinical trials are necessary to confirm or not the current expectations. This article will focus on these new explorations based on metal ions, hoping to provide some theoretical support for more anti-cancer ideas.

show abstract

Section: Referencesmentioning

confidence: 99%

New anti-cancer explorations based on metal ions

et al. 2022

J Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…Chemodynamic therapy is based on the conversion of endogenous H 2 O 2 into highly toxic hydroxyl radicals ( ⋅ OH), causing the elimination of cancer cells [ 55 ]; in other words, it destroys cancer cells via the conversion of H 2 O 2 or O 2 into reactive oxygen species (ROS). However, the slow release of catalyst ions and deficient levels of H 2 O 2 along with the limited tumor tissue penetration of the light source can severely restrict the performance of this tactic.…”

Section: Alginate-based Micro- and Nanosystems For Cancer Therapeuticsmentioning

confidence: 99%

“…However, the slow release of catalyst ions and deficient levels of H 2 O 2 along with the limited tumor tissue penetration of the light source can severely restrict the performance of this tactic. To overcome these challenges, doxorubicin-loaded manganese–alginate nanogels were designed with self-supplying H 2 O 2 potentials via the application of a microfluidic chip ( Figure 5 ) [ 55 ]. These nanogels could rapidly release the anticancer drug in a pH-responsive behavior after internalization into tumor cells, revealing synergetic antitumor activities with no noticeable systemic toxicity.…”

Section: Alginate-based Micro- and Nanosystems For Cancer Therapeuticsmentioning

confidence: 99%

“…This chemodynamic therapy could stimulate the dendritic cell maturation and enhance the tumor infiltration of CD8 + T cells. The application of these nanogels with Mn 2+ -chelating and H 2 O 2 self-supplying capabilities can be considered an attractive strategy for synergetic chemodynamic therapy with potentials for cancer immunotherapy [ 55 ].…”

Section: Alginate-based Micro- and Nanosystems For Cancer Therapeuticsmentioning

confidence: 99%

See 1 more Smart Citation

Alginate-Based Micro- and Nanosystems for Targeted Cancer Therapy

Iravani

Varma

2022

Marine Drugs

View full text Add to dashboard Cite

Alginates have been widely explored due to their salient advantages of hydrophilicity, biocompatibility, mucoadhesive features, bioavailability, environmentally-benign properties, and cost-effectiveness. They are applied for designing micro- and nanosystems for controlled and targeted drug delivery and cancer therapy as alginate biopolymers find usage in encapsulating anticancer drugs to improve their bioavailability, sustained release, pharmacokinetics, and bio-clearance. Notably, these nanomaterials can be applied for photothermal, photodynamic, and chemodynamic therapy of cancers/tumors. Future explorations ought to be conducted to find novel alginate-based (nano)systems for targeted cancer therapy using advanced drug delivery techniques with benefits of non-invasiveness, patient compliance, and convenience of drug administration. Thus, some critical parameters such as mucosal permeability, stability in the gastrointestinal tract environment, and drug solubility ought to be considered. In addition, the comprehensive clinical translational studies along with the optimization of synthesis techniques still need to be addressed. Herein, we present an overview of the current state of knowledge and recent developments pertaining to the applications of alginate-based micro- and nanosystems for targeted cancer therapy based on controlled drug delivery, photothermal therapy, and chemodynamic/photodynamic therapy approaches, focusing on important challenges and future directions.

show abstract

“…Considering the limited level of endogenous H 2 O 2 in cancer cells, various strategies to stimulate the generation of endogenous H 2 O 2 have been introduced. − Doxorubicin (DOX), with broad-spectrum antineoplastic activities, has been extensively used in chemotherapy (CT) of cancers by suppressing the progression of topoisomerase II . DOX can activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and catalyze the reaction of NADPH and oxygen (O 2 ) to produce superoxide radicals (O 2 •– ), which can induce the diagnosis of cancer cells through oxidative damage of cellular components .…”

Section: Introductionmentioning

confidence: 99%

Single-Site Fe-N-C Atom Based Carbon Nanotubes for Mutually Promoted and Synergistic Oncotherapy

Han

Wei

Liu

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

A carbon nanotube (CNT) supported single-site Fe-N-C catalyst (CNTs/Fe-N-C) exhibited attractive properties in peroxidase (POD)-like activity and photothermal effect. Herein, we designed a therapeutic platform by wrapping doxorubicin (DOX) in mesoporous CNTs/Fe-N-C with the cell membrane (CM) of breast cancer. The ultimate nanoagent (CNTs/Fe-N-C/DOX/CM) exhibited high antitumor activity on account of its efficient catalytic ability, increased drug release rates, and significant photothermal effect. Due to the POD-like activity, CNTs/Fe-N-C could effectively catalyze hydrogen peroxide (H2O2) into cytotoxic hydroxyl radicals (•OH) for chemodynamic therapy (CDT) of the tumor. Besides, the released DOX not only merely induced the diagnosis of the tumor cells for chemotherapy (CT) but also generated H2O2 to promote CDT. Moreover, the photothermal effect of the nanoagent could use for photothermal therapy (PTT). The increasing temperature was conducive to the release of DOX from micropore into the cell, which indirectly enhanced CT and CDT effects. As an intelligent and multifunctional drug delivery platform, the present CNTs/Fe-N-C/DOX/CM nanoagent could be engineered with synergistic treatments and favorable biosafety, which provides a promising paradigm in site-specific antitumor treatment and biomedicine.

show abstract

Microfluidic synthesis of manganese-alginate nanogels with self-supplying H2O2 capability for synergistic chemo/chemodynamic therapy and boosting anticancer immunity

Cited by 37 publications

References 37 publications

New anti-cancer explorations based on metal ions

New anti-cancer explorations based on metal ions

Alginate-Based Micro- and Nanosystems for Targeted Cancer Therapy

Single-Site Fe-N-C Atom Based Carbon Nanotubes for Mutually Promoted and Synergistic Oncotherapy

Contact Info

Product

Resources

About