Microfluidic Sample Preparation for Medical Diagnostics

Cui, Francis; Rhee, Minsoung; Singh, Anup K.; Tripathi, Anubhav

doi:10.1146/annurev-bioeng-071114-040538

Cited by 111 publications

(78 citation statements)

References 89 publications

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“…The technical requirements of preanalytical procedures to extract and concentrate a biomarker prevent many in-development tests, most notably NATs, 29,31 from being implemented into POC clinical settings. Existing preanalytical procedures are also a major source of errors in laboratory diagnostics.…”

Section: Discussionmentioning

confidence: 99%

“…Commercialized paper-based sample collection and plasma separation technologies are commonly used for sample collection. 27 Novel approaches to sample preparation, including microfluidic separation techniques 28,29 and extraction and concentration techniques, 29 have been previously reviewed. However, challenges remain before unprocessed blood or other clinical samples can be applied directly to amplification and detection assays at the POC.…”

Section: Diagnostic Formatmentioning

confidence: 99%

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Point-of-care diagnostics to improve maternal and neonatal health in low-resource settings

et al. 2017

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Each day, approximately 830 women and 7,400 newborns die from complications during pregnancy and childbirth. Improving maternal and neonatal health will require bringing rapid diagnosis and treatment to the point of care in low-resource settings. However, to date there are few diagnostic tools available that can be used at the point of care to detect the leading causes of maternal and neonatal mortality in low-resource settings. Here we review both commercially available diagnostics and technologies that are currently in development to detect the leading causes of maternal and neonatal mortality, highlighting key gaps in development where innovative design could increase access to technology and enable rapid diagnosis at the bedside.

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Section: Discussionmentioning

confidence: 99%

Section: Diagnostic Formatmentioning

confidence: 99%

Point-of-care diagnostics to improve maternal and neonatal health in low-resource settings

et al. 2017

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“…This enhances the bio-recognition occurring at the bio-receptor's surface because pre-treatment of the sample reduces the risk of non-specific interaction and also reduces the presence of unwanted large size particles which shield the bioreceptor. Although research is ongoing in the field of integrated sample preparation devices [15], human manipulation is still often required. This is one of the main reasons which explains that only a few number of devices developed using the bottom-up approach leads to actual medical devices which can be used in clinical environment.…”

Section: Researcher Point Of View: the Bottom-up Approachmentioning

confidence: 99%

Medical Devices Development: The Bottom-Up or The Top-Down Approach?

Wacogne¹

2018

IJBSBE

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Biomedical sensors are often developed under a bottom-up approach, i.e. the researcher point of view or laboratory approach. This is usually the case for microfluidic based integrated systems. The small number of such devices actually translated for use in clinical situations is mostly due to the need of sample pretreatment by specially trained people and to the fact that industrial transfer had not been taken into account since the very beginning of the development. Conversely, the top-down approach places the end-user at the center of development discussion. In this end-user point of view approach, the participation of industrial, medical and end-users partners more often leads to the design of fully integrated and automated devices which, furthermore, can be manufactured using conventional industrial capabilities. In this opinion communication, we briefly summarize the most common biosensors technologies and we explain how immuno-combined devices may help addressing constraints related to their use in clinical situations in terms of usability by non-trained people, automation and integration.

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“…[38][39][40][41] On-chip polymerized monolith-based SPE has been evaluated considerably for this purpose, primarily due to strong synergy with the mature liquid chromatography field. 38,39 Porous polymer monolith stationary phases form the basis of this sample preparation approach.…”

Section: On-chip Solid Phase Extraction and Separationmentioning

confidence: 99%

Advances in monoliths and related porous materials for microfluidics

2016

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In recent years, the use of monolithic porous polymers has seen significant growth. These materials present a highly useful support for various analytical and biochemical applications. Since their introduction, various approaches have been introduced to produce monoliths in a broad range of materials. Simple preparation has enabled their easy implementation in microchannels, extending the range of applications where microfluidics can be successfully utilized. This review summarizes progress regarding monoliths and related porous materials in the field of microfluidics between 2010 and 2015. Recent developments in monolith preparation, solid-phase extraction, separations, and catalysis are critically discussed. Finally, a brief overview of the use of these porous materials for analysis of subcellular and larger structures is given.

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Microfluidic Sample Preparation for Medical Diagnostics

Cited by 111 publications

References 89 publications

Point-of-care diagnostics to improve maternal and neonatal health in low-resource settings

Point-of-care diagnostics to improve maternal and neonatal health in low-resource settings

Medical Devices Development: The Bottom-Up or The Top-Down Approach?

Advances in monoliths and related porous materials for microfluidics

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