Microfluidic resonant cavities enable acoustophoresis on a disposable superstrate

Witte, Christian; Reboud, Julien; Wilson, Rab; Cooper, Jonathan M.; Neale, Steven L.

doi:10.1039/c4lc00749b

Cited by 35 publications

(31 citation statements)

References 40 publications

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“…158 Along those lines, much of the recent focus has been on applying SAW separation to more clinically-relevant conditions, including platelets and bacteria from whole blood 153,159 and inflammatory cells from sputum. 160 While Huang’s group has been the most prolific in this area, others have also contributed 163,164 , demonstrating, for example, SAW-based separation within a surface droplet 165 or using a traveling wave approach, rather than a standing wave. 166 …”

Section: Saw-integrated Microfluidicsmentioning

confidence: 99%

Surface acoustic wave devices for chemical sensing and microfluidics: a review and perspective

et al. 2017

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Surface acoustic waves (SAWs), are electro-mechanical waves that form on the surface of piezoelectric crystals. Because they are easy to construct and operate, SAW devices have proven to be versatile and powerful platforms for either direct chemical sensing or for upstream microfluidic processing and sample preparation. This review summarizes recent advances in the development of SAW devices for chemical sensing and analysis. The use of SAW techniques for chemical detection in both gaseous and liquid media is discussed, as well as recent fabrication advances that are pointing the way for the next generation of SAW sensors. Similarly, applications and progress in using SAW devices as microfluidic platforms are covered, ranging from atomization and mixing to new approaches to lysing and cell adhesion studies. Finally, potential new directions and perspectives on the field as it moves forward are offered, with a specific focus on potential strategies for making SAW technologies for bioanalytical applications.

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Section: Saw-integrated Microfluidicsmentioning

confidence: 99%

Surface acoustic wave devices for chemical sensing and microfluidics: a review and perspective

et al. 2017

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“…Among the single‐layered PDMS‐based devices, similar kind of focusing is not reported before. Due to the utilization of the principal component of ARF, the present device successfully operated for particle separation at net flow rate up to 1.3 mL min −1 , which is ≈100 times higher than used in previously reported SAW devices 20, 23, 31, 32, 37, 38, 42, 43, 47, 48. The throughput of the proposed device can be further improved with ease by increasing the width of the microchannel since the microchannel is placed directly on the IDT.…”

Section: Introductionmentioning

confidence: 85%

Vertical Hydrodynamic Focusing and Continuous Acoustofluidic Separation of Particles via Upward Migration

et al. 2017

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A particle suspended in a fluid within a microfluidic channel experiences a direct acoustic radiation force (ARF) when traveling surface acoustic waves (TSAWs) couple with the fluid at the Rayleigh angle, thus producing two components of the ARF. Most SAW‐based microfluidic devices rely on the horizontal component of the ARF to migrate prefocused particles laterally across a microchannel width. Although the magnitude of the vertical component of the ARF is more than twice the magnitude of the horizontal component, it is long ignored due to polydimethylsiloxane (PDMS) microchannel fabrication limitations and difficulties in particle focusing along the vertical direction. In the present work, a single‐layered PDMS microfluidic chip is devised for hydrodynamically focusing particles in the vertical plane while explicitly taking advantage of the horizontal ARF component to slow down the selected particles and the stronger vertical ARF component to push the particles in the upward direction to realize continuous particle separation. The proposed particle separation device offers high‐throughput operation with purity >97% and recovery rate >99%. It is simple in its fabrication and versatile due to the single‐layered microchannel design, combined with vertical hydrodynamic focusing and the use of both the horizontal and vertical components of the ARF.

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“…The transport of traveling and standing acoustic waves using an additional buffer layer or superstrate has been reported recently for a variety of applications such as particle separation, washing and trapping (Ma et al 2016; Rambach et al 2014; Skowronek et al 2013; Witte et al 2014), droplet rotating and liquid pumping (Bourquin et al 2011; Reboud et al 2012; Wilson et al 2011), as well as cell sorting and patterning (Guo et al 2015b; Schmid et al 2014). With the incorporation of a single uniform layer (Guo et al 2015b; Ma et al 2016; Rambach et al 2014; Schmid et al 2014; Skowronek et al 2013; Witte et al 2014) or a patterned structure such as phononic crystal (Bourquin et al 2011; Reboud et al 2012; Wilson et al 2011), enhanced manipulation of the acoustic fields can be readily realized, which is otherwise difficult to achieve using conventional microfluidic channels. However, despite the significant advancements in this field, the comprehensive study on the effect of acoustofluidic waveguides with different sizes and geometries in shaping and modifying the acoustic fields in fluidics are yet to be demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Acoustofluidic waveguides for localized control of acoustic wavefront in microfluidics

Bian

Guo

Yang

et al. 2017

Microfluid Nanofluid

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The precise manipulation of acoustic fields in microfluidics is of critical importance for the realization of many biomedical applications. Despite the tremendous efforts devoted to the field of acoustofluidics during recent years, dexterous control, with an arbitrary and complex acoustic wavefront, in a prescribed, microscale region is still out of reach. Here, we introduce the concept of acoustofluidic waveguide, a three-dimensional compact configuration that is capable of locally guiding acoustic waves into a fluidic environment. Through comprehensive numerical simulations, we revealed the possibility of forming complex field patterns with defined pressure nodes within a highly localized, pre-determined region inside the microfluidic chamber. We also demonstrated the tunability of the acoustic field profile through controlling the size and shape of the waveguide geometry, as well as the operational frequency of the acoustic wave. The feasibility of the waveguide concept was experimentally verified via microparticle trapping and patterning. Our acoustofluidic waveguiding structures can be readily integrated with other microfluidic configurations and can be further designed into more complex types of passive acoustofluidic devices. The waveguide platform provides a promising alternative to current acoustic manipulation techniques and is useful in many applications such as single-cell analysis, point-of-care diagnostics, and studies of cell–cell interactions.

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Microfluidic resonant cavities enable acoustophoresis on a disposable superstrate

Cited by 35 publications

References 40 publications

Surface acoustic wave devices for chemical sensing and microfluidics: a review and perspective

Surface acoustic wave devices for chemical sensing and microfluidics: a review and perspective

Vertical Hydrodynamic Focusing and Continuous Acoustofluidic Separation of Particles via Upward Migration

Acoustofluidic waveguides for localized control of acoustic wavefront in microfluidics

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