Microfluidic preparation of polymer-lipid Janus microparticles with staged drug release property

Sun, Xiaoting; Guo, Rui; Wang, Danni; Wei, Yizhen; Yang, Chunguang; Xu, Zhang-Run

doi:10.1016/j.jcis.2019.06.069

Cited by 38 publications

(30 citation statements)

References 26 publications

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“…56 The specific design of Janus particles allows for obtaining two-compartment systems with different drug release properties displayed by each one which is extremely interesting and potentially useful in terms of controlled drug delivery. 57 On the other hand, the described systems can be used for the separate incorporation of two different drugs in one formulation. 58 Kang et al 59 presented complex alginate microspheres obtained with the use of self-developed micronozzle system designed to extrude two different alginate solutions in a parallel mode to the crosslinking medium containing calcium cations (Fig.…”

Section: Microparticlesmentioning

confidence: 99%

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Jadach¹,

Świetlik²,

Froelich³

2022

Journal of Pharmaceutical Sciences

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Alginates are naturally occurring polymers revealing low toxicity, good biocompatibility and biodegradability, excellent gelling and thickening properties, as well as low production cost and good availability. One of the most important features typical for alginates is the ability to undergo ionotropic gelation which is gel formation process occurring upon the contact with cations. Because of their advantageous properties, alginates have been extensively utilized in food and pharmaceutical industries. In this review the current knowledge regarding the most recent studies involving both popularly applied dosage forms, like tablets or hydrogels, and novel advanced drug delivery systems applied in targeted therapies are summarized and discussed. The presented studies indicate that although sodium alginate is a well-established polymer, it is still widely applied as pharmaceutical excipient and the presented research studies indicate that there are still research areas that can be explored and provide innovation in drug delivery systems.

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Section: Microparticlesmentioning

confidence: 99%

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Jadach¹,

Świetlik²,

Froelich³

2022

Journal of Pharmaceutical Sciences

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“…In addition to the phase ratio, the effect of other factors on the morphology of Janus particles were also explored. In fact, the final morphology of the droplet is determined by the interfacial tension between different phases, and the wettability between different phases is reflected by the spreading coefficient ( Si ) ( Sun et al, 2019 ). Under our experimental conditions, when the concentration of Span 80 is 0.5% (v/v), the Janus (dumbbell) shape formed.…”

Section: Resultsmentioning

confidence: 99%

Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties

Feng

Liu

Sang

et al. 2021

Front. Bioeng. Biotechnol.

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Based on the phase separation phenomenon in micro-droplets, polymer-lipid Janus particles were prepared on a microfluidic flow focusing chip. Phase separation of droplets was caused by solvent volatilization and Janus morphology was formed under the action of interfacial tension. Because phase change from solid to liquid of the lipid hemisphere could be triggered by physiological temperature, the lipid hemisphere could be used for rapid release of drugs. While the polymer we selected was pH sensitive that the polymer hemisphere could degrade under acidic conditions, making it possible to release drugs in a specific pH environment, such as tumor tissues. Janus particles with different structures were obtained by changing the experimental conditions. To widen the application range of the particles, fatty alcohol and fatty acid-based phase change materials were also employed to prepare the particles, such as 1-tetradecanol, 1-hexadecanol and lauric acid. The melting points of these substances are higher than the physiological temperature, which can be applied in fever triggered drug release or in thermotherapy. The introduction of poly (lactic-co-glycolic acid) enabled the formation of multicompartment particles with three distinct materials. With different degradation properties of each compartment, the particles generated in this work may find applications in programmed and sequential drug release triggered by multiple stimuli.

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“…[ 89 , 112 ] Janus droplets have two or more distinct physical surface properties, and can be prepared either from the conjugation of several dispersed phases without mixing, or, from the phase separation of a droplet preloaded with mixed reagents (Figure 3d ). [ 113 ] These amphiphilic microparticles harness polarization from their structures, and can enable the staged release of drugs. Moreover, microfluidics can control the surface properties and porosity of microparticles, dependent upon the emulsion systems and the inflow parameters.…”

Section: Drug Delivery Systems and Droplet‐based Technologymentioning

confidence: 99%

Droplet Microfluidics for Tumor Drug‐Related Studies and Programmable Artificial Cells

Dimitriou

Tornillo

et al. 2021

Global Challenges

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(1 of 17)www.global-challenges.com robotics, have promoted the use of in vitro tumor models in high-throughput drug screenings. [2,3] High-throughput screens for anticancer drugs have been, for a long time, limited to 2D culture of tumor cells, grown as a monolayer on the bottom of a well of a microtiter plate. Compared to 2D cell cultures, 3D culture systems can more faithfully model cell-cell interactions, matrix deposition and tumor microenvironments, including more physiological flow conditions, oxygen and nutrient gradients. [4] Therefore, 3D cultures have recently begun to be incorporated into high-throughput drug screenings, with the aim of better predicting drug efficacy and improving the prioritization of candidate drugs for further in vivo testing in animals.Because of the relatively simple, reproducible, amenable to automation and scalable culture methods, single-cell type and mixed-cell tumor spheroids, known as multicellular tumor spheroids (MCTSs), are used as 3D models. [5] There exists a broad range of natural hydrogels that are compatible with microfluidics, and which provide cancer cells with mechanical cues and adhesion sites to proliferate and grow into MCTSs. [6] With the aid of microfluidics and development of more complex 3D tumor models, [7,8] and the large-scale production of tumor spheroids in hydrogels, the number of compounds that could progress to in vivo testing could be restricted, thus reducing the number of animals needed for preclinical studies.Tumor-targeted drug delivery using microparticles and liposomes is beneficial compared to conventional drug administration. This is because encapsulated drug dosages can be controlled, healthy tissues can remain unharmed during treatment and drug resistance of cancer cells may be reduced/ prevented. [9,10] Microparticles and liposomes can be tailored to specifically target tumor sites using molecular conjugates, while avoiding toxic effects. [9] This review discusses the application of droplet-based microfluidic technologies for the development of accurate in vitro tumor models and improved cancer treatment strategies. The first part of the review centers around the generation of MCTSs in natural hydrogels for a better recapitulation of the in vivo tumor microenvironment. The second section is focused on microparticle and liposomal production for tumor-targeted drug delivery. Emphases is given to microfluidic methodologies for the production of these systems, and the potential of compartmentalized artificial cells as anticancer drug screening platforms.

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Microfluidic preparation of polymer-lipid Janus microparticles with staged drug release property

Cited by 38 publications

References 26 publications

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Microfluidic Preparation of Janus Microparticles With Temperature and pH Triggered Degradation Properties

Droplet Microfluidics for Tumor Drug‐Related Studies and Programmable Artificial Cells

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