Microfluidic platform with integrated electrical actuator to enrich and locating atypical/cancer cells from liquid cytology samples

Jahangiri, Mojtaba; Khosravi, Shahla; Moghtaderi, Hassan; Ranjbar, Malek Mohammad; Abadijoo, Hamed; Sarmadi, Soheila; Izadi-Mood, Narges; Shirali, Elham; Hoseinpour, Parisa; Gity, Masoumeh; Abbasvandi, Fereshteh; Mohajerzadeh, Leily; Aghdam, Maryam Kazemi; Abdolahad, Mohammad

doi:10.1016/j.snb.2019.126733

Cited by 7 publications

(1 citation statement)

References 36 publications

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“…The 20 nm Cr layer was used in order to enhance the 100 nm Au layer adhesion to the glass substrate. Using standard photolithography ( Jahangiri et al, 2019 ; 2020 ), the eight electrodes were patterned on the surface of Au coated glass. The patterned electrodes were passivated using a 4 µm layer of PDMS by spin coating at 6000 rpm for 5 min.…”

Section: Methodsmentioning

confidence: 99%

Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients

Abadijoo

Khayamian

Faramarzpour

et al. 2022

Front. Bioeng. Biotechnol.

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In the case of the COVID-19 early diagnosis, numerous tech innovations have been introduced, and many are currently employed worldwide. But, all of the medical procedures for the treatment of this disease, up to now, are just limited to chemical drugs. All of the scientists believe that the major challenge toward the mortality of the COVID-19 patients is the out-of-control immune system activation and the subsequent cytokine production. During this process, the adaptive immune system is highly activated, and many of the lymphocytes start to clonally expand; hence many cytokines are also released. So, any attempt to harness this cytokine storm and calm down the immune outrage is appreciated. While the battleground for the immune hyperactivation is the lung ambient of the infected patients, the only medical treatment for suppressing the hypercytokinemia is based on the immunosuppressor drugs that systemically dampen the immunity with many unavoidable side effects. Here, we applied the alternating electric field to suppress the expansion of the highly activated lymphocytes, and by reducing the number of the renewed cells, the produced cytokines were also decreased. Applying this method to the blood of the COVID-19 patients in vitro showed ∼33% reduction in the average concentration of the three main cytokines after 4 days of stimulation. This method could carefully be utilized to locally suppress the hyperactivated immune cells in the lung of the COVID-19 patients without any need for systemic suppression of the immune system by the chemical drugs.

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Section: Methodsmentioning

confidence: 99%