Microfluidic pervaporation of ethanol from radiopharmaceutical formulations

Zizzari, Alessandra; Bianco, Monica; Perrone, Elisabetta; Manera, Maria Grazia; Cellamare, Saverio; Ferorelli, Savina; Purgatorio, Rosa; Scilimati, Antonio; Tolomeo, Anna; Dimiccoli, V.; Rella, R.; Arima, Valentina

doi:10.1016/j.cep.2019.107539

Cited by 8 publications

(10 citation statements)

References 43 publications

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“…As demonstrated by Zizzari, the working temperature was expected to influence the pervaporation efficiency because the temperature affected the saturation pressure of each target compounds. Permeability was inversely proportional to the thickness of the membrane .…”

Section: Resultsmentioning

confidence: 99%

“…Polydimethylsiloxane (PDMS) membranes are non-porous and dense polymeric films. The dissolution and diffusion of the components take place on the PDMS membranes which was driven by the difference in the vapor partial pressure . This type of PDMS membrane pervaporation chip device has been used for acetone removal and ethanol removal at the chemical industrial scale.…”

Section: Introductionmentioning

confidence: 99%

“…The dissolution and diffusion of the components take place on the PDMS membranes which was driven by the difference in the vapor partial pressure. 24 This type of PDMS membrane pervaporation chip device has been used for acetone removal 25 and ethanol removal 24 at the chemical industrial scale. In the field of detection, the Breadmore group 26 has reported on an automated on-line solvent exchange system by a vapor permeable membrane integrated with highperformance liquid chromatography (HPLC) analysis.…”

Section: ■ Introductionmentioning

confidence: 99%

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Fully Automatic Multi-Class Multi-Residue Analysis of Veterinary Drugs Simultaneously in an Integrated Chip-MS Platform

Tang

Zhang

et al. 2021

J. Agric. Food Chem.

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Microfluidic chip analysis has great potential advantages such as high integration, fast speed analysis, and automatic operation and is widely used not only in biological fields but also in many other analytical areas such as agriculture and food safety. Herein, a fully automatic multi-class multi-residue analysis of veterinary drugs simultaneously in an integrated chip-mass spectrometry (chip-MS) platform was developed. The developed microfluidic chip platform integrated three modules including the extraction and filtration module, "pass-through" clean-up module, and online evaporation module. The resulting chip has been coupled to a MS detector successfully, in which 23 kinds of residues in five classes were simultaneously qualitatively and quantitatively detected without chromatographic separation, obtaining the limits of detection of the spiked milk sample in the range of 0.23−4.13 ng/mL and the recovery rate in the range from 71.7 to 118.0% under optimized conditions. The microfluidic chip system developed in this study provided a new idea for the development of detection chips and exhibited considerable potential in the point-of-care testing in milk.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fully Automatic Multi-Class Multi-Residue Analysis of Veterinary Drugs Simultaneously in an Integrated Chip-MS Platform

Tang

Zhang

et al. 2021

J. Agric. Food Chem.

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“…Patterning of microfluidic devices in glass supports/matrices is interesting to fabricate highly performant Lab-on-a-Chip (LoC) and Organ-on-a-Chip (OoC) devices for biological, medical and chemical applications [ [1] , [2] , [3] ] as well as to implement optofluidic elements [ 4 ]. Respect to other materials, such as polydimethylsiloxane (PDMS), Poly (methyl methacrylate) (PMMA) and SU-8 [ 5 , 6 ], glass is a convenient choice for manufacturing microfluidic chips due to its optical transparency, physical stability, chemical inertness, reusability, insulating properties, good dielectric properties, thermal stability, high resistance to mechanical stress, high solvent compatibility, biocompatibility and the possibility to process its surface for bonding to common micro-fabrication materials and for (bio)molecular functionalization [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Micro-structures of hundreds of microns were laser-ablated at room temperature within (22 ± 2) °C, (estimated etching rate of 34 μm/s) without the need of reagents-resistant masks, followed by a 2h lasting post-ablation wet etching to remove residual ripples and rims stemming from the thermal-ablation regime. The structures produced by laser ablation were assessed in terms of specific applications: the grooves as multi-channels to fabricate microfluidic reactors [ 6 , 39 , 40 ] and the micro-holes as molds for micro-pillars enabling studies of 3D cell cultures [ 41 , 42 ]. To the best of our knowledge, these are the first examples of CO 2 laser-engraved serpentine quartz micro-reactors reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Potential of CO2-laser processing of quartz for fast prototyping of microfluidic reactors and templates for 3D cell assembly over large scale

Perrone

Cesaria

Zizzari

et al. 2021

Materials Today Bio

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Carbon dioxide (CO 2 )-laser processing of glasses is a versatile maskless writing technique to engrave micro-structures with flexible control on shape and size. In this study, we present the fabrication of hundreds of microns quartz micro-channels and micro-holes by pulsed CO 2 -laser ablation with a focus on the great potential of the technique in microfluidics and biomedical applications. After discussing the impact of the laser processing parameters on the design process, we illustrate specific applications. First, we demonstrate the use of a serpentine microfluidic reactor prepared by combining CO 2 -laser ablation and post-ablation wet etching to remove surface features stemming from laser-texturing that are undesirable for channel sealing. Then, cyclic olefin copolymer micro-pillars are fabricated using laser-processed micro-holes as molds with high detail replication. The hundreds of microns conical and square pyramidal shaped pillars are used as templates to drive 3D cell assembly. Human Umbilical Vein Endothelial Cells are found to assemble in a compact and wrapping way around the micro-pillars forming a tight junction network. These applications are interesting for both Lab-on-a-Chip and Organ-on-a-Chip devices.

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Microfluidic Evaporation, Pervaporation, and Osmosis: From Passive Pumping to Solute Concentration

2021

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Evaporation, pervaporation, and forward osmosis are processes leading to a mass transfer of solvent across an interface: gas/liquid for evaporation and solid/liquid (membrane) for pervaporation and osmosis. This Review provides comprehensive insight into the use of these processes at the microfluidic scales for applications ranging from passive pumping to the screening of phase diagrams and micromaterials engineering. Indeed, for a fixed interface relative to the microfluidic chip, these processes passively induce flows driven only by gradients of chemical potential. As a consequence, these passive-transport phenomena lead to an accumulation of solutes that cannot cross the interface and thus concentrate solutions in the microfluidic chip up to high concentration regimes, possibly up to solidification. The purpose of this Review is to provide a unified description of these processes and associated microfluidic applications to highlight the differences and similarities between these three passive-transport phenomena.

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Microfluidic pervaporation of ethanol from radiopharmaceutical formulations

Cited by 8 publications

References 43 publications

Fully Automatic Multi-Class Multi-Residue Analysis of Veterinary Drugs Simultaneously in an Integrated Chip-MS Platform

Fully Automatic Multi-Class Multi-Residue Analysis of Veterinary Drugs Simultaneously in an Integrated Chip-MS Platform

Potential of CO2-laser processing of quartz for fast prototyping of microfluidic reactors and templates for 3D cell assembly over large scale

Microfluidic Evaporation, Pervaporation, and Osmosis: From Passive Pumping to Solute Concentration

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