Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

Xin, Hao; Du, Ting; He, Huatao; Yang, Feng; Wang, Yilan; Liu, Gang; Wang, Yaolei

doi:10.1002/admi.202102184

Cited by 6 publications

(4 citation statements)

References 180 publications

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“…Each phase in these systems ensures the production of particles in the appropriate size and shape, as well as is the desired physical, chemical, and biological properties. In this way, thy can be used to develop particles with complex structures such as core-shell, multi-core-shell, janus, and porous ones [ 255 ]. The formation of particles from monodisperse droplets occurs using various methods such as polymerization, ionic crosslinking, and solvent evaporation [ 254 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. This review provides a comprehensive overview of the significant advances that have been made in the development of microfluidics devices. We will discuss the function of microfluidic devices as micromixers or as sorters of cells and substances (e.g., microfiltration, flow or displacement, and trapping). Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). An anticipated development in the field includes the optimization of techniques for the fabrication of microfluidic devices using biocompatible materials. These developments will increase biomedical versatility, reduce diagnostic costs, and accelerate diagnosis time of microfluidics technology.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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“…[ 5 ] The use of hydrogels is a consequence of their being composed of a large amount of water and a crosslinked polymer network that provides physical similarity to the extracellular matrix and the capability to easily encapsulate drugs. [ 6 ] Cell and cytokine therapeutics can be significantly enhanced via encapsulation within hydrogels, [ 7 ] due to stabilization during delivery, [ 2b,8 ] protection from the immune system in vivo, [ 9 ] and localization to the intended delivery region, [ 10 ] ultimately extending the therapeutic window.…”

Section: Introductionmentioning

confidence: 99%

Fibro‐Gel: An All‐Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and its Application in Wound Healing

et al. 2023

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Injectable hydrogels are valuable tools in tissue engineering and regenerative medicine due to their unique advantages of injectability with minimal invasiveness and usability for irregularly shaped sites. However, it remains challenging to achieve scalable manufacturing together with matching physicochemical properties and on‐demand drug release for a high level of control over biophysical and biomedical cues to direct endogenous cells. Here, the use of an injectable fibro‐gel is demonstrated, a water‐filled network of entangled hydrogel microfibers, whose physicochemical properties and drug release profiles can be tailored to overcome these shortcomings. This fibro‐gel exhibits favorable in vitro biocompatibility and the capability to aid vascularization. The potential use of the fibro‐gel for advancing tissue regeneration is explored with a mice excision skin model. Preliminary in vivo tests indicate that the fibro‐gel promotes wound healing and new healthy tissue regeneration at a faster rate than a commercial gel. Moreover, it is demonstrated that the release of distinct drugs at different rates can further accelerate wound healing with higher efficiency, by using a two‐layer fibro‐gel model. The combination of injectability and tailorable properties of this fibro‐gel offers a promising approach in biomedical fields such as therapeutic delivery, medical dressings, and 3D tissue scaffolds for tissue engineering.

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“…More complicated dispersed phases, such as Janus drops, have attracted the attention of researchers, due mainly to their wide applications, e.g. biomedicine (Hao et al 2022), drug delivery (Song et al 2021) and material science (Wei et al 2022). Here, Janus droplets refer to compound drops consisting of two component droplets (of different fluids) in contact.…”

Section: Introductionmentioning

confidence: 99%

Two-dimensional Janus drops in shear: deformation, rotation and their coupling

Zhang,

Chen,

Qian

et al. 2023

J. Fluid Mech.

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In this work, the dynamics of two-dimensional rotating Janus drops in shear flow is studied numerically using a ternary-fluid diffuse interface method. The rotation of Janus drops is found to be closely related to their deformation. A new deformation parameter $D$ is proposed to assess the significance of the drop deformation. According to the maximum value of $D$ ( $D_{max}$ ), the deformation of rotating Janus drops can be classified into linear deformation ( $D_{max}\le 0.2$ ) and nonlinear deformation ( $D_{max}> 0.2$ ). In particular, $D_{max}$ in the former depends linearly on the Reynolds and capillary numbers, which can be interpreted by a mass–spring model. Furthermore, the rotation period $t_R$ of a Janus drop is found to be more sensitive to the drop deformation than to the aspect ratio of the drop at equilibrium. By introducing a corrected shear rate and an aspect ratio of drop deformation, a rotation model for Janus drops is established based on Jeffery's theory for rigid particles, and it agrees well with our numerical results.

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Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

Cited by 6 publications

References 180 publications

Biomedical Applications of Microfluidic Devices: A Review

Biomedical Applications of Microfluidic Devices: A Review

Fibro‐Gel: An All‐Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and its Application in Wound Healing

Two-dimensional Janus drops in shear: deformation, rotation and their coupling

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