Microfluidic Paper-Based Devices for Bioanalytical Applications

Abstract

Paper has become increasingly recognized as a very interesting substrate for the construction of microfluidic devices, with potential application in a variety of areas, including health diagnosis, environmental monitoring, immunoassays and food safety. The aim of this review is to present a short history of analytical systems constructed from paper, summarize the main advantages and disadvantages of fabrication techniques, exploit alternative methods of detection such as colorimetric, electrochemical, photoelectrochemical, chemiluminescence and electrochemiluminescence, as well as to take a closer look at the novel achievements in the field of bioanalysis published during the last 2 years. Finally, the future trends for production of such devices are discussed.

Diagnosis of communicable diseases using papepr microfluidic platforms

“…the fluid flow is unsteady uniform [10]. The position of the fluid front with respect to time can be modelled by the Lucas-Washburn equation [11]. …”

“…The conventional methods used for creating hydrophobic barriers are inkjet printing [17][18][19], wax printing [20,21], flexographic printing [22], photolithography [23], wax dipping [24], plasma treatment [19,25], screenprinting of poly(dimethylsiloxane) (PDMS) [15], lacquer spraying [26] and using a permanent marker [27]. The details of these fabrication methods have been studied comprehensively by several researchers [11,28,29]. The selection of fabrication methodology is primarily dependent on the nature of the reagents used and the resolution required by the device [11].…”

“…The details of these fabrication methods have been studied comprehensively by several researchers [11,28,29]. The selection of fabrication methodology is primarily dependent on the nature of the reagents used and the resolution required by the device [11].…”

Portable system for photodiode-based electrochemiluminescence measurement with improved limit of detection

“…ECL has great potential as an analytical technique and has been implemented in different analytical designs [1][2][3][4][5][6]. Proof of the interest in this technique among the scientific community is the exponential growth of papers on ECL analysis (3,938 papers in the last 20 years, doubling every 7 years; source: SciFinder).…”

Paper‐Based Inkjet‐Printed Microfluidic Analytical Devices

“…[7] Although still relatively young, the topic of microfluidic paper-based analytical devices has been reviewed multiple times and the list of references given here is probably not complete. [2,3,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Similarly, there are several reviews on the application of inkjet printing for material deposition. [5,[24][25][26][27][28][29][30] Whereas previous reviews mostly focused on the analytical applications of mPADs, the purpose of the present Review is to discuss the basics, strengths, and weaknesses related to the application of inkjet printing technology for the fabrication of mPADs.…”