Microfluidic method for measuring viscosity using images from smartphone

Kim, Sooyeong; Kim, Kyung Chun; Yeom, Eunseop

doi:10.1016/j.optlaseng.2017.05.016

Cited by 42 publications

(23 citation statements)

References 36 publications

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“…The coupling of smartphones to microfluidic platform is feasible and has already been done with other microfluidic systems. [31,32] As shown in Figure 1, our system was more compact and portable than conventional systems based on digital microscopes and external monitors; our system was easily assembled inside a laminar flow hood (Figure 1A). Moreover, the quality of images obtained during microgel production (Figure 1B) provided sufficient resolution to identify individual gels and is comparable with images in literature.…”

Section: Discussionmentioning

confidence: 99%

Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking

et al. 2021

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Efficient delivery of nanometric vectors complexed with nanoparticles at a target tissue without spreading to other tissues is one of the main challenges in gene therapy. One means to overcome this problem is to confine such vectors within microgels that can be placed in a target tissue to be released slowly and locally. Herein, a conventional optical microscope coupled to a common smartphone was employed to monitor the microfluidic production of monodisperse alginate microgels containing nanoparticles as a model for the encapsulation of vectors. Alginate microgels (1.2%) exhibited an average diameter of 125 ± 3 μm, which decreased to 106 ± 5 μm after encapsulating 30 nm fluorescent nanoparticles. The encapsulation efficiency was 70.9 ± 18.9%. In a 0.1 M NaCl solution, 55 ± 5% and 92 ± 4.7% of nanoparticles were released in 30 minutes and 48 hours, respectively. Microgel topography assessment by atomic force microscopy revealed that incorporation of nanoparticles into the alginate matrix changes the scaffold's interfacial morphology and induces crystallization with the appearance of oriented domains. The high encapsulation rate of nanoparticles, alongside their continuous release of nanoparticles over time, makes these microgels and the production unit a valuable system for vector encapsulation for gene therapy research.

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Section: Discussionmentioning

confidence: 99%

Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking

et al. 2021

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“…Figure 2A shows the microfluidic system consisting of a pressure sensor and a syringe pump to push and pull the blood inside the microfluidic channel (Jain et al, 2016a). Kim et al demonstrated a smart phone based viscometer that monitors the interfacial width in images from a Y shaped channel, while the ratio of the pressure in the blood channel (sample) over the pressure in PBS channel (reference) is correlated with the width ratio of the sample flow W/W total (Kim et al, 2018). Li et al developed a paper based microfluidic lateral flow device (see Figure 2B) in which the traveling distance of RBC cells in a cellulose membrane was correlated with the blood clotting time (Li et al, 2014).…”

Section: Poc Tests Based On Electromechanical Measurementsmentioning

confidence: 99%

Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing

Aria

Erten

Yalçın

2019

Front. Bioeng. Biotechnol.

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In recent years, blood coagulation monitoring has become crucial to diagnosing causes of hemorrhages, developing anticoagulant drugs, assessing bleeding risk in extensive surgery procedures and dialysis, and investigating the efficacy of hemostatic therapies. In this regard, advanced technologies such as microfluidics, fluorescent microscopy, electrochemical sensing, photoacoustic detection, and micro/nano electromechanical systems (MEMS/NEMS) have been employed to develop highly accurate, robust, and cost-effective point of care (POC) devices. These devices measure electrochemical, optical, and mechanical parameters of clotting blood. Which can be correlated to light transmission/scattering, electrical impedance, and viscoelastic properties. In this regard, this paper discusses the working principles of blood coagulation monitoring, physical and sensing parameters in different technologies. In addition, we discussed the recent progress in developing nanomaterials for blood coagulation detection and treatments which opens up new area of controlling and monitoring of coagulation at the same time in the future. Moreover, commercial products, future trends/challenges in blood coagulation monitoring including novel anticoagulant therapies, multiplexed sensing platforms, and the application of artificial intelligence in diagnosis and monitoring have been included.

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“…By measuring the diameter of the inner phase ( Figure 13) and by solving the Navier-Stokes equations, they were able to determine the viscosity of one fluid knowing the one of the other. Taking advantage of new technologies available to the general public, Kim et al 71 developed a hybrid system with a smartphone camera coupled with an objective lens and a Y-junction microfluidic device for viscosity measurement ( Figure 14). Their work is based on the same physical principle as discussed before.…”

Section: Viscositymentioning

confidence: 99%

Microfluidic approaches for accessing thermophysical properties of fluid systems

et al. 2019

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Microfluidic method for measuring viscosity using images from smartphone

Cited by 42 publications

References 36 publications

Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking

Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking

Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing

Microfluidic approaches for accessing thermophysical properties of fluid systems

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