2019
DOI: 10.3389/fbioe.2019.00395
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Abstract: In recent years, blood coagulation monitoring has become crucial to diagnosing causes of hemorrhages, developing anticoagulant drugs, assessing bleeding risk in extensive surgery procedures and dialysis, and investigating the efficacy of hemostatic therapies. In this regard, advanced technologies such as microfluidics, fluorescent microscopy, electrochemical sensing, photoacoustic detection, and micro/nano electromechanical systems (MEMS/NEMS) have been employed to develop highly accurate, robust, and cost-eff… Show more

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Cited by 52 publications
(29 citation statements)
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References 154 publications
(160 reference statements)
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“…Several emerging technologies are currently in development for point-of-care hemostatic testing, including microfluidics, fluorescent microscopy, electrochemical sensing, photoacoustic detection, and micro/nano electromechanical systems (MEMS/NEMS) [28]. In the section below, we outline several new devices/technologies that are currently under investigation for use as viscoelastic hemostatic assays; however, these technologies may also have other applications, such as monitoring microfluid dynamics and shear force in coagulation [29][30][31][32][33][34].…”
Section: Emerging Technologiesmentioning
confidence: 99%
“…Several emerging technologies are currently in development for point-of-care hemostatic testing, including microfluidics, fluorescent microscopy, electrochemical sensing, photoacoustic detection, and micro/nano electromechanical systems (MEMS/NEMS) [28]. In the section below, we outline several new devices/technologies that are currently under investigation for use as viscoelastic hemostatic assays; however, these technologies may also have other applications, such as monitoring microfluid dynamics and shear force in coagulation [29][30][31][32][33][34].…”
Section: Emerging Technologiesmentioning
confidence: 99%
“…Owing to recent developments in microfluidic technology, several hemorheological point-of-care devices have been designed that allow the possibility of conducting extensive clinical studies using hemorheological measurements [ 6 , 33 ]. The field of microfluidics technology is characterized by the study and manipulation of fluids in microstructures at the submillimeter length scale and it has emerged as an important tool to be applied in many engineering and biomedical fields [ 34 ].…”
Section: Microfluidics Tools: Single-cell Approachmentioning
confidence: 99%
“…Outside the clinical laboratory there is an array of POCT devices available for the PT/INR test, some often combining the measurement of the aPTT and ACT in a single instrument (Table II). 19 Despite the availability of POCT devices in haemostasis testing, their widespread use for measuring the PT (other than monitoring the INR) to date is limited. 12…”
Section: Point-of-care Testing: the Prothrombin Timementioning
confidence: 99%