Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery

Li, Paul C. H.

doi:10.1201/9781420027457

Cited by 80 publications

(79 citation statements)

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“…Consequently, in order to guarantee a higher cost-effectiveness as well as a significant speed-up and to allow for an in-situ investigation of the enantiomer separation at a high time-resolution, there is the need for alternative techniques. Such techniques have been provided by chiral separation in microfluidic devices taking advantage of the fact that enantiomers drift in microflows with a direction depending on their chirality (cf., e.g., [7,21,22,25,26,35]). In this paper, we are concerned with the separation of deformable vesicle-like enantiomers by a specific flow pattern generated by surface acoustic waves (SAWs).…”

Section: Left-and Right-handed Enantiomermentioning

confidence: 99%

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

et al. 2015

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Abstract. Enantiomers are chiral objects such as chemical molecules that can be distinguished by their handedness. They typically occur as racemic compounds of left-and right-handed species which may have completely different properties. Therefore, in applications such as drug design in pharmacology, enantiomer separation is an important issue. Here, we present a new technology for enantiomer separation by surface acoustic wave generated vorticity patterns consisting of pairwise counter-rotating vortices in a carrier fluid. The enantiomers are injected onto the surface of the fluid between two counter-rotating vortices such that right-handed (left-handed) enantiomers get attracted by left-rotating (right-rotating) vortices. In particular, we are concerned with the numerical simulation of this separation process by an application of the finite element immersed boundary method which relies on the solution of a coupled system consisting of the incompressible NavierStokes equations and the equations of motion of the immersed enantiomers described with respect to an Eulerian and a Lagrangian coordinate system. For a model system of deformable, initially L-shaped enantiomers the results of the numerical simulations reveal a perfect separation.

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Section: Left-and Right-handed Enantiomermentioning

confidence: 99%

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

et al. 2015

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“…Lab-on-chip technology focuses on hybrid devices integrating fluidic and electronic components onto the same chip [3,4]. A typical lab-on-chip device contains microchannels, measurands, sensors, signal conditioning front-ends, analogue-to-digital converters (ADC) and a digital signal processor which analyses the signal.…”

Section: Lab-on-chip Devicementioning

confidence: 99%

Microfluidics and Artificial Blood Vessels as Vascular Prostheses: One Small Step for Vascular Research, One Giant Leap for Patient-Kind

Yang¹

2016

J Biomol Res Ther

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Studies show that in the US alone, approximately 8 million people are affected by Peripheral Vascular Disease and approximately 26.6 million have cardiovascular disease. This report will discuss the usage of lab-on-a-chip devices and artificial blood vessels as vascular prostheses and compare the strengths and weaknesses of the two methods to measure relative efficacy and possible applications in the fields of angiology and cardiology. Lab-ona-chip devices, machines which operate on a liquid scale of micro-or nano-meters and manipulate blood flow and shear stress, may be used as long-term, compact prostheses for smaller blood vessels. Artificial, man-made blood vessels, made either from cells or synthetic material, are become increasingly effective when they are made larger. Both methods may someday be instrumental in saving lives and eliminating vascular disease.

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“…A metal mask was instead transferred to the glass substrates using a lift-off process (Fig. 4) [16].…”

Section: Asymmetric Ratchet Devicesmentioning

confidence: 99%

Combining Nondeterministic Separation and Chemical Interactions for Concentration of Nanoparticles

Malanoski¹,

White²,

Erickson³

2012

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Standard Form 298 (Rev. 8-98)Prescribed by ANSI Std. Z39.18Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) SPONSOR / MONITOR'S ACRONYM(S) 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) SPONSOR / MONITOR'S REPORT NUMBER(S) NRLThis report summarizes the results of studies conducted to evaluate the potential utility of separation techniques based on Brownian motion. Two generations of ratchet devices and four different chemical functionalities were evaluated. The devices were used to alter concentration profiles for polystyrene nanoparticles in aqueous solutions. Key paramaters such as feature size, flow rate, and particle concentration were considered. The study demonstrated that nondeterministic separation has potential for application to continuous separation of nanoparticle materials. In addition, it demonstrated that chemical surface functionalities can be used to significantly alter the performance of the devices.

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Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery

Cited by 80 publications

References 0 publications

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

Numerical simulation of surface acoustic wave actuated enantiomer separation by the finite element immersed boundary method

Microfluidics and Artificial Blood Vessels as Vascular Prostheses: One Small Step for Vascular Research, One Giant Leap for Patient-Kind

Combining Nondeterministic Separation and Chemical Interactions for Concentration of Nanoparticles

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