Microfluidic fabrication of porous polydimethylsiloxane microparticles for the treatment of toluene-contaminated water

Lian, Zheng; Ren, Yong; He, Jun; Koh, Kai Seng

doi:10.1007/s10404-018-2157-y

Cited by 22 publications

(14 citation statements)

References 56 publications

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“…For reference, other types of PDMS are referred to as PDMS-P (pristine PDMS), PDMS-M (PDMS + MWCNTs), PDMS-T (PDMS + TiO 2 , anatase titanium dioxide purchased from Aladdin, China) that were fabricated in the same manner. In the previous studies, it was found that for a type of microparticles, the amount of pollutant removed was mainly dependent on the mass of particles released instead of particle sizes, 9,49 hence in this research the investigation was focused on the effect of mass loading. In line with this, the ow rates of each phase and modes of needles, which could determine the sizes of microparticles were thus xed in this study.…”

Section: Fabrication Of Pdms-mwcnts/tio 2 Microparticles By Microuidicsmentioning

confidence: 99%

Synergetic treatment of dye contaminated wastewater using microparticles functionalized with carbon nanotubes/titanium dioxide nanocomposites

et al. 2020

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Section: Fabrication Of Pdms-mwcnts/tio 2 Microparticles By Microuidicsmentioning

confidence: 99%

Synergetic treatment of dye contaminated wastewater using microparticles functionalized with carbon nanotubes/titanium dioxide nanocomposites

et al. 2020

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“…Additionally, assembling offthe-shelf components such as dispensing needles, mini crosslinks, and tee-links was demonstrated to form emulsion generators that can produce microdroplets with precisely controlled sizes and structures. 10,11 With 3D printed multi-way connectors, parallelisation of multiple needle-based devices was achieved to further improve the production efficiency. 12 Other off-chip approaches, such as membrane-based emulsification, 13,14 cross-interface emulsification, 15 acoustic droplet ejection, [16][17][18] yield-stress fluid-enabled emulsification, 19 particle-templated emulsification, 20 and inair liquid ejection, 21,22 have demonstrated their abilities in microdroplet production.…”

Section: Introductionmentioning

confidence: 99%

Modular off-chip emulsion generator enabled by a revolving needle

et al. 2020

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“…Drug-loaded microparticles with porous structure can also be prepared with microfluidic technique in a pathway similar to that of the core-shell structure, with the addition of some poreforming substances, such as ammonium bicarbonate, hydrogen peroxide, etc., in the internal phase (Figure 4). [50][51][52] These porogens decompose to generate carbon dioxide, ammonia, oxygen, and other gases, which are subsequently released to the surrounding environment through the shell layer, leaving drugloaded microparticles with porous structure in place. Drugs can be loaded either on the surface or in the interior of porous microparticles.…”

Section: Porous Structure Microparticlesmentioning

confidence: 99%

Microfluidic‐Generated Biopolymer Microparticles as Cargo Delivery Systems

Chen

Lan

Ling

et al. 2021

Adv Materials Technologies

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to achieve better treatments, such as low drug utilization in vivo, toxic and side effects, as well as frequent medications to maintain drug efficacy in vivo. [7] Nowadays, the pharmaceutical research has gradually shifted to the development and exploration of new drug release systems as traditional pharmaceutical administration such as injections, tablets, capsules, patches, and aerosols can no longer meet the needs of clinical use. Drug release system refers to the combination of actives and biological carrier materials, which allows drugs to be released to target tissues after oral/injection by functionalizing the surface of the microparticles with molecules or antibodies, and it has facilitated the diagnosis and therapy of cancer. [8,9] For example, developments in liposome-based drug delivery systems can provide reduced side effects, improved pharmacokinetics, and increased tumor uptake for pancreatic cancer therapy; [10] Progress in 5-Fluorouracil-loaded magnetic core-shell nanoparticles allows active therapy with digestive carcinoid; [11] Developments in folate-decorated maleilated pullulan-doxorubicin conjugate provides enhanced cellular uptake and higher cytotoxicity for stomach cancer therapy; [12] Advancement of lipidpolymer hybrid microsystem allows site-specific release of encapsulated drugs to treat breast cancer. [9] In general, the carrier materials of drug release system often employ synthetic or natural polymers which normally offer great biodegradability, stimuli-responsiveness for controlled release, and good biocompatibility. Typical examples include chitosan, collagen, polylactic acid (PLA), polyglycolic acid, lactic acid-glycolic acid copolymer, polycaprolactone (PCL), etc. [13][14][15][16] These carrier materials are continuously degrading after administration, and the controlled release of the drug can be achieved through diffusion, swelling, erosion, or biodegradation. Drugs or biological actives can be either physically or chemically encapsulated in such polymer materials to prepare microparticles with size at the micron scale (1 to 500 µm). [17][18][19] Currently, common methods used to fabricate drug-loaded microparticles mainly consist of solvent evaporation and spray drying. [20] These traditional methods rely on mechanical agitation or ultrasonic vibration to synthesize microparticles, which leads to drawbacks of high polydispersibility, low drug encapsulation, and uncontrollable drug release. [21] Droplet microfluidics offers precise and simultaneous control of multiple fluids at microscale, which enables synthesis of novel microparticles with compositional and structural diversity in a controllable way. The morphology and functionality of generated microparticles can be well designed by modulating the hydrodynamic profile as well as geometric structures. The synergistic combination of droplet microfluidics with biodegradable materials makes it possible to encapsulate actives/drugs inside microparticles at high efficiency for drug delivery. The utilization of these microfluidic-ge...

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Microfluidic fabrication of porous polydimethylsiloxane microparticles for the treatment of toluene-contaminated water

Cited by 22 publications

References 56 publications

Synergetic treatment of dye contaminated wastewater using microparticles functionalized with carbon nanotubes/titanium dioxide nanocomposites

Synergetic treatment of dye contaminated wastewater using microparticles functionalized with carbon nanotubes/titanium dioxide nanocomposites

Modular off-chip emulsion generator enabled by a revolving needle

Microfluidic‐Generated Biopolymer Microparticles as Cargo Delivery Systems

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