Microfluidic devices powered by integrated elasto-magnetic pumps

Binsley, Jacob L.; Martin, Elizabeth L.; Myers, Thomas O.; Pagliara, Stefano; Ogrin, F. Y.

doi:10.1039/d0lc00935k

Cited by 10 publications

(17 citation statements)

References 73 publications

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“…These simulations are based on previous experiments from the same authors, 49 and a brief summary is provided here: A microfluidic device with an embedded elasto-magnetic pump was fabricated from PDMS and an embedded NdFeB magnet ( Fig. 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…2 ) was created to match the experimental system. 49 This depicts the octagonal pumping chamber containing an elasto-magnetic pump, connected to a rectangular cross-section inlet and outlet of appropriate length, included to ensure appropriate hydraulic resistance. The octagonal shape of the pumping chamber is chosen to encourage impedance matching between the channels and the greater width required to accommodate the pump.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we produced an experimental device that showed successful flow production as an integrated microfluidic pump. 49 This consisted of an elasto-magnetic pump driven by an oscillating magnetic field and fabricated using the common manufacturing method of monolayer lithography. The device borrows from the principles of Purcell’s three-link swimmer, 50–54 which is the simplest device capable of swimming in the Stokes regime.…”

Section: Introductionmentioning

confidence: 99%

“…This nonreciprocal motion is not symmetric in time and, thus, generates net fluid flow without relying on an inertial fluid. In our own Purcell-like system, 49 the action of the hinges is replaced by the bending imposed upon three elasticated links being driven at the free end. The phase difference is generated passively by a lag between the links as the induced wave propagates down its length.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, we were unable to fully characterize the system with measurements such as investigating the phase lag between driving torque and pump motion, a metric that has been implicated as an optimality criterion. 49,56 …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Numerical investigation of flexible Purcell-like integrated microfluidic pumps

Binsley

Pagliara

Ogrin

2022

Journal of Applied Physics

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Integrating miniature pumps within microfluidic devices is crucial for advancing point-of-care diagnostics. Understanding the emergence of flow from novel integrated pumping systems is the first step in their successful implementation. A Purcell-like elasto-magnetic integrated microfluidic pump has been simulated in COMSOL Multiphysics and its performance has been investigated and evaluated. An elastic, cilia-like element contains an embedded magnet, which allows for actuation via a weak, uniaxial, sinusoidally oscillating, external magnetic field. Pumping performance is correlated against a number of variables, such as the frequency of the driving field and the proximity of the pump to the channel walls, in order to understand the emergence of the pumping behavior. Crucially, these simulations capture many of the trends observed experimentally and shed light on the key interactions. The proximity of the channel walls in the in-plane direction strongly determines the direction of net fluid flow. This characterization has important implications for the design and optimization of this pump in practical applications.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Numerical investigation of flexible Purcell-like integrated microfluidic pumps

Binsley

Pagliara

Ogrin

2022

Journal of Applied Physics

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A 3D printed acoustofluidic nozzle-diffuser microfluidic pump

Yetiskin,

Gucluer,

Erdem

et al. 2024

Microfluid Nanofluid

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Microfluidic flow control systems are critical components for on-chip biomedical applications. This study introduces a new micropump for on-chip sample preparation and analysis by using an acoustic nozzle diffuser mechanism. The micropump implements a commercially available transducer and control board kit with 3D-printed fluid reservoirs. In this micropump, conic-shaped micro-holes on the metal sheet cover of the transducer are employed as oscillating nozzle diffuser micro arrays to achieve directional flow control. The micropump is shown to efficiently pump water and particle mixtures exceeding flow rates of 515 µl/min at a 12-volt input voltage. In addition, owing to the small size of the nozzle hole opening, larger particles can also be filtered out from a sample solution during fluid pumping enabling a new function. Importantly, the micropump can be fabricated and assembled without needing a cleanroom, making it more accessible. This feature is advantageous for researchers and practitioners, eliminating a significant barrier to entry. By combining commercially available components with 3D printing technology, this micropump presents a cost-effective and versatile solution for on-chip applications in biomedical research and analysis.

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