Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review

Liao, Zerong; Zhang, Yang; Li, Yongrui; Miao, Yunfei; Gao, Shimeng; Lin, Fuchang; Deng, Yulin; Li, Geng

doi:10.1016/j.bios.2018.11.032

Cited by 162 publications

(78 citation statements)

References 103 publications

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“…It allows for parallel detection of multiple analytes, thus largely increasing the sample throughput and improving the sensing efficiency. [31,32] Lab-on-a-chip (LOC) devices and microfluidic systems thus have become useful solutions to the abovementioned challenges. They aim to manipulate liquids at micro-or even nanoliter scale, which largely decrease the sample volume and reduce the reagent cost.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Whispering Gallery Mode Optical Sensors for Biological Applications

Wang

Zeng

Humbert

et al. 2020

Laser & Photonics Reviews

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Whispering gallery mode (WGM) resonators have been exploited as a highly sensitive and efficient sensing technique in the past few years. They offer the advantages of ultrahigh sensitivity, compact size, and label-free sensing capability. More recently, with the rapid development of microfluidic technologies, many integrated WGM sensors, by combining the portability of lab-on-chip devices and the high sensitivity of WGM resonators, have emerged. The capabilities of efficient sample handling and multiplexed analyte detection offered by these systems have led to many biological and chemical sensing applications, especially for the detection of single particle or biomolecule. In this review, different sensing mechanisms based on integrated whispering gallery mode resonators are introduced. Various geometries of WGM cavities including solid, liquid, and hollow resonators and a detailed discussion on their integration with microfluidic devices are also covered. Different types of packaging schemes and integration methods are compared in terms of ease of fabrication and device performance. Finally, recent applications of microfluidic-based WGM sensors for detecting biological and chemical target molecules are discussed, with a prospect on future challenges and trends of development in microfluidics for multiplexed detection.

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Section: Introductionmentioning

confidence: 99%

Microfluidic Whispering Gallery Mode Optical Sensors for Biological Applications

Wang

Zeng

Humbert

et al. 2020

Laser & Photonics Reviews

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“…The demand for label-free, low-cost, highly-sensitive and compact optical sensors keeps increasing rapidly in many areas, such as biological, environmental and chemical detections [1][2][3][4][5][6][7][8][9][10]. Integrated optical waveguide sensors have been developed as one of the best candidates to satisfy this demand [11,12].…”

Section: Introductionmentioning

confidence: 99%

Design Rule of Mach-Zehnder Interferometer Sensors for Ultra-High Sensitivity

Xie

Zhang

Dai

2020

Sensors

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A design rule for a Mach-Zehnder interferometer (MZI) sensor is presented, allowing tunable sensitivity by appropriately choosing the MZI arm lengths according to the formula given in this paper. The present MZI sensor designed by this method can achieve an ultra-high sensitivity, which is much higher than any other traditional MZI sensors. An example is given with silicon-on-insulator (SOI) nanowires and the device sensitivity is as high as 106 nm/refractive-index -unit (or even higher), by choosing the MZI arms appropriately. This makes it possible for one to realize a low-cost optical sensing system with a detection limit as high as 10−6 refractive-index-unit, even when a cheap optical spectrum analyzer with low-resolution (e.g., 1 nm) is used for the wavelength-shift measurement.

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“…Currently, these problems are tackled by enlarging the chip size or by using sophisticated microfluidics [6] or packaging techniques [7]. This dramatically increases costs and prohibits ease of use for the surface functionalization [8].…”

Section: Introductionmentioning

confidence: 99%

CMOS-Compatible Silicon Photonic Sensor for Refractive Index Sensing Using Local Back-Side Release

Steglich

Bondarenko

Mai

et al. 2020

IEEE Photon. Technol. Lett.

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Silicon photonic sensors are promising candidates for lab-on-a-chip solutions with versatile applications and scalable production prospects using complementary metal-oxide semiconductor (CMOS) fabrication methods. However, the widespread use has been hindered because the sensing area adjoins optical and electrical components making packaging and sensor handling challenging. In this work, a local backside release of the photonic sensor is employed, enabling a separation of the sensing area from the rest of the chip. This approach allows preserving the compatibility of photonic integrated circuits in the front-end of line and metal interconnects in the back-end of line. The sensor is based on a micro-ring resonator and is fabricated on wafer-level using a CMOS technology. We revealed a ring resonator sensitivity for homogeneous sensing of 106 nm/RIU.

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Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review

Cited by 162 publications

References 103 publications

Microfluidic Whispering Gallery Mode Optical Sensors for Biological Applications

Microfluidic Whispering Gallery Mode Optical Sensors for Biological Applications

Design Rule of Mach-Zehnder Interferometer Sensors for Ultra-High Sensitivity

CMOS-Compatible Silicon Photonic Sensor for Refractive Index Sensing Using Local Back-Side Release

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