Microfluidic Brain-on-a-Chip: Perspectives for Mimicking Neural System Disorders

Jahromi, Mirza Ali Mofazzal; Abdoli, Amir; Rahmanian, Mohammad; Bardania, Hassan; Bayandori, Mehrdad; Basri, Seyed Masoud Moosavi; Kalbasi, Alireza; Aref, Amir Reza; Karimi, Mahdi; Hamblin, Michael R.

doi:10.1007/s12035-019-01653-2

Cited by 91 publications

(55 citation statements)

References 162 publications

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“…LOC sensing devices are not only used for drug toxicity, metabolic rate, and oxidative stress studies but also for studying brain physiology and relevant disorders by constructing brain-on-a-chip model systems [129]. Norepinephrine is a hormone and neurotransmitter involved in many biological processes in the central and peripheral nervous systems and is targeted to gain new insights about pathophysiological conditions of these systems [130].…”

Section: Electrochemical Methods For Extracellular Metabolitesmentioning

confidence: 99%

Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research

Dervisevic

Tuck

Voelcker

et al. 2019

Sensors

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Lab-on-a-chip sensing technologies have changed how cell biology research is conducted. This review summarises the progress in the lab-on-a-chip devices implemented for the detection of cellular metabolites. The review is divided into two subsections according to the methods used for the metabolite detection. Each section includes a table which summarises the relevant literature and also elaborates the advantages of, and the challenges faced with that particular method. The review continues with a section discussing the achievements attained due to using lab-on-a-chip devices within the specific context. Finally, a concluding section summarises what is to be resolved and discusses the future perspectives.

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Section: Electrochemical Methods For Extracellular Metabolitesmentioning

confidence: 99%

Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research

Dervisevic

Tuck

Voelcker

et al. 2019

Sensors

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“…Organs-on-a-chip (OoCs) are microfluidic cell culture devices in which (human) cells are cultured in engineered microenvironments that imitate the essential aspects of multicellular architectures, dynamic, tissue-tissue interfaces, physicochemical microenvironments, flow, and gradients found in the human body [197]. A wide range of tissues and organs have been modeled, including heart [198], kidney [199], brain [200], liver [201], blood vessels [202], lymphoid follicle [203], and intestine [204]. For this review, we discuss the use of OoCs to study intestinal dynamics with a specific focus on the gut microbiome and infectious diseases.…”

Section: Organs-on-a-chip/microphysiological Systemsmentioning

confidence: 99%

Links between Nutrition, Infectious Diseases, and Microbiota: Emerging Technologies and Opportunities for Human-Focused Research

et al. 2020

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The interaction between nutrition and human infectious diseases has always been recognized. With the emergence of molecular tools and post-genomics, high-resolution sequencing technologies, the gut microbiota has been emerging as a key moderator in the complex interplay between nutrients, human body, and infections. Much of the host–microbial and nutrition research is currently based on animals or simplistic in vitro models. Although traditional in vivo and in vitro models have helped to develop mechanistic hypotheses and assess the causality of the host–microbiota interactions, they often fail to faithfully recapitulate the complexity of the human nutrient–microbiome axis in gastrointestinal homeostasis and infections. Over the last decade, remarkable progress in tissue engineering, stem cell biology, microfluidics, sequencing technologies, and computing power has taken place, which has produced a new generation of human-focused, relevant, and predictive tools. These tools, which include patient-derived organoids, organs-on-a-chip, computational analyses, and models, together with multi-omics readouts, represent novel and exciting equipment to advance the research into microbiota, infectious diseases, and nutrition from a human-biology-based perspective. After considering some limitations of the conventional in vivo and in vitro approaches, in this review, we present the main novel available and emerging tools that are suitable for designing human-oriented research.

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“…One of the most promising approaches in recent years is the development of hiPSCs-derived neuronal cultures that can 'self-assemble' within microfluidic devices and therefore promote neurite outgrowth and interaction with other neural cell-types and enhance synaptic connections [61]. These so-called "organs-in-a-chip" are set to revolutionize drug-discovery [62][63][64].…”

Section: Challenges and Perspectivesmentioning

confidence: 99%

Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms

et al. 2020

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Human induced pluripotent stem cells (hiPSCs) have transformed conventional drug discovery pathways in recent years. In particular, recent advances in hiPSC biology, including organoid technologies, have highlighted a new potential for neural drug discovery with clear advantages over the use of primary tissues. This is important considering the financial and social burden of neurological health care worldwide, directly impacting the life expectancy of many populations. Patient-derived iPSCs-neurons are invaluable tools for novel drug-screening and precision medicine approaches directly aimed at reducing the burden imposed by the increasing prevalence of neurological disorders in an aging population. 3-Dimensional self-assembled or so-called ‘organoid’ hiPSCs cultures offer key advantages over traditional 2D ones and may well be gamechangers in the drug-discovery quest for neurological disorders in the coming years.

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Microfluidic Brain-on-a-Chip: Perspectives for Mimicking Neural System Disorders

Cited by 91 publications

References 162 publications

Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research

Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research

Links between Nutrition, Infectious Diseases, and Microbiota: Emerging Technologies and Opportunities for Human-Focused Research

Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms

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