Microfluidic biosensors for microwave dielectric spectroscopy

Leroy, Jonathan; Dalmay, Claire; Landoulsi, Alaeddine; Hjeij, Fatima; Mélin, Carole; Bessette, Barbara; Puch, Christophe Bounaix Morand Du; Giraud, Stéphanie; Lautrette, Christophe; Battu, Serge; Lalloué, Fabrice; Jauberteau, Marie‐Odile; Bessaudou, Annie; Blondy, Pierre; Pothier, A.

doi:10.1016/j.sna.2015.04.002

Cited by 53 publications

(31 citation statements)

References 23 publications

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“…Than brain, liver, and fat were measured in a similar way. Permittivity can be calculated via (1). Often, relative permittivity should be used to express electrical properties of materials, and relative permittivity of tissue is the ratio of permittivity of tissue and the permittivity of vacuum [31]; that is, = / 0 .…”

Section: Resultsmentioning

confidence: 99%

“…Biological effects induced by electromagnetic radiation depend on electric properties of biological tissue during exposure to electromagnetic radiation. Because of difficulties in measurement of biological tissue in vivo and permittivity of biological tissue which shows nonlinear characteristics in frequency domain, determining effective permittivity of biological tissue has received repeated attention in recent years [1][2][3]. Many techniques and principles of testing permittivity in biological tissue are similar to the traditional engineering materials.…”

Section: Introductionmentioning

confidence: 99%

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Effective Permittivity of Biological Tissue: Comparison of Theoretical Model and Experiment

Ning

Zhang

2017

Mathematical Problems in Engineering

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Permittivity of biological tissue is a critical issue for studying the biological effects of electromagnetic fields. Many theories and experiments were performed to measure or explain the permittivity characteristics in biological tissue. In this paper, we investigate the permittivity parameter in biological tissues via theoretical and experimental analysis. Firstly, we analyze the permittivity characteristic in tissue by using theories on composite material. Secondly, typical biological tissues, such as blood, fat, liver, and brain, are measured by HP4275A Multi-Frequency LCR Meter within 10 kHz to 10 MHz. Thirdly, experimental results are compared with the Bottcher-Bordewijk model, the Skipetrov equation, and the Maxwell-Gannett theory. From the theoretical perspective, blood and fat are regarded as the composition of liver and brain because of the high permittivity in blood and the opposite in fat. Volume fraction of blood in liver and brain is analyzed theoretically, and the applicability and the limitation of the models are also discussed. These results benefit further study on local biological effects of electromagnetic fields.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effective Permittivity of Biological Tissue: Comparison of Theoretical Model and Experiment

Ning

Zhang

2017

Mathematical Problems in Engineering

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“…Also, microwave structures can be readily implemented in the integrated circuits, which have become a favourable platform due to their constantly decreasing cost. As such, microwave sensors have found numerous applications including permittivity sensing [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], strain and displacement sensing [ 16 , 17 , 18 , 19 , 20 ], detection of biomolecules [ 21 ], glucose monitoring [ 22 , 23 ], dielectric spectroscopy for food quality control [ 24 , 25 ], gas sensing [ 26 , 27 , 28 ], and concentration measurements of liquid solutions [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

A Microwave Microfluidic Sensor Based on a Dual-Mode Resonator for Dual-Sensing Applications

Janković

Radonić

2017

Sensors

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In this paper, we propose a novel microwave microfluidic sensor with dual-sensing capability. The sensor is based on a dual-mode resonator that consists of a folded microstrip line loaded with interdigital lines and a stub at the plane of symmetry. Due to the specific configuration, the resonator exhibits two entirely independent resonant modes, which allows simultaneous sensing of two fluids using a resonance shift method. The sensor is designed in a multilayer configuration with the proposed resonator and two separated microfluidic channels—one intertwined with the interdigital lines and the other positioned below the stub. The circuit has been fabricated using low-temperature co-fired ceramics technology and its performance was verified through the measurement of its responses for different fluids in the microfluidic channels. The results confirm the dual-sensing capability with zero mutual influence as well as good overall performance. Besides an excellent potential for dual-sensing applications, the proposed sensor is a good candidate for application in mixing fluids and cell counting.

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“…Currently the development of sensitive and label-free biosensors, able to handle biological cells for individual and accurate analysis, attracts many research efforts especially in the microwave community [1][2][3][4][5]. Labeling procedures are generally expensive, time-consuming and potentially cytotoxic, whereas label-free detection can preserve cell viability and enable post-analysis cell utilization.…”

Section: Introductionmentioning

confidence: 99%

Biological cell discrimination based on their high frequency dielectropheretic signatures at UHF frequencies

Hjeij

Dalmay

Bessette

et al. 2017

2017 IEEE MTT-S International Microwave Symposium (IMS)

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This paper reports on the application of dielectrophoresis techniques in the radiofrequency range, in order to probe inner dielectric specificities and therefore characterize individual biological cells. The novelty of this work consists in exploring the capability of UHF signals to generate DEP-driven motion effects on flowing biological cells in a microfluidic micro-device. Additionally, with applied signals above 50MHz, distinct cross-over frequencies can be identified as function of both the cell type and the difference in the intracellular dielectric features, and between intracellular and extracellular media. Several experimental campaigns were led on three distinct cell lines by thoroughly scanning the UHF spectrum and specifically measuring the resulting second cross-over frequency for each cell type. The experimental results suggest that significant cross-over frequency differences can be observed from one cell line to the other and confirm that their high frequency DEP characteristics can be a relevant cell signature for discriminating them. This work is a first step towards the development of a UHF-DEP cytometer.

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Microfluidic biosensors for microwave dielectric spectroscopy

Cited by 53 publications

References 23 publications

Effective Permittivity of Biological Tissue: Comparison of Theoretical Model and Experiment

Effective Permittivity of Biological Tissue: Comparison of Theoretical Model and Experiment

A Microwave Microfluidic Sensor Based on a Dual-Mode Resonator for Dual-Sensing Applications

Biological cell discrimination based on their high frequency dielectropheretic signatures at UHF frequencies

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