Microfluidic biosensing of circulating tumor cells (CTCs): Recent progress and challenges in efficient diagnosis of cancer

Farshchi, Fatemeh; Hasanzadeh, Mohammad

doi:10.1016/j.biopha.2020.111153

Cited by 52 publications

(36 citation statements)

References 92 publications

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“…Cancer metastasis is a disease in which tissue cells grow uncontrollably and escape from the position of the primary tumor to invade other distant tissues or organs via the circulatory system of the body (see Figure 1 ), a process that substantially boosts the morbidity and lethality of cancer in patients. Cancer can easily go unnoticed at early stages because of a lack of clinical symptoms and because histopathological examination is not useful in detecting the primary extension of tumor cells in general [ 8 ]. Tumor cells become circulating tumor cells (CTCs) when they intrusively enter the circulation system that causes cancer metastasis.…”

Section: Systematic Descriptionmentioning

confidence: 99%

“…Cancer metastasis triggers systematic pathological changes that need whole-body treatment, including surgical operation and chemotherapy due to lesions in multiple secondary organs. Diverse tumors metastasize specifically to particular secondary organs or tissues due to distinctive signals that stimulate the interaction between cell types and respond to the mechanical properties of microenvironments or the chemokines of secondary tumor sites [ 2 , 8 , 9 ]. In the process of metastasis, the early diagnosis and prognosis of cancer patients largely depends on the isolation and analysis of CTCs.…”

Section: Systematic Descriptionmentioning

confidence: 99%

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Machine Learning-Driven Multiobjective Optimization: An Opportunity of Microfluidic Platforms Applied in Cancer Research

Liu

2022

Cells

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Cancer metastasis is one of the primary reasons for cancer-related fatalities. Despite the achievements of cancer research with microfluidic platforms, understanding the interplay of multiple factors when it comes to cancer cells is still a great challenge. Crosstalk and causality of different factors in pathogenesis are two important areas in need of further research. With the assistance of machine learning, microfluidic platforms can reach a higher level of detection and classification of cancer metastasis. This article reviews the development history of microfluidics used for cancer research and summarizes how the utilization of machine learning benefits cancer studies, particularly in biomarker detection, wherein causality analysis is useful. To optimize microfluidic platforms, researchers are encouraged to use causality analysis when detecting biomarkers, analyzing tumor microenvironments, choosing materials, and designing structures.

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Section: Systematic Descriptionmentioning

confidence: 99%

Section: Systematic Descriptionmentioning

confidence: 99%

Machine Learning-Driven Multiobjective Optimization: An Opportunity of Microfluidic Platforms Applied in Cancer Research

Liu

2022

Cells

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“…For instance, Khademhossieni's group and Zhou's group reviewed the progress in electrochemical detection of breast cancer cells and other CTCs [55,56]. Farshchi et al reviewed recent progress and challenges in microfluidic biosensing of CTCs [57]. Koo et al summarized the applications of magnetic nanomaterials in electrochemical detection of diverse circulating cancer biomarkers [58].…”

Section: Introductionmentioning

confidence: 99%

Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells

2021

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The accurate analysis of circulating tumor cells (CTCs) holds great promise in early diagnosis and prognosis of cancers. However, the extremely low abundance of CTCs in peripheral blood samples limits the practical utility of the traditional methods for CTCs detection. Thus, novel and powerful strategies have been proposed for sensitive detection of CTCs. In particular, nanomaterials with exceptional physical and chemical properties have been used to fabricate cytosensors for amplifying the signal and enhancing the sensitivity. In this review, we summarize the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, including fluorescence, colorimetry, surface-enhanced Raman scattering, chemiluminescence, electrochemistry, electrochemiluminescence, photoelectrochemistry and so on.

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“…Microfluidic biosensors are a new type of bioassays that have attracted special attention due to their great features such as, good sensitivity, easy transportation and using a small number of samples. 4,5 One of the most common cancers among men is prostate cancer, which is known as the sixth deadliest cancer. 5 The cancer-specific antigen is called PSA, which is one of the best markers for detecting prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

An Innovative Immunoanalysis Strategy towards Sensitive Recognition of PSA Biomarker in Human Plasma Samples Using Flexible and Portable Paper Based Biosensor: A New Platform towards POC Detection of Cancer Biomarkers Using Integration of Pen-on Paper Technology with Immunoassays Methods

et al. 2021

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Background: The prostate-specific antigen (PSA) is one of the best markers for detecting prostate cancer. Rapid and real time recognition of PSA biomarker could be helpful in the early diagnosis and efficient treatment of prostate cancer. One of the usual methods to identify this biomarker is ELISA, which has a picomolar detection range but requires specialized personnel and also this technique is time-consuming and expensive. Methods: Cost-effective POC devices are great solutions because they are very cost-effective, sensitive and simple, do not require expert operators and have a high response time in a short time. With that in mind, in this work, a novel and simple label-free paper-based electrochemical immunosensor were designed by using conductive Ag-ink and designed directly by pen on paper technique on the surface of photographic paper, which is a suitable substrate for antibody immobilization, for rapid detection of PSA. Results: Based on the obtained results, under the optimum conditions, the synthesized Ag ink has a great substrate for antibody (Ab) and antigen (Ag) immobilization. The linear range was from 0.001 to 30 μg/L and the obtained low limite of quantification (LLOQ) was 0.001μg/L. This immunosensor also tested in human plasma samples, which had good analytical power. Conclusion: The proposed paper-based immunoassay could be a hopefully new and cheap tool for the diagnosis of other biomarkers.

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Microfluidic biosensing of circulating tumor cells (CTCs): Recent progress and challenges in efficient diagnosis of cancer

Cited by 52 publications

References 92 publications

Machine Learning-Driven Multiobjective Optimization: An Opportunity of Microfluidic Platforms Applied in Cancer Research

Machine Learning-Driven Multiobjective Optimization: An Opportunity of Microfluidic Platforms Applied in Cancer Research

Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells

An Innovative Immunoanalysis Strategy towards Sensitive Recognition of PSA Biomarker in Human Plasma Samples Using Flexible and Portable Paper Based Biosensor: A New Platform towards POC Detection of Cancer Biomarkers Using Integration of Pen-on Paper Technology with Immunoassays Methods

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