Microfluidic‐based nanoparticle synthesis and their potential applications

Abstract

Microfluidic-based nanoparticle synthesis and their potential applicationsA lot of substantial innovation in advancement of microfluidic field in recent years to produce nanoparticle reveals a number of distinctive characteristics, for instance, compactness, controllability, fineness in process, and stability along with minimal reaction amount. Recently, a prompt development, as well as realization in the production of nanoparticles in microfluidic environment having dimension of micro to nanometers and constituents extending from metals, semiconductors to polymers, has been made. Microfluidics technology integrates fluid mechanics for the production of nanoparticles having exclusive with homogenous sizes, shapes, and morphology, which are utilized in several bioapplications such as biosciences, drug delivery, and healthcare including food engineering. Nanoparticles are usually well-known for having fine and rough morphology because of their small dimensions including exceptional physical, biological, chemical, and optical properties. Though the orthodox procedures need huge instruments, costly autoclaves, use extra power, extraordinary heat loss, as well as take surplus time for synthesis. Additionally, this is fascinating to systematize, assimilate, in addition, to reduce traditional tools onto one platform to produce micro and nanoparticles. The synthesis of nanoparticles by microfluidics permits fast handling besides better efficacy of method utilizing the smallest components for process. Herein, we will focus on synthesis of nanoparticles by means of microfluidic devices intended for different bioapplications.

Pulsatile Controlled Release and Stability Evaluation of Polymeric Particles Containing Piper nigrum Essential Oil and Preservatives

“…Controlled release of bioactive compounds is the basic principle of encapsulated systems [ 7 ]. Considerable efforts have been devoted to the development of environmentally friendly particles for encapsulation of essential oils [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], which have been widely applied as alternative controlling agents for agricultural pests [ 16 , 17 , 18 ] and for pharmacological purposes [ 19 , 20 ]. Specifically, the effectiveness of Piper nigrum (black pepper) essential oil against insects, mites, larvae, and aphids has been widely reported [ 21 , 22 ], as well as for the treatment of various diseases, such as intermittent fever, dysentery, stomachache, worms, and piles [ 23 ].…”

Alternative Controlling Agent of Theobroma grandiflorum Pests: Nanoscale Surface and Fractal Analysis of Gelatin/PCL Loaded Particles Containing Lippia origanoides Essential Oil

“…The increasing interest in biodegradable particles has accelerated their development process for new technological applications [ 1 , 2 , 3 , 4 , 5 ], particularly in environmentally friendly polymeric particles containing encapsulated essential oils [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ].…”

Facile production of quercetin nanoparticles using 3D printed centrifugal flow reactors

“…Additionally, most microuidic devices require expensive syringe or pressure-controlled pumps for their operation, which hinders translation and widespread adoption of these techniques. 31 Furthermore, channel clogging caused by the accumulation of precipitated nanoparticles remains an issue, 32,36,42 and uid leakages can occur at connections between the microuidic device and pump units as a result of this clogging or inefficient sealing. Despite the challenges involved, recent studies have highlighted the research progress made to develop microuidic devices that can sustain greater ow rates (including patented designs).…”

“…One approach is microuidic solvent-antisolvent precipitation. 30,31 In this method supersaturation is achieved by the addition of an antisolvent (usually water) to an organic solution of the API, which causes nucleation and precipitation of drug particles. 25,32 The precipitation process comprises three stages, as postulated by the LaMer mechanism.…”

“…Numerous systems exploiting this technology have been developed in recent years. 31,[35][36][37][38][39] Considering differences between these systems, microuidic devices for nanoprecipitation share common advantages over batch methods. The conned space of microchannels allows the manipulation of small liquid volumes, which reduces the mixing path of solvent and antisolvent.…”