Microfluidic assembly of uniform fluorescent microbeads from quantum‐dot‐loaded fluorine‐containing microemulsion

Chen, Jie; Zhu, Liangliang; Xie, He-Yi; Zhang, Jing; Mao, Yongsheng; Huang, Zhenhong; Shi, Bo; Chen, Su

doi:10.1002/pi.4737

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…These dried supracolloidal fibers could be transferred to light-weight highly porous nanocomposite materials. In addition, fluorescent quantum dot (QD)-loaded microbeads were fabricated in microfluidic devices by Chen et al [57], based on functional fluorine-containing microemulsions with copolymers as the core and glycidyl methacrylate (GMA) as the shell.…”

Section: Multi-emulsion Of Microdropletsmentioning

confidence: 99%

A review on self-assembly in microfluidic devices

Dou

Wang

Jin

et al. 2017

J. Micromech. Microeng.

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Self-assembly is a process that operates over a vast range of length and time scales. Microfluidic technology has been proven to be a powerful tool to manipulate micro- and nano-scale substrates with precise control over size and speed using various fluidic materials and properties. In this review, we discuss the current status of microfluidic technology in manipulating fluid dynamics and interfacial phenomena which influence self-assembly process and resulted structures. The self-assembled materials/structures were summarized and discussed as the sequence of the objective size at the micro-, nano- and molecular scale. Overall, microfluidics is becoming a useful tool to manipulate various fluids regarding to physical and chemical properties, being inherently suitable for self-assembly process control.

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Section: Multi-emulsion Of Microdropletsmentioning

confidence: 99%

A review on self-assembly in microfluidic devices

Dou

Wang

Jin

et al. 2017

J. Micromech. Microeng.

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“…The methodology has been implemented for more high-capacity and monodisperse particle production using a flow-focusing nozzle to form chloroform droplets of QDs and poly(styrene-co-maleic anhydride) dispersed in a reactor volume filled with an aqueous phase (concentration-controlled flow focusing, CCFF). ,, In an adaption of the CCFF technique, the QD/poly(styrene-co-maleic anhydride) polymer/solvent mixture is emulsified into an aqueous phase by passing the mixture through a (Shirasu) porous glass membrane (SPG-CCFF) to form monodisperse droplets with a smaller lower bound (∼1 μm) for the microbead size range than can be achieved through CCFF. Flow focusing and solvent extraction in microfluidic geometries has also been used to form either poly(lactide- co -glycolide)/QD or polycaprolactone/QD , QD/polymer composites or composites of nanoparticles coated with QDs …”

Section: Introductionmentioning

confidence: 99%

“…Flow focusing and solvent extraction in microfluidic geometries has also been used to form either poly(lactide-co-glycolide)/QD 103 or polycaprolactone/ QD 104,105 QD/polymer composites or composites of nanoparticles coated with QDs. 106 From the above review, preparation methods in which the QDs are embedded within polymer microbeads during bead formation (solvent extraction and copolymerization) have the most advantages, as predefined labels can easily be incorporated, the QDs extend throughout the microbead interior, allowing a more easily read label, and these methods combine both barcoding and microbead formation in one step. However, the studies using these methods have also shown that the incorporation of the QDs into the polymer matrix can result in aggregation of the QDs in the polymer microbead composite.…”

Section: ■ Introductionmentioning

confidence: 99%

Reduction in Aggregation and Energy Transfer of Quantum Dots Incorporated in Polystyrene Beads by Kinetic Entrapment due to Cross-Linking during Polymerization

2015

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We report the development of barcoded polystyrene microbeads, approximately 50 μm in diameter, which are encoded by incorporating multicolored semiconductor fluorescent nanocrystals (quantum dots or QDs) within the microbeads and using the emission spectrum of the embedded QDs as a spectral label. The polymer/nanocrystal bead composites are formed by polymerizing emulsified liquid droplets of styrene monomer and QDs suspended in an immiscible continuous phase (suspension polymerization). We focus specifically on the effect of divinylbenzene (DVB) added to cross-link the linearly growing styrene polymer chains and the effect of this cross-linking on the state of aggregation of the nanocrystals in the composite. Aggregated states of multicolor QDs give rise to nonradiative resonance energy transfer (RET) which distorts the emission label from a spectrum recorded in a reference solvent in which the nanocrystals are well dispersed and unaggregated. A simple barcode is chosen of a mixture of QDs emitting at 560 (yellow) and 620 nm (red). We find that for linear chain growth (no DVB), the QDs aggregate as is evident from the emission spectrum and the QD distribution as seen from confocal laser scanning microscopy (CLSM) and transmission electron microscopy (TEM) images. Increasing the extent of cross-linking by the addition of DVB is shown to significantly decrease the aggregation and provide a clear label. We suggest that in the absence of cross-linking, linearly growing polymer chains, through enthalpic and entropic effects, drive the nanocrystals into inclusions, while cross-linking kinetically entraps the particle and prevents their aggregation.

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Smart Delivery Systems Based on Poly(glycidyl methacrylate)s‐Coated Organic/Inorganic Core–Shell Nanohybrids

Tan

2019

Macromol. Rapid Commun.

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Smart delivery systems have gained momentum over the last few decades due to their potential to realize enhanced therapeutic efficacy. Poly(glycidyl methacrylate)s (PGMAs), which spring up like mushrooms, have drawn great attention in the theranostics field, especially in multifunctional theranostic systems. The marriage of PGMAs with functional inorganic cores is expected to integrate diagnosis (e.g., fluorescence, X‐ray computed tomography, magnetic resonance, photoacoustic and upconversion luminescence imaging), treatment, or multimodal synergistic therapies (e.g., chemotherapy, gene therapy, photothermal therapy) in one pot for personalized medicine. In this review, recent progress in various PGMA‐coated nanohybrids based on the type of integrated inorganic nanoparticle, including silica nanoparticles, magnetic nanoparticles, quantum dots, gold nanoparticles, gold nanorods, metal‐organic frameworks, cellulose nanocrystals, and their core‐shell nanostructures is systematically reviewed. Future work in this field is anticipated to be devoted to developing efficient real‐time‐imaging‐guided multimodal synergistic therapies.

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Microfluidic assembly of uniform fluorescent microbeads from quantum‐dot‐loaded fluorine‐containing microemulsion

Cited by 3 publications

References 36 publications

A review on self-assembly in microfluidic devices

A review on self-assembly in microfluidic devices

Reduction in Aggregation and Energy Transfer of Quantum Dots Incorporated in Polystyrene Beads by Kinetic Entrapment due to Cross-Linking during Polymerization

Smart Delivery Systems Based on Poly(glycidyl methacrylate)s‐Coated Organic/Inorganic Core–Shell Nanohybrids

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